4.8 Article

Long-acting injectable multipurpose prevention technology for prevention of HIV and unplanned pregnancy

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Isabella C. Young et al.

Summary: The authors developed an injectable, biodegradable, and removable in-situ forming implant (ISFI) that can release cabotegravir (CAB) for more than 6 months, protecting against HIV for an extended period. The implant was well-tolerated and provided complete protection against multiple rectal SHIV challenges in female macaques. This study supports the clinical use of CAB ISFIs for ultra-long-acting HIV pre-exposure prophylaxis (PrEP) in humans.

NATURE COMMUNICATIONS (2023)

Article Engineering, Biomedical

Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy

Isabella C. Young et al.

Summary: The article introduces a 3D printed multipurpose prevention technology (MPT) intravaginal ring (IVR) which can be used for HIV prevention and contraception. The MPT IVR offers a sustained release of drugs for up to 150 days in vitro and 14 days in sheep. It has been found to be safe and well tolerated in macaques, making it a potential option for young women and girls.

BIOMATERIALS (2023)

Article Medicine, Research & Experimental

Long-acting lenacapavir acts as an effective preexposure prophylaxis in a rectal SHIV challenge macaque model

Elena Bekerman et al.

Summary: This study evaluated the efficacy of the long-acting antiretroviral agent Lenacapavir (LEN) for HIV prevention. The results showed that LEN effectively prevented SHIV infection in a macaque model and did not lead to the emergence of drug resistance. These findings support further clinical evaluation of LEN as a HIV PrEP medication in humans.

JOURNAL OF CLINICAL INVESTIGATION (2023)

Article Pharmacology & Pharmacy

Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics

Jordan B. Joiner et al.

Summary: This study investigated the effects of formulation parameters on the in situ forming implant (ISFI) drug delivery system using ultrasound imaging and pharmacokinetics (PK) in mice. The results showed that drug loading extended the degradation time of ISFIs, and there was no statistical difference in drug exposure with different administration routes and injection numbers.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Effects of Drug Physicochemical Properties on In-Situ Forming Implant Polymer Degradation and Drug Release Kinetics

Jordan B. Joiner et al.

Summary: This study characterized the in vitro drug release from in-situ forming implants (ISFIs) for 12 different small molecule drugs. The results demonstrated that drug logP and physical state in the polymer-solvent system are the most important factors in predicting the drug release rate.

PHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

Population pharmacokinetics of cabotegravir following administration of oral tablet and long-acting intramuscular injection in adult HIV-1-infected and uninfected subjects

Kelong Han et al.

Summary: A population pharmacokinetic model of cabotegravir was developed using data from phase 1, 2, and 3 studies. The model provides valuable information for dosing strategies and future study design. The study found that race and age were not significant covariates, while factors such as gender, injection method, and body mass index had an impact on pharmacokinetics.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2022)

Article Chemistry, Multidisciplinary

Long-acting biodegradable implant for sustained delivery of antiretrovirals (ARVs) and hormones

Linying Li et al.

Summary: This study developed a long-acting implant system that provides sustained delivery of contraceptive and antiretroviral drugs, offering a solution to reproductive health challenges faced by women worldwide.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Polymer Science

Multipurpose Prevention Technologies: Oral, Parenteral, and Vaginal Dosage Forms for Prevention of HIV/STIs and Unplanned Pregnancy

Isabella C. Young et al.

Summary: There is a high global prevalence of HIV, sexually transmitted infections (STIs), and unplanned pregnancies. Current preventative daily oral dosing regimens can be ineffective due to low patient adherence. Multipurpose prevention technologies (MPTs) in conjunction with sustained release delivery systems can reduce these high rates, providing users with efficacious, acceptable, and easily accessible technology.

POLYMERS (2021)

Article Public, Environmental & Occupational Health

The Promise of the Dual Prevention Pill: A Framework for Development and Introduction

Barbara A. Friedland et al.

Summary: Women of reproductive age need more options for HIV and pregnancy prevention, and a daily oral pill combining oral contraceptives and PrEP could be the fastest route to getting an MPT product into their hands. This dual prevention pill has the potential to increase PrEP uptake by leveraging the existing oral contraceptive market and targeting women currently using condoms or with an unmet need for contraception. Successful rollout of the DPP will require careful consideration of user-, provider-, and product-centered factors to ensure maximum product acceptability and effective use.

FRONTIERS IN REPRODUCTIVE HEALTH (2021)

Review Pharmacology & Pharmacy

Vaginal multipurpose prevention technologies: promising approaches for enhancing women's sexual and reproductive health

Trinette Fernandes et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

Article Multidisciplinary Sciences

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

S. Rahima Benhabbour et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Martina Kovarova et al.

NATURE COMMUNICATIONS (2018)

Review Pharmacology & Pharmacy

An update on multipurpose prevention technologies for the prevention of HIV transmission and pregnancy

David R. Friend

EXPERT OPINION ON DRUG DELIVERY (2016)

Article Chemistry, Multidisciplinary

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

Chieh-Cheng Huang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Article Chemistry, Multidisciplinary

Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment

Antoinette G. Nelson et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Multidisciplinary

N-methyl pyrrolidone/bone morphogenetic protein-2 double delivery with in situ forming implants

Lindsay S. Karfeld-Sulzer et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Medicinal

The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

Luis Solorio et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Review Biochemistry & Molecular Biology

Multipurpose prevention technologies: the future of HIV and STI protection

Josa A. Fernandez-Romero et al.

TRENDS IN MICROBIOLOGY (2015)

Review Immunology

Formulation and pharmacology of long-acting cabotegravir

Christine Trezza et al.

CURRENT OPINION IN HIV AND AIDS (2015)

Article Pharmacology & Pharmacy

Dissolution Studies of Poorly Soluble Drug Nanosuspensions in Non-sink Conditions

Peng Liu et al.

AAPS PHARMSCITECH (2013)

Article Microbiology

Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model

John A. Moss et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetic, Pharmacodynamic and Drug-Interaction Profile of the Integrase Inhibitor Dolutegravir

Mackenzie L. Cottrell et al.

CLINICAL PHARMACOKINETICS (2013)

Review Pharmacology & Pharmacy

Injectable implants for the sustained release of protein and peptide drugs

Priyanka Agarwal et al.

DRUG DISCOVERY TODAY (2013)

Review Chemistry, Multidisciplinary

PLGA in situ implants formed by phase inversion: Critical physicochemical parameters to modulate drug release

Marianne Parent et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Review Obstetrics & Gynecology

Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies

Andrea Ries Thurman et al.

INTERNATIONAL JOURNAL OF WOMENS HEALTH (2013)

Article Pharmacology & Pharmacy

In situ forming implant for controlled delivery of an anti-HIV fusion inhibitor

Deepak N. Kapoor et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

Review Chemistry, Multidisciplinary

In situ forming implants - an attractive formulation principle for parenteral depot formulations

Sabine Kempe et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Instruments & Instrumentation

Effect of cargo properties on in situ forming implant behavior determined by noninvasive ultrasound imaging

Luis Solorio et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2012)

Article Engineering, Biomedical

Characterization of formulation parameters affecting low molecular weight drug release from in situ forming drug delivery systems

Ravi B. Patel et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2010)