4.6 Article

Major Adverse Cardiovascular Events by Baseline Cardiovascular Risk in Patients with Ulcerative Colitis Treated with Tofacitinib: Data from the OCTAVE Clinical Programme

Related references

Note: Only part of the references are listed.
Article Rheumatology

Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance

Christina Charles-Schoeman et al.

Summary: This post hoc analysis observed a higher risk of MACE associated with tofacitinib compared to TNFi in RA patients with a history of ASCVD. Among patients without a history of ASCVD but with prevalent CV risk factors, there does not appear to be a difference in MACE risk between tofacitinib 5 mg twice daily and TNFi, although any absolute risk excess is likely low.

ANNALS OF THE RHEUMATIC DISEASES (2023)

Article Gastroenterology & Hepatology

Tofacitinib for the Treatment of Ulcerative Colitis: An Integrated Summary of up to 7.8 Years of Safety Data from the Global Clinical Programme

William J. Sandborn et al.

Summary: This study provides a summary of tofacitinib safety in the treatment of ulcerative colitis. The results showed a low incidence of adverse events, with stable rates in patients treated for at least 7.8 years. The incidence rates of important safety events were generally below 2.0, except for herpes zoster.

JOURNAL OF CROHNS & COLITIS (2023)

Article Gastroenterology & Hepatology

Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open-label, long-term extension study with up to 7.0 years of treatment

William J. Sandborn et al.

Summary: Tofacitinib demonstrated consistent safety over up to 7.0 years, with data up to Month 36 supporting long-term efficacy in the treatment of ulcerative colitis patients.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

Article Medicine, General & Internal

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis

Steven R. Ytterberg et al.

Summary: In this trial comparing the use of tofacitinib with a TNF inhibitor in a cardiovascular risk-enriched population, the risks of major adverse cardiovascular events (MACE) and cancers were found to be higher with tofacitinib, and it did not meet noninferiority criteria. Several adverse events were more common with tofacitinib.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Gastroenterology & Hepatology

Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial

Severine Vermeire et al.

Summary: The study presented the primary completion analysis of tofacitinib treatment for ulcerative colitis. Most patients in stable remission on 10 mg BID maintenance therapy maintained remission following dose reduction, especially those in deep endoscopic remission and without prior TNFi failure. Longer follow-up is needed to fully understand the impact of dose reduction on maintenance of remission. Safety findings were consistent with the established safety profile of tofacitinib.

JOURNAL OF CROHNS & COLITIS (2021)

Article Medicine, General & Internal

Moderate and High Disease Activity Predicts the Development of Carotid Plaque in Rheumatoid Arthritis Patients without Classic Cardiovascular Risk Factors: Six Years Follow-Up Study

Ivan Ferraz-Amaro et al.

Summary: Patients with rheumatoid arthritis have a higher risk of subclinical atherosclerosis and cardiovascular disease, with those experiencing higher baseline disease activity showing an increased likelihood of developing carotid plaque.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Gastroenterology & Hepatology

Thromboembolic and atherosclerotic cardiovascular events in inflammatory bowel disease: epidemiology, pathogenesis and clinical management

Jasmijn A. M. Sleutjes et al.

Summary: Inflammatory bowel disease is associated with an increased risk of cardiovascular disease, particularly venous thromboembolism, atherosclerotic cardiovascular disease, and heart failure. Chronic systemic inflammation is the main cause of this increased risk, leading to a hypercoagulable state and accelerating atherosclerosis. More research is needed to accurately define the effects of IBD on cardiovascular risk.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

Article Rheumatology

Disease activity influences the reclassification of rheumatoid arthritis into very high cardiovascular risk

Ivan Ferraz-Amaro et al.

Summary: Reclassification into very high CV risk after carotid ultrasound assessment occurs in more than half of patients with RA. This reclassification can be independently explained by the activity of the disease.

ARTHRITIS RESEARCH & THERAPY (2021)

Article Gastroenterology & Hepatology

Tofacitinib Treatment Is Associated With Modest and Reversible Increases in Serum Lipids in Patients With Ulcerative Colitis

Bruce E. Sands et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease JACC Review Topic of the Week

Miguel Cainzos-Achirica et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary

Donna K. Arnett et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Gastroenterology & Hepatology

Safety of Tofacitinib for Treatment of Ulcerative Colitis, Based on 4.4 Years of Data From Global Clinical Trials

William J. Sandborn et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

Article Medicine, General & Internal

Cardiovascular disease in immune-mediated inflammatory diseases: A cross-sectional analysis of 6 cohorts

Benjamin Fernandez-Gutierrez et al.

MEDICINE (2017)

Article Medicine, General & Internal

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Inflammatory Bowel Disease Is Associated With an Increased Risk of Hospitalization for Heart Failure A Danish Nationwide Cohort Study

Soren Lund Kristensen et al.

CIRCULATION-HEART FAILURE (2014)

Review Gastroenterology & Hepatology

Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Siddharth Singh et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)

Article Rheumatology

Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies

Juan Antonio Avina-Zubieta et al.

ANNALS OF THE RHEUMATIC DISEASES (2012)

Article Medicine, General & Internal

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Gastroenterology & Hepatology

Epidemiology and Natural History of Inflammatory Bowel Diseases

Jacques Cosnes et al.

GASTROENTEROLOGY (2011)