4.7 Article

Photo, pH, and thermo triple-responsive spiropyran-based copolymer nanoparticles for controlled release

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 63, Pages 12633-12636

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04087f

Keywords

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Funding

  1. National Natural Science Foundation of China [51373025, 21074010, 51425201]
  2. Program for New Century Excellent Talents in University [NCET-11-0582]

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A spiropyran-based amphiphilic random copolymer was synthesized and self-assembled into photo-, pH-, and thermo-responsive micellar nanoparticles. The triple-stimuli triggered morphological changes of the nanoparticles were revealed by TEM and DLS. Highly efficient controlled release of encapsulated molecules, coumarin 102, from the nanoparticles under stimulation of UV light, acid and the combined stimuli could be realized.

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