BTB protein family and human breast cancer: signaling pathways and clinical progress

BackgroundBreast cancer is considered the number one killer of women both in China and abroad, and the leading cause of cancer death. It severely affects female health-related quality of life. Broad-complex, tramtrack, bric a brac (BTB) protein family was first discovered in drosophila as early as in 1993 by Godt D and peers, since then, more family members and their critical biological functions were uncovered. Moreover, researchers around the world have recently demonstrated that numerous signaling pathways connect BTB family members and human breast cancer.PurposeIn this review, we critically discuss these findings regarding the essential mechanisms and functions of the BTB protein family in mediating the organic processes of human breast cancer. Meanwhile, we summarize the signaling pathways the BTB protein family participates in. And we address that BTB proteins regulate the growth, apoptosis, and other behaviors of breast cancer cells. We also point out the future directions for further studies in this field.MethodsThe relevant online literatures have been reviewed for this article.ConclusionThis review could offer an update on novel molecular targets for treating human breast cancer and new insights into BTB protein family research.

Automated summary

Breast cancer is the leading cause of death for women in China and abroad, with a significant impact on their quality of life. The BTB protein family, initially discovered in drosophila, has been found to be involved in several critical biological functions and signaling pathways related to breast cancer. This review provides an update on potential molecular targets for treating breast cancer and offers new insights into the study of the BTB protein family. Rating: 8/10.