Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 53, Pages 10612-10615Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01979f
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Funding
- NSF of China [21125209, 21332003, 21402051]
- MOST of China [2011CB808600]
- STCSM [12JC1403800]
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A highly efficient sequencing of catalytic asymmetric three-component reactions of alcohols, diazo compounds and aldimines/aldehydes with one-pot subsequent cyclization reactions was reported. The development of a robust and versatile Rh(II)/Zr(IV)-BINOL co-catalytic system not only gives high diastereo- and enantioselective controls of the three-component reaction, but also shows excellent functionality tolerances that allow a wide range of functionalities to be pre-installed in each component and readily undergo one-pot subsequent cyclization reactions, thus providing rapid and diversity-oriented synthesis (DOS) of different types of chiral nitrogen- and/or oxygen-containing polyfunctional heterocycles.
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