One metal two tasks: Reentering the catalytic ending PdII-H for the relay-catalytic cycle for dicarbonylation of amines

A new method for making use of the catalytic ending PdII-H for the relay-catalytic cycle for dicarbonylation of amines has been developed in a buffer condition, which shows an excellent compatible ability to allow two incompatible catalytic systems working simultaneously in the same catalytic system. This protocol features excellent regioselectivity and broad substrate scope. Our combined experimental and computational studies indicated that the reaction proceeds through a Pd0/PdII-H relay-catalytic cycle.

Automated summary

A new method has been developed for the dicarbonylation of amines using the catalytic ending PdII-H in a buffer condition, allowing two incompatible catalytic systems to work simultaneously. This protocol shows excellent regioselectivity and broad substrate scope. Combined experimental and computational studies reveal that the reaction proceeds through a Pd0/PdII-H relay-catalytic cycle.