☆ 4.7 Review

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications

JOURNAL OF CELL BIOLOGY (2023)

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APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells

Jeannie L. Hernandez et al.

CELL CHEMICAL BIOLOGY (2017)

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Letter Oncology

Palmitoylacyltransferase Zdhhc9 inactivation mitigates leukemogenic potential of oncogenic Nras

P. Liu et al.

LEUKEMIA (2016)

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Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)

Sang Joon Won et al.

ACS CHEMICAL BIOLOGY (2016)

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The Substrate Specificity of Sirtuins

Poonam Bheda et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

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Identification of PSD-95 Depalmitoylating Enzymes

Norihiko Yokoi et al.

JOURNAL OF NEUROSCIENCE (2016)

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ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity

Baoen Chen et al.

NATURE CHEMICAL BIOLOGY (2016)

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Protein prenylation: unique fats make their mark on biology

Mei Wang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

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Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1)

Michal Segal-Salto et al.

PLOS ONE (2016)

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Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Cameron L. Noland et al.

STRUCTURE (2016)

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Activation of STING requires palmitoylation at the Golgi

Kojiro Mukai et al.

NATURE COMMUNICATIONS (2016)

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Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

Tiziano Dallavilla et al.

PLOS COMPUTATIONAL BIOLOGY (2016)

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Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

Elsa Perrody et al.

ELIFE (2016)

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Neuronal ceroid lipofuscinoses

Dragos A. Nita et al.

EPILEPTIC DISORDERS (2016)

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How many lives does CLIMP-63 have?

Patrick A. Sandoz et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

Marco Y. Hein et al.

CELL (2015)

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Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases

Kimon Lemonidis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5

G. Stefano Brigidi et al.

NATURE COMMUNICATIONS (2015)

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Article Oncology

Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation

Lakshmi Reddy Bollu et al.

ONCOTARGET (2015)

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The Roles of Post-translational Modifications in the Context of Protein Interaction Networks

Guangyou Duan et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

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ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

David Tse Shen Lin et al.

ELIFE (2015)

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Article Cell Biology

The Differential Palmitoylation States of N-Ras and H-Ras Determine Their Distinct Golgi Subcompartment Localizations

Stephen J. Lynch et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

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Article Biophysics

The Autodepalmitoylating Activity of APT Maintains the Spatial Organization of Palmitoylated Membrane Proteins

Nachiket Vartak et al.

BIOPHYSICAL JOURNAL (2014)

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Chemoproteomics reveals Toll-like receptor fatty acylation

Nicholas M. Chesarino et al.

BMC BIOLOGY (2014)

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A systematic analysis of protein palmitoylation in Caenorhabditis elegans

Matthew J. Edmonds et al.

BMC GENOMICS (2014)

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NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

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IMMUNITY (2014)

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Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation

Jessica Rios-Esteves et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43

Anne Gauthier-Kemper et al.

MOLECULAR BIOLOGY OF THE CELL (2014)

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Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity

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NATURE NEUROSCIENCE (2014)

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The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Randy Johnson et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

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Physicochemical mechanisms of protein regulation by phosphorylation

Hafumi Nishi et al.

FRONTIERS IN GENETICS (2014)

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Palmitoylation of influenza virus proteins

Michael Veit et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2013)

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Editorial Material Biochemistry & Molecular Biology

Covalent lipid modifications of proteins

Marilyn D. Resh

CURRENT BIOLOGY (2013)

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What does S-palmitoylation do to membrane proteins?

Sanja Blaskovic et al.

FEBS JOURNAL (2013)

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Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Palmitoylation on Conserved and Nonconserved Cysteines of Murine IFITM1 Regulates Its Stability and Anti-Influenza A Virus Activity

Jocelyn C. Hach et al.

JOURNAL OF VIROLOGY (2013)

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Palmitoylated calnexin is a key component of the ribosome-translocon complex

Asvin K. K. Lakkaraju et al.

EMBO JOURNAL (2012)

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S-Palmitoylation and Ubiquitination Differentially Regulate Interferon-induced Transmembrane Protein 3 (IFITM3)-mediated Resistance to Influenza Virus

Jacob S. Yount et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

Christian Hedberg et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Post-translational myristoylation: Fat matters in cellular life and death

Dale D. O. Martin et al.

BIOCHIMIE (2011)

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The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

Jonathan Z. Long et al.

CHEMICAL REVIEWS (2011)

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FKBP12 Binds to Acylated H-Ras and Promotes Depalmitoylation

Ian M. Ahearn et al.

MOLECULAR CELL (2011)

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

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MOLECULAR SYSTEMS BIOLOGY (2011)

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Deep proteome and transcriptome mapping of a human cancer cell line

Nagarjuna Nagaraj et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

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The quantitative proteome of a human cell line

Martin Beck et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

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Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy

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NUCLEIC ACIDS RESEARCH (2011)

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Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

George A. Khoury et al.

SCIENTIFIC REPORTS (2011)

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Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts

Ilya Levental et al.

BIOCHEMISTRY (2010)

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Protein palmitoylation in neuronal development and synaptic plasticity

Yuko Fukata et al.

NATURE REVIEWS NEUROSCIENCE (2010)

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Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein

Corrin E. McBride et al.

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Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors

Laurence Abrami et al.

PLOS PATHOGENS (2010)

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Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

Kun Huang et al.

FASEB JOURNAL (2009)

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Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

Jing Yang et al.

CELL (2008)

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Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method

Jun Zhang et al.

MOLECULAR & CELLULAR PROTEOMICS (2008)

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Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

Laurence Abrami et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking

Peter J. McCormick et al.

TRAFFIC (2008)

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Palmitoylation: policing protein stability and traffic

Maurine E. Linder et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Lysosomal metabolism of lipid-modified proteins

Jui-Yun Lu et al.

JOURNAL OF LIPID RESEARCH (2006)

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Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Yusuke Ohno et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2006)

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Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

L Abrami et al.

JOURNAL OF CELL BIOLOGY (2006)

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DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras

JT Swarthout et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Fatty acylation and prenylation of proteins: what's hot in fat

T Magee et al.

CURRENT OPINION IN CELL BIOLOGY (2005)

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Ubiquitin: structures, functions, mechanisms

CM Pickart et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)

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The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2

G Calero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

L Abrami et al.

JOURNAL OF CELL BIOLOGY (2003)

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Direct visualization of Ras proteins in spatially distinct cell surface microdomains

IA Prior et al.

JOURNAL OF CELL BIOLOGY (2003)

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Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein α subunit deacylation in vivo

JA Duncan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

P Burke et al.

MOLECULAR BIOLOGY OF THE CELL (2001)

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Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

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SCIENCE (2000)

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