4.7 Article

Direct C-H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 97, Pages 17229-17232

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc07767b

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Funding

  1. National Research Foundation of Korea (NRF) grant - Korea Government (MSIP) [2013R1A2A2A01005249, 2014R1A1A2056809]
  2. National Research Foundation of Korea [2014R1A1A2056809, 2013R1A2A2A01005249] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The rhodium(III)-catalyzed direct functionalization of aniline C-H bonds with alpha-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.

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