☆ 4.3 Letter

SARS-CoV-2: an environmental trigger of Darier's disease?

JOURNAL OF DERMATOLOGICAL TREATMENT (2023)

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Darier's Disease Flare following COVID-19 Vaccine

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Summary: Darier's disease is a rare genodermatosis characterized by papules and nail abnormalities, typically not inflammatory in nature but triggered by external factors such as sun exposure, friction, or infection. A case report discusses a flare of Darier's disease following COVID-19 vaccination, considering possible mechanisms linking the two and emphasizing the need for awareness among clinicians due to the close temporal association.

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Role of pro-inflammatory cytokines in the pathophysiology of herpes simplex virus superinfection in Darier's disease

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Summary: Darier's disease (DD) and Hailey-Hailey disease (HHD) are hereditary skin disorders caused by genetic mutations, which are susceptible to eczema herpeticum (EH) induced by HSV. Elevated pro-inflammatory cytokines IL-6 and TNF-alpha contribute to severe EH lesions by enhancing HSV growth, and IL-6 exacerbates DD and HHD by downregulating responsible genes.

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