Tazarotene-calcipotriol loaded Nanostructured lipid carrier enriched hydrogel: A novel dual drug synergistic approach towards Psoriasis management

Article Pharmacology & Pharmacy

Novel Synergistic Approach: Tazarotene-Calcipotriol-Loaded-PVA/PVP-Nanofibers Incorporated in Hydrogel Film for Management and Treatment of Psoriasis

Sunita Thakur et al.

Molecular Pharmaceutics (2023)

Article Engineering, Biomedical

Biomimicking dual drug eluting twisted electrospun nanofiber yarns for post-operative wound healing

Pragya Singh et al.

Summary: The developed electrospun nanofiber yarns loaded with vancomycin and ferulic acid show excellent antimicrobial activity and wound healing potential, making them suitable for surgical wound healing applications.

BIOMEDICAL MATERIALS (2023)

Add to Collection

Article Pharmacology & Pharmacy

Multilayered nanofibrous scaffold of Polyvinyl alcohol/gelatin/poly (lactic-co-glycolic acid) enriched with hemostatic/antibacterial agents for rapid acute hemostatic wound healing

Giriraj Pandey et al.

Summary: This study aims to develop a nanofibrous wound dressing for topical drug delivery in wound healing applications. The electrospinning technique is used to fabricate bioabsorbable nanofiber scaffolds enriched with thrombin and vancomycin. The nanofibrous scaffolds demonstrate excellent biocompatibility, antimicrobial activity, and wound healing capability in both in vitro and in vivo studies. Based on the results, it can be concluded that the nanofibrous scaffolds loaded with thrombin and vancomycin have promising potential as a dressing material for hemostatic wound healing applications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Add to Collection

Article Pharmacology & Pharmacy

Formulation of Miconazole-Loaded Chitosan-Carbopol Vesicular Gel: Optimization to In Vitro Characterization, Irritation, and Antifungal Assessment

Syed Sarim Imam et al.

Summary: The present study aimed to develop MZBSo bilosomes and MZBSo gel. MZBSo presented nano-sized vesicles with high entrapment efficiency and suitable ζ potential, while MZBSoG2 showed good pH, viscosity, spreadability, and a slower drug release. MZBSoG2 was non-irritant and exhibited significant antifungal activity. Stability study results showed no significant changes. MZ-loaded gels could improve therapeutic efficacy.

PHARMACEUTICS (2023)

Add to Collection

Article Pharmacology & Pharmacy

c(RGDfK) anchored surface manipulated liposome for tumor-targeted tyrosine kinase inhibitor (TKI) delivery to potentiate liver anticancer activity

Payal Deepak et al.

Summary: Current anticancer drug research focuses on tumor-targeted administration as the best strategy to improve efficacy and reduce toxicity. Nanocarrier-mediated targeted drug delivery systems have emerged as an innovative technique for hepatocellular carcinoma (HCC) treatment, overcoming limitations of traditional chemotherapy. In this study, av beta 3 integrin receptor targeted c(RGDfK) surface modified liposomes were developed to enhance the selectivity and therapeutic efficacy of Gefitinib (Gefi) for HCC cells. The modified liposomes showed higher cytotoxicity, better cellular uptake, and improved in vivo biodistribution compared to conventional liposomes and free Gefi. These findings suggest that the c(RGDfK)-surface modified liposomes can serve as an efficient carrier for targeted delivery of anticancer drugs.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Add to Collection

Review Dermatology

Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice

Gabriella Fabbrocini et al.

Summary: Most patients with psoriasis have mild-to-moderate disease and can be treated with topical therapy as first-line treatment. A fixed-dose combination of betamethasone dipropionate and vitamin D analogue foam has been approved as the first-line topical treatment for psoriasis in the USA and EU. This position paper provides a critical discussion on the long-term management of psoriasis with this foam, including its biological rationale, evidence, and application in different disease severities and treatment regimens.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Transcutaneous delivery of mung bean-derived nanoparticles for amelioration of psoriasis-like skin inflammation

Haifeng Sun et al.

Summary: This study reports the modulation of the skin immune system using mung bean-derived nanoparticles for the amelioration of psoriasis-like skin inflammation. These nanoparticles exhibit high antioxidant activity and can reduce reactive oxygen species and modulate the immune microenvironment. Topical administration of these nanoparticles can achieve the homeostasis of polarized macrophages and antagonize the activation of inflammatory signaling pathways, resulting in the alleviation of skin inflammation.

NANOSCALE (2022)

Add to Collection

Article Dermatology

Efficacy of combined fractional carbon dioxide laser and topical tazarotene in nail psoriasis treatment: A randomized intrapatient left-to-right study

Nagwa Essa Abd Elazim et al.

Summary: The study showed that combined fractional CO2 laser with topical tazarotene was more effective in treating nail psoriasis compared to tazarotene monotherapy, especially in improving nail bed lesions. Both treatments significantly improved the severity of nail lesions, with the combined therapy showing greater efficacy for nail bed signs and faster improvement of nail matrix signs. Patient global assessment scores were significantly higher after the combined therapy, and both treatments were well tolerated.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Multifunctional Biomimetic Nanofibrous Scaffold Loaded with Asiaticoside for Rapid Diabetic Wound Healing

Sneha Anand et al.

Summary: This study successfully prepared a multifunctional nanofibrous scaffold loaded with asiaticoside and evaluated its wound healing efficacy in diabetic rats. The nanofibers exhibited good fiber morphology and tensile strength, sustained release of asiaticoside, low cytotoxicity, and excellent antimicrobial activity against common bacteria. In-vivo experiments showed that the nanofibrous scaffold had a better wound healing effect and restored the normal skin structure. These findings suggest that the developed nanofibrous scaffold has great potential for diabetic wound healing applications.

PHARMACEUTICS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Gemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery

Sankha Bhattacharya et al.

Summary: This study focused on the delivery of gemcitabine (GTB) using cationic polymeric nanoparticles for the treatment of ovarian cancer. The cationic formulation, CS-PSar-NPs, showed strong biocompatibility and anticancer activity. By attaching epidermal growth factor receptor variation III (EGFRvIII), the polymeric nanoparticles exhibited improved targeting, cellular penetration, and cytotoxicity. The results suggest that EGFRvIII-conjugated cationic GTB polymeric nanoparticles have the potential to effectively infiltrate ovarian cancer cells.

DRUG DELIVERY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Dual Nanostructured Lipid Carriers/Hydrogel System for Delivery of Curcumin for Topical Skin Applications

Rosa Calderon-Jacinto et al.

Summary: This study focuses on the development and evaluation of a dual nanostructured lipid carrier (NLC)/Carbopol(R)-based hydrogel system for the topical delivery of curcumin to the skin. The results demonstrate that CUR-NLCs have high curcumin antioxidant activity and moderate anti-migration/proliferation effect. The dual CUR-NLC/hydrogel system shows potential application in adjuvant treatment for topical dermatological applications.

BIOMOLECULES (2022)

Add to Collection

Article Chemistry, Medicinal

Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats

Sneha Anand et al.

Summary: This study prepared and evaluated silk-sericin based hybrid nanofibrous mats for the treatment of diabetic foot ulcers. The results showed that these nanofibrous mats exhibited good mechanical properties, sustained drug release, and low cytotoxicity. In addition, they demonstrated excellent wound-healing efficiency in diabetic rats.

PHARMACEUTICALS (2022)

Add to Collection

Article Nanoscience & Nanotechnology

ECM Mimicking Biodegradable Nanofibrous Scaffold Enriched with Curcumin/ZnO to Accelerate Diabetic Wound Healing via Multifunctional Bioactivity

Sachin Yadav et al.

Summary: Foot ulceration is a severe complication of diabetes leading to lower-extremity amputation. The developed chitosan-polyvinyl alcohol blended electrospun nanofiber loaded with bioactive materials demonstrated efficient diabetic wound healing through sustained release of bioactive molecules, anti-bacterial properties, and acceleration of cell migration and proliferation.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Curcumin-based nanotechnology approaches and therapeutics in restoration of autoimmune diseases

Niloufar Rahiman et al.

Summary: Autoimmune diseases occur when the immune system mistakenly attacks normal tissues, leading to inflammation. Curcumin, a natural anti-inflammatory agent, can regulate inflammatory cytokines in immune cells to inhibit autoimmune processes. Encapsulating curcumin in nanocarriers can enhance its beneficial effects.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: Full factorial design optimization, in vitro characterization, and pharmacokinetic evaluation

Ameeduzzafar Zafar et al.

Summary: The objective of this research was to develop, optimize, and evaluate rotigotine-loaded chitosan coated nanostructured lipid carriers for nose-to-brain delivery. The optimized formulation showed small particle size, high encapsulation efficiency, sustained drug release, and improved brain targeting potential. The results suggest that this formulation could be a promising strategy for targeting rotigotine to the brain via intranasal administration.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Article Pharmacology & Pharmacy

Synthesis and appraisal of dalbergin-loaded PLGA nanoparticles modified with galactose against hepatocellular carcinoma: In-vitro, pharmacokinetic, and in-silico studies

Anurag Kumar Gautam et al.

Summary: This study synthesized a synthetic version of DL and developed DL nanoparticles, demonstrating their high therapeutic effectiveness against HCC. In vivo pharmacokinetics and bio-distribution experiments revealed that DL nanoparticles outperformed pristine DL in terms of pharmacokinetic performance and targeted delivery. In vitro experiments also confirmed the strong apoptotic properties of DL against HCC.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Polymer Science

Preparation of NLCs-Based Topical Erythromycin Gel: In Vitro Characterization and Antibacterial Assessment

Ameeduzzafar Zafar et al.

Summary: In this study, erythromycin-loaded nanostructured lipid carriers (NLCs) were prepared and transformed into an in-situ gel system for the treatment of bacterial conjunctivitis. The optimized formulation showed improved drug release, permeation, and antimicrobial activity compared to conventional erythromycin gel, while also demonstrating good biocompatibility in corneal studies.

GELS (2022)

Add to Collection

Article Polymer Science

Development of Apremilast Nanoemulsion-Loaded Chitosan Gels: In Vitro Evaluations and Anti-Inflammatory and Wound Healing Studies on a Rat Model

Mohammed Muqtader Ahmed et al.

Summary: This study developed APL-loaded nanoemulsions using eucalyptus oil, Tween-80, and transcutol-HP as the oil, surfactant, and co-surfactant, respectively. The optimized nanoemulsion was incorporated into chitosan gel and exhibited significant anti-inflammatory and wound healing activity based on in vitro and in vivo studies.

GELS (2022)

Add to Collection

Article Pharmacology & Pharmacy

BBD-Based Development of Itraconazole Loaded Nanostructured Lipid Carrier for Topical Delivery: In Vitro Evaluation and Antimicrobial Assessment

Ameeduzzafar et al.

Summary: The study successfully developed itraconazole-loaded nanostructured lipid carriers and further formulated them into a gel, showing good consistency and spreadability. The nanostructured lipid carrier gel exhibited higher drug release and inhibition effect against fungal infections compared to the control group.

JOURNAL OF PHARMACEUTICAL INNOVATION (2021)

Add to Collection

Article Instruments & Instrumentation

Anacardic acid encapsulated solid lipid nanoparticles forStaphylococcus aureusbiofilm therapy: chitosan and DNase coating improves antimicrobial activity

Md Meraj Anjum et al.

Summary: Biofilm mediated bacterial infections are key in infectious disease progression due to antimicrobial resistance evolution. Traditional antibiotics are inadequate due to increased resistance. Anacardic acid loaded solid lipid nanoparticles offer a promising alternative with enhanced efficacy against biofilm-mediated antimicrobial resistance.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Add to Collection

Article Pharmacology & Pharmacy

Design and characterization of Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels containing Passiflora edulis seeds oil

Karolline Krambeck et al.

Summary: This study successfully designed and characterized Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels with Passiflora edulis seeds oil. The developed NLC showed good stability and particle properties, with superior tyrosinase inhibitory activity and skin retention effects.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Development and In Vitro/In Vivo Evaluation of pH-Sensitive Polymeric Nanoparticles Loaded Hydrogel for the Management of Psoriasis

Muhammad Imran Asad et al.

Summary: The study developed a nanoparticle-loaded chitosan hydrogel with Methotrexate (MTX) for treating psoriasis in a mouse model, demonstrating its potential effectiveness in the treatment of psoriasis.

NANOMATERIALS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Curcumin loaded polycaprolactone-/polyvinyl alcohol-silk fibroin based electrospun nanofibrous mat for rapid healing of diabetic wound: An in-vitro and in-vivo studies

Yashi Agarwal et al.

Summary: Electrospinning is a versatile technique for nanofibers fabrication, which is crucial for rapid healing of diabetic wounds. The combination of silk fibroin-curcumin based nanofibers with PCL and PVA strengthens the wound healing properties. The loaded nanofibers demonstrate sustained release of curcumin and show great potential for diabetic wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Add to Collection

Article Pharmacology & Pharmacy

Nanostructured Lipid Carrier-Mediated Transdermal Delivery of Aceclofenac Hydrogel Present an Effective Therapeutic Approach for Inflammatory Diseases

Neeraj K. Garg et al.

Summary: In this study, an NLC-based hydrogel formulation of ACE was developed and characterized, showing high stability and superior skin delivery efficiency. Compared with conventional marketed gel formulations, the NLC-based gel formulation of ACE may offer promising advantages as a nanoscale lipid carrier for topical applications.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Review Dermatology

Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits

Mark G. Lebwohl et al.

Summary: Psoriasis is a lifelong disease with cycles of remission and relapse. Topical treatments are the primary therapy for most patients, with novel fixed-dose combinations offering improved safety and efficacy. The new formulations utilize multiple mechanisms of action to deliver active ingredients more efficiently at lower doses.

DERMATOLOGY AND THERAPY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Topical Delivery of Apremilast Loaded Nanostructured Lipid Carrier Based Hydrogel for Psoriasis Therapy

S. M. Sindhoor et al.

Summary: The study successfully formulated and characterized Apremilast loaded nanostructured lipid carriers, which demonstrated significant advantages in treating psoriasis, including enhanced permeation, improved skin retention, and extended-release capabilities.

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL (2021)

Add to Collection

Review Chemistry, Analytical

Review on Characteristics and Analytical Methods of Tazarotene: An Update

Juilee Gaikwad et al.

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Instruments & Instrumentation

Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis

Juliana Santos Rosa Viegas et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

Add to Collection

Review Medicine, General & Internal

Pathophysiology, Clinical Presentation, and Treatment of Psoriasis A Review

April W. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Engineering, Biomedical

Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice

Sudeep Sudesh Pukale et al.

ACTA BIOMATERIALIA (2020)

Add to Collection

Article Dermatology

Vitamin D receptor gene polymorphisms are associated with psoriasis susceptibility and the clinical response to calcipotriol in psoriatic patients

Junlin Liu et al.

EXPERIMENTAL DERMATOLOGY (2020)

Add to Collection

Article Chemistry, Medicinal

Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model

Priyadarshini Sathe et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Psoriasis Pathogenesis and Treatment

Adriana Rendon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Pharmacology & Pharmacy

Alginate lyase immobilized chitosan nanoparticles of ciprofloxacin for the improved antimicrobial activity against the biofilm associated mucoid P. aeruginosa infection in cystic fibrosis

Krishna Kumar Patel et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Add to Collection

Article Dermatology

Rapid onset of action of calcipotriol/betamethasone dipropionate cutaneous foam in psoriasis, even in patients with more severe disease

A. E. Pink et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Effect of penetration enhancers and amorphization on transdermal permeation flux of raloxifene-encapsulated solid lipid nanoparticles: an ex vivo study on human skin

Krishna Kumar Patel et al.

APPLIED NANOSCIENCE (2019)

Add to Collection

Article Chemistry, Medicinal

An Ex Vivo Evaluation of Moxifloxacin Nanostructured Lipid Carrier Enriched In Situ Gel for Transcorneal Permeation on Goat Cornea

Shilpkala Gade et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Add to Collection

Article Chemistry, Physical

Nanostructured lipid carriers incorporated in alginate hydrogel: Enhanced stability and modified behavior in gastrointestinal tract

Rui Sun et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Risk Factors for the Development of Psoriasis

Koji Kamiya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Medicine, Research & Experimental

Antibiofilm Potential of Silver Sulfadiazine-Loaded Nanoparticle Formulations: A Study on the Effect of DNase-I on Microbial Biofilm and Wound Healing Activity

Krishna Kumar Patel et al.

MOLECULAR PHARMACEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Alpha-linolenic acid based nano-suspension protect against lipopolysaccharides induced mastitis by inhibiting NFκBp65, HIF-1α, and mitochondria-mediated apoptotic pathway in albino Wistar rats

Rajnish Kumar Yadav et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

Add to Collection

Article Chemistry, Physical

Development of Anacardic Acid/hydroxypropyl-β-cyclodextrin inclusion complex with enhanced solubility and antimicrobial activity

Md Meraj Anjum et al.

JOURNAL OF MOLECULAR LIQUIDS (2019)

Add to Collection

Article Multidisciplinary Sciences

Preparation of luliconazole nanocrystals loaded hydrogel for improvement of dissolution and antifungal activity

Manish Kumar et al.

HELIYON (2019)

Add to Collection

Review Dermatology

Pathogenesis of psoriasis and development of treatment

Eisaku Ogawa et al.

JOURNAL OF DERMATOLOGY (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Development and optimization of sulforaphane-loaded nanostructured lipid carriers by the Box-Behnken design for improved oral efficacy against cancer: in vitro, ex vivo and in vivo assessments

Kriti Soni et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Carbomer gel bearing methotrexate loaded lipid nanocontainers shows improved topical delivery intended for effective management of psoriasis

Priyanka Tripathi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Add to Collection

Article Pharmacology & Pharmacy

Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study

Rhythm Arora et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

Add to Collection

Article Pharmacology & Pharmacy

A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation

Vivek Avasatthi et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2016)

Add to Collection

Article Nanoscience & Nanotechnology

Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

Paruvathanahalli Siddalingam Rajinikanth et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Cytokines in psoriasis

Jaymie Baliwag et al.

CYTOKINE (2015)

Add to Collection

Article Nanoscience & Nanotechnology

Formulation and delivery of itraconazole to the brain using a nanolipid carrier system

Wei Meng Lim et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

Add to Collection

Article Pharmacology & Pharmacy

Lipid Nanoformulations for Oral Delivery of Bioactives: An Overview

Ranjana Gupta et al.

CURRENT DRUG THERAPY (2014)

Add to Collection

Tazarotene-calcipotriol loaded Nanostructured lipid carrier enriched hydrogel: A novel dual drug synergistic approach towards Psoriasis management

Related references

Export Citation

Share Paper