Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 73, Pages 13953-13956Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04791a
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Funding
- National Science Foundation of China [21202093, 21472112]
- Program for New Century Excellent Talents in University [NCET-13-0346]
- Shandong Science Fund for Distinguished Young Scholars [JQ201404]
- Young Scientist Foundation Grant of Shandong Province [BS2013YY001]
- Fundamental Research Funds of Shandong University [2014JC005, 2015JC035]
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An oxidative cross-dehydrogenative coupling (CDC) of isoquinolines with methyl arenes has been developed, allowing for the facile synthesis of a broad range of structurally diverse C-1-benzyl and -benzoyl isoquinolines. The direct use of readily available methyl arenes as coupling partners avoids unproductive steps for preactivating the functional group installation, and is therefore attractive. The method exhibits excellent chemoselectivity, affording exclusive benzylated products in the presence of DTBP and a catalytic amount of Y(OTf)(3), and yielding benzoylated ones with TBHP and a catalytic amount of MnO2.
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