Compression pressure-induced synergy in xanthan and locust bean gum hydrogels. Effect in drug delivery

Article Biochemistry & Molecular Biology

Beneficial Effect of Polysaccharide Gel Made of Xanthan Gum and Locust Bean Gum on Bovine Oocytes

Shunsuke Hara et al.

Summary: The study focused on the impact of polysaccharides gels made of xanthan gum and locust bean gum on oocyte maturation and identified the molecules responsible for the positive effects of the gel culture system. The gel culture system significantly improved the development of embryos, with matured oocytes showing higher lipid content and identified molecular pathways. The presence of estradiol and TGFB1 in the gel culture system played a key role in enhancing oocyte quality and embryonic development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Pharmacology & Pharmacy

The Role of Crosslinker Content of Positively Charged NIPAM Nanogels on the In Vivo Toxicity in Zebrafish

Roberta Bilardo et al.

Summary: Polymeric nanogels have advantages as drug delivery systems, but limited data is available on their biocompatibility. Researchers found that the chemical structure, crosslinking degree, and surface charge of nanogels can influence their toxicity. Therefore, it is important to consider these factors when designing nanogels for drug delivery.

PHARMACEUTICS (2023)

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Review Biochemistry & Molecular Biology

Insights on Chemical Crosslinking Strategies for Proteins

Brindha Jayachandran et al.

Summary: Protein crosslinking is essential for the fabrication of biomaterials, and the chemical method is widely used, involving the formation of bonds between proteins and chemical compounds. This review discusses various protein crosslinking strategies, reactions, properties, and applications.

MOLECULES (2022)

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Article Toxicology

In vitro toxicity assessment of crosslinking agents used in hyaluronic acid dermal filler

Chang Hee Jeong et al.

Summary: The study found that BDDE led to higher cytotoxicity, affected cell viability and membrane integrity, increased ROS levels and MMP loss, and elevated inflammatory responses in cells, whereas PEGDE showed lower cytotoxicity, ROS production, and inflammatory responses. The data suggests that PEGDE is safer than BDDE as a crosslinker in HA dermal fillers.

TOXICOLOGY IN VITRO (2021)

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Article Pharmacology & Pharmacy