Dexmedetomidine for cancer surgery: A short-term infusion with long-term benefits. Or just another smoking mirror?

Article Anesthesiology

Dexmedetomidine provides type-specific tumour suppression without tumour-enhancing effects in syngeneic murine models

Wanpei Chen et al.

Summary: Dexmedetomidine, a commonly used anaesthetic adjuvant, does not affect the growth or metastasis of most tumors, but it inhibits the growth of colorectal cancer by modulating tumor CD4+ and CD8+ T cells.

BRITISH JOURNAL OF ANAESTHESIA (2023)

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Article Medicine, General & Internal

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

Ronan J. Kelly et al.

Summary: In patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, adjuvant therapy with nivolumab significantly improved disease-free survival compared to placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Anesthesiology

Epidural Anesthesia-Analgesia and Recurrencefree Survival after Lung Cancer Surgery: A Randomized Trial

Zhen-Zhen Xu et al.

Summary: The study found that combining epidural anesthesia with general anesthesia did not improve recurrence-free, overall, or cancer-specific survival after lung cancer surgery compared to general anesthesia alone. The results showed similar outcomes between the two groups, with no significant differences in survival rates. Additionally, patients receiving combined epidural-general anesthesia had a higher incidence of intraoperative hypotension.

ANESTHESIOLOGY (2021)

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Article Surgery