☆ 4.7 Article

Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration

JOURNAL OF CELL BIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Review Pathology

Desmosomal Cadherins in Health and Disease

Marihan Hegazy et al.

Summary: Desmosomal cadherins are a recently evolved adhesive substance that forms the core of desmosomes, which are crucial for tissue integrity. They not only resist mechanical stress, but also promote tissue differentiation and morphogenesis. Interfering with desmosomal cadherin function can lead to various diseases. Our understanding of their regulation and function is still limited, but new directions for combating desmosome-related diseases are emerging.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Bidirectional regulation of desmosome hyperadhesion by keratin isotypes and desmosomal components

Fanny Buchau et al.

Summary: Desmosomes are intercellular junctions that mediate cohesion and communication in tissues exposed to mechanical strain. The expression of K17 prevents the formation of stable, hyperadhesive desmosomes, while overexpression of Dsg3 or DPII enhances the formation of hyperadhesive desmosomes.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Add to Collection

Article Medicine, Research & Experimental

Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

Lisa M. Godsel et al.

Summary: Research reveals that genetic deficiency of Dsg1 causes a psoriatic-like inflammatory signature, and treatment with targeted therapy significantly improves skin lesions in patients.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection

Review Oncology

Mechanisms of immune activation and regulation: lessons from melanoma

Shelly Kalaora et al.

Summary: Melanoma, a highly immunogenic skin cancer, involves complex immune responses. This research is crucial for the development of new cancer therapies.

NATURE REVIEWS CANCER (2022)

Add to Collection

Review Dermatology

Skin pigmentation and its control: From ultraviolet radiation to stem cells

Joseph Michael Yardman-Frank et al.

Summary: This review provides an overview of skin pigmentation mechanisms, including melanocytes, tanning pathways, vitiligo, follicular pigmentation, and hair greying. It highlights the importance of future research and potential intervention points in these areas.

EXPERIMENTAL DERMATOLOGY (2021)

Add to Collection

Review Cell & Tissue Engineering

Reemergence of neural crest stem cell-like states in melanoma during disease progression and treatment

Johanna Diener et al.

Summary: Melanoma is a deadly skin cancer with high metastatic potential, and advances in targeted therapy and immunotherapy have improved treatment. However, drug resistance remains a major obstacle. The progression of melanoma is associated with cellular dedifferentiation and gene regulatory networks, requiring novel approaches to combat stemness characteristics.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Oncology

Molecular Features of Cancer-associated Fibroblast Subtypes and their Implication on Cancer Pathogenesis, Prognosis, and Immunotherapy Resistance

Phillip M. Galbo et al.

Summary: This study conducted a comprehensive analysis of CAFs from multiple cancer types, identified shared molecular characteristics in CAF subtypes, and revealed the association of different CAF subtypes with clinical outcomes and immunotherapy resistance.

CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Variability within rare cell states enables multiple paths toward drug resistance

Benjamin L. Emert et al.

Summary: Differences in molecular features among individual cells can lead to dramatic differences in cell fate, such as the survival or death of cancer cells upon drug treatment. The Rewind methodology combines genetic barcoding with RNA fluorescence in situ hybridization to capture rare cells that give rise to cellular behaviors of interest. By applying Rewind to BRAF(V600E) melanoma, researchers traced drug-resistant cell fates back to single-cell gene expression differences in their drug-naive precursors, revealing hidden, rare-cell variability that underlies a range of latent phenotypic outcomes upon drug exposure.

NATURE BIOTECHNOLOGY (2021)

Add to Collection

Review Oncology

Rethinking the biology of metastatic melanoma: a holistic approach

Hendrik H. L. D. Vandyck et al.

Summary: Melanoma-related mortality has remained stable due to treatment failure of metastatic disease and limited knowledge on metastasis formation. Melanoma cells manipulate the tumor microenvironment and express various cell adhesion molecules to promote invasion and metastasis. Studies have shown that primary melanomas shed exosomes to create a favorable premetastatic niche in the microenvironment of secondary organs and lymph nodes.

CANCER AND METASTASIS REVIEWS (2021)

Add to Collection

Review Oncology

Participation of keratinocyte- and fibroblast-derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders

Parth R. Upadhyay et al.

Summary: Human epidermal melanocytes play a crucial role in sensing the environment and protecting the skin, with their survival and function being regulated by paracrine factors produced by epidermal keratinocytes and dermal fibroblasts. Disruption of this network can lead to pigmentary disorders.

PIGMENT CELL & MELANOMA RESEARCH (2021)

Add to Collection

Review Biochemistry & Molecular Biology

How Neural Crest Transcription Factors Contribute to Melanoma Heterogeneity, Cellular Plasticity, and Treatment Resistance

Anja Wessely et al.

Summary: Early detection is crucial for the prognosis of cutaneous melanoma, and new therapies have significantly improved patient survival. The aggressiveness of melanoma is closely related to the embryonic origin of melanocytes and melanoma cells, as well as cellular plasticity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Oncology

HOXC10 promotes growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway

Yuanxin Miao et al.

Summary: The study demonstrated that HOXC10 promotes growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway. Inhibition of HOXC10 has therapeutic potential in melanoma by suppressing Slug and YAP/TAZ signaling pathway.

DISCOVER ONCOLOGY (2021)

Add to Collection

Article Oncology

Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling

Christopher R. Arnette et al.

PIGMENT CELL & MELANOMA RESEARCH (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Tracing the Evolutionary Origin of Desmosomes

Kathleen J. Green et al.

CURRENT BIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Single cell transcriptomics of human epidermis identifies basal stem cell transition states

Shuxiong Wang et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Medicine, Research & Experimental

P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer

Dahong Yao et al.

THERANOSTICS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

Yuan Cheng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

Add to Collection

Article Oncology

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

Jennifer Tsoi et al.

CANCER CELL (2018)

Add to Collection

Article Oncology

Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution

A. Hunter Shain et al.

CANCER CELL (2018)

Add to Collection

Article Allergy

Epithelial barrier dysfunction in desmoglein-1 deficiency

Laura Polivka et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Add to Collection

Article Immunology

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma

Melina Mescher et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Add to Collection

Article Multidisciplinary Sciences

Rare cell variability and drug- induced reprogramming as a mode of cancer drug resistance

Sydney M. Shaffer et al.

NATURE (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting Lyn regulates Snail family shuttling and inhibits metastasis

D. Thaper et al.

ONCOGENE (2017)

Add to Collection

Review Cell Biology

Crosstalk in skin: melanocytes, keratinocytes, stem cells, and melanoma

Joshua X. Wang et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

Add to Collection

Article Oncology

Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion

Carole Siret et al.

BRITISH JOURNAL OF CANCER (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF

Tamar Golan et al.

MOLECULAR CELL (2015)

Add to Collection

Article Dermatology

The Desmosomal Protein Desmoglein 1 Aids Recovery of Epidermal Differentiation after Acute UV Light Exposure

Jodi L. Johnson et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Add to Collection

Article Cell & Tissue Engineering

SNAI2 Controls the Undifferentiated State of Human Epidermal Progenitor Cells

Devendra S. Mistry et al.

STEM CELLS (2014)

Add to Collection

Article Medicine, Research & Experimental

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

Robert M. Harmon et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Add to Collection

Article Genetics & Heredity

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

Liat Samuelov et al.

NATURE GENETICS (2013)

Add to Collection

Review Pathology

Melanoma's connections to the tumour microenvironment

Johanna M. Brandner et al.

PATHOLOGY (2013)

Add to Collection

Article Pathology

Slug Expression during Melanoma Progression

Stephanie H. Shirley et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

Add to Collection

Article Gastroenterology & Hepatology

CD133+liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling

Kwan Ho Tang et al.

HEPATOLOGY (2012)

Add to Collection

Review Pharmacology & Pharmacy

Targeting CXCR1/CXCR2 receptor antagonism in malignant melanoma

Bhawna Sharma et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2010)

Add to Collection

Article Oncology

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion

S. Singh et al.

BRITISH JOURNAL OF CANCER (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine- promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoA

Isabel Molina-Ortiz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Add to Collection

Article Cell Biology

Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

Spiro Getsios et al.

JOURNAL OF CELL BIOLOGY (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Perturbed desmosomal cadherin expression in grainy head-like 1-null mice

Tomasz Wilanowski et al.

EMBO JOURNAL (2008)

Add to Collection

Article Oncology

Melanoma and the Tumor Microenvironment

Jessie Villanueva et al.

CURRENT ONCOLOGY REPORTS (2008)

Add to Collection

Review Biochemistry & Molecular Biology

Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses

Rebecca E. Schweppe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Add to Collection

Review Pathology

Prognosticators of melanoma, the melanoma report, and the sentinel lymph node

AN Crowson et al.

MODERN PATHOLOGY (2006)

Add to Collection

Article Cell Biology

Adhesion, migration and communication in melanocytes and melanoma

NK Haass et al.

PIGMENT CELL RESEARCH (2005)

Add to Collection

Article Cell Biology

Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion

S Getsios et al.

DIFFERENTIATION (2004)

Add to Collection

Article Pathology

E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors

MY Hsu et al.

AMERICAN JOURNAL OF PATHOLOGY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.