Predictors and possible mechanisms of premature ventricular contraction induced cardiomyopathy

Premature ventricular complexes (PVCs) are encountered frequently in clinical practice. While PVCs may have various causes, a small number of individuals with PVCs develop cardiomyopathy in the absence of other potential etiologies. When correctly identified, patients with PVC-incuded cardiomyopathy can have dramatic improvement of their cardiomyopathy with treatment of their PVCs. In this focused review, we discuss potential predictors of PVC-induced cardiomyopathy, including PVC frequency, PVC characteristics, and modifiable patient risk factors. We also review some proposed mechanisms of PVC-induced cardiomyopathy and conclude with future directions for research and clinical practice.

Automated summary

Premature ventricular complexes (PVCs) are often encountered in clinical practice. While PVCs can have various causes, a small number of patients develop cardiomyopathy without any other potential etiologies. Identifying and treating PVC-induced cardiomyopathy can lead to significant improvement. This review focuses on potential predictors, characteristics, and modifiable risk factors of PVC-induced cardiomyopathy, as well as proposed mechanisms and future directions for research and clinical practice.