Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 99, Pages 17536-17539Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc07853a
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Funding
- National Basic Research Program of China (973 Program) [2012CB932502, 2015CB932100]
- National Science Foundation of China [U1332210, 21171156, 21573213]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
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Self-assembled cholesterol-asplatin-incorporated nanoparticles (SCANs) were prepared for oral delivery of a Pt(IV) prodrug. SCANs exhibit high gastrointestinal stability, sustained drug release and enhanced cell uptake. The oral bioavailability of SCANs was 4.32-fold higher than that of free Pt(IV) prodrugs. The oral administration of SCANs efficaciously inhibits tumor growth with negligible toxicity.
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