Journal
JOURNAL OF CONTROLLED RELEASE
Volume 362, Issue -, Pages 548-564Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2023.09.014
Keywords
Colorectal cancer; Nanoscale drug delivery systems; Immunotherapy; Gut microbiota; Therapy resistance
Ask authors/readers for more resources
This review provides a cutting-edge summary of nanomedicine-based treatment in colorectal cancer, including drug delivery systems, therapeutic strategies, and efforts to address therapy resistance, metastasis, and recurrence. The potential of gut microbiota regulation in preventing and treating colorectal cancer is also discussed.
Colorectal cancer (CRC), one of the most common and deadliest diseases worldwide, poses a great health threat and social burden. The clinical treatments of CRC encompassing surgery, chemotherapy, and radiotherapy are challenged with toxicity, therapy resistance, and recurrence. In the past two decades, targeted therapy and immunotherapy have greatly improved the therapeutic benefits of CRC patients but they still suffer from drug resistance and low response rates. Very recently, gut microbiota regulation has exhibited a great potential in preventing and treating CRC, as well as in modulating the efficacy and toxicity of chemotherapy and immunotherapy. In this review, we provide a cutting-edge summary of nanomedicine-based treatment in colorectal cancer, highlighting the recent progress of oral and systemic tumor-targeting and/or tumor-activatable drug delivery systems as well as novel therapeutic strategies against CRC, including nano-sensitizing immunotherapy, anti-inflammation, gut microbiota modulation therapy, etc. Finally, the recent endeavors to address therapy resistance, metastasis, and recurrence in CRC were discussed. We hope this review could offer insight into the design and development of nanomedicines for CRC and beyond.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available