A clinical comparative analysis between expanded NIHSS and original NIHSS in posterior circulation ischemic stroke

Background: The NIHSS is used routinely but has drawbacks. One of them is its inefficiency in detecting all signs of posterior circulation strokes. Since its declaration as a possible substitute for NIHSS in posterior circulation strokes in 2016; the expanded NIHSS (e-NIHSS) has not been paid much attention.The current study assesses clinically the value of e-NIHSS over NIHSS in posterior circulation strokes as regards the percentage of cases with different/higher scores, the significance of such scoring on management decisions, the weight of baseline e-NIHSS as a prognostic tool on 90 days functional outcome and its cut off value. Methods: The current longitudinal observational study was conducted on 79 cases after formal written consent who presented with posterior circulation strokes and confirmed by brain imaging. Results: In Comparison to NIHSS; the e-NIHSS score was higher in 36 cases at baseline and in 30 cases on discharge.The e-NIHSS median was two points higher at baseline and 24 h and was one point higher on discharge P < 0.001. A baseline moderate/moderate-severe was more common with e-NIHSS (n 50, 63.3%). In terms of 90 days outcome; a less favorable outcome (>2) was evident in cases with different scoring (e-NIHSS > NIHSS) indicating more sensitivity of e-NIHSS in prognosing 90 days outcome. ROC curve showed 82% sensi-tivity and 81% specificity with a significant area under the curve (=0.858) on scoring & GE; 8 in e-NIHSS.Conclusion: e-NIHSS is diagnostically and prognostically relevant tool in posterior circulation strokes and ought to be considered in future guidelines.

Automated summary

This study assesses the clinical value of e-NIHSS in posterior circulation strokes and finds that e-NIHSS has higher scores than NIHSS at baseline and on discharge. It is more sensitive in predicting 90-day functional outcome and shows high sensitivity and specificity. The study concludes that e-NIHSS is a valuable tool for diagnosis and prognosis in posterior circulation strokes.