Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 26, Pages 5747-5750Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00082c
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Funding
- NIH [1DP2NS082126]
- NINDS [1R01NS087950, 1R21NS078660, 1R01NS081716]
- NIMH [5R00MH085944]
- Pew Foundation
- Alfred P. Sloan Foundation
- Michael J. Fox Foundation
- NARSAD
- Boston University Biomedical Engineering Department
- Boston University Photonic Center
- NATIONAL INSTITUTE OF MENTAL HEALTH [R00MH085944] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS087950, R21NS078660, DP2NS082126, R01NS081716] Funding Source: NIH RePORTER
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Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.
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