Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 5, Pages 881-884Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06762b
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Funding
- National Natural Science Foundation of China [81402785]
- Institute of Materia Medica, Chinese Academy of Medical Sciences [2014RC01]
- National Science and Technology Major Project [2009ZX09301002-001]
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Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, M-W similar to 205.19, lambda(ab) similar to 350 nm, lambda(em) similar to 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues.
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