Journal
JOURNAL OF CONTROLLED RELEASE
Volume 362, Issue -, Pages 210-224Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2023.08.039
Keywords
Ischemic stroke; Mesenchymal stem cells; Cellular backpacks; Luteolin; Inflammation
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This study utilized a novel drug delivery system to enhance the therapeutic effects of mesenchymal stem cells (MSCs) in ischemic stroke by tethering ROS-responsive luteolin-loaded micelles to the surface of the MSCs.
Mesenchymal stem cells (MSCs) exhibited remarkable therapeutic potential in ischemic stroke due to their exceptional immunomodulatory ability and paracrine effect; they have also been regarded as excellent neuroprotectant delivery vehicles with inflammatory tropism. However, the presence of high levels of reactive oxygen species (ROS) and an oxidative stress environment at the lesion site inhibits cell survival and further therapeutic effects. Using bioorthogonal click chemistry, ROS-responsive luteolin-loaded micelles were tethered to the surface of MSCs. As MSCs migrated to the ischemic brain, the micelles would achieve ROS-responsive release of luteolin to protect MSCs from excessive oxidative damage while inhibiting neuroinflammation and scavenging ROS to ameliorate ischemic stroke. This study provided an effective and prospective therapeutic strategy for ischemic stroke and a framework for a stem cell-based therapeutic system to treat inflammatory cerebral diseases.
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