4.6 Article

A prognostic nomogram for predicting recurrence-free survival of stage I-III colon cancer based on immune-infiltrating Treg-related genes

Related references

Note: Only part of the references are listed.
Review Biotechnology & Applied Microbiology

Revisiting the role of CD4+T cells in cancer immunotherapy-new insights into old paradigms

Rong En Tay et al.

Summary: Cancer immunotherapy has transformed cancer treatment, with immune checkpoint blockade therapy and adoptive cell therapy becoming standard care for many cancer types. Recent evidence suggests that CD4(+)T cells play a significant role in the anti-tumour immune response, highlighting their potential importance in cancer immunotherapies.

CANCER GENE THERAPY (2021)

Article Surgery

Prognostic factors for T1-2 colorectal cancer after radical resection: Lymph node distribution is a valuable predictor of its survival

Xing Huang et al.

Summary: Gender, lymph node metastasis, and lymphovascular or nerve invasion are independent prognostic factors for patients with T1-2 colorectal cancer after radical resection. The lymph node distribution system has a better predictive value than the TNM system in lymph node-positive T1-2 CRC patients.

ASIAN JOURNAL OF SURGERY (2021)

Article Oncology

Transcriptional regulation of VEGFA expression in T-regulatory cells from breast cancer patients

Kirti Kajal et al.

Summary: The initiation of new blood vessel formation is crucial for tumor growth, with Treg cells secreting high levels of VEGFA to induce angiogenesis. FOXP3 and STAT3 binding to the VEGFA promoter in Treg cells promotes neo-angiogenesis in breast cancer. Targeting Tregs in mice with breast tumor reduces both tumor growth and neo-angiogenesis levels.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Review Immunology

Regulatory T cell targeting in cancer: Emerging strategies in immunotherapy

Sundee Dees et al.

Summary: Treg cells play a crucial role in maintaining immune homeostasis, and targeting them can enhance antitumor immunity, although the efficacy of current Treg therapies in clinical settings is limited due to lack of specificity. Novel approaches, such as T-cell receptor mimic antibodies and near-infrared photoimmunotherapy, aim to address this limitation in the context of cancer.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements

Ahmed Malki et al.

Summary: Colorectal cancer is the second leading cause of cancer-related mortality rates worldwide, with its prevalence still on the rise. Dysregulation of several cellular signaling pathways in CRC leads to malignant phenotypes. Studying signaling pathways helps elucidate the mechanisms of CRC progression and pharmacotherapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Colon Cancer, Version 2.2021

Al B. Benson et al.

Summary: This section of the NCCN Clinical Practice Guidelines in Oncology focuses on systemic therapy options for metastatic colorectal cancer, with important updates including first-line use of checkpoint inhibitors and expanded recommendations for biomarker testing.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2021)

Article Multidisciplinary Sciences

Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Yang Liu et al.

Summary: Nasopharyngeal carcinoma is characterized by a heterogeneous microenvironment, with single cell sequencing revealing different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells. Intensive inter-cell interactions are observed, potentially promoting the formation of an immune-suppressive niche in the TME.

NATURE COMMUNICATIONS (2021)

Article Oncology

Lymph node status and its impact on the prognosis of left-sided and right-sided colon cancer: A SEER population-based study

Yadi Huang et al.

Summary: The lymph node status has a more significant impact on the risk of death in right-sided colon cancer patients. Therefore, tumor site should be considered when evaluating the outcome of patients based on lymph node status.

CANCER MEDICINE (2021)

Editorial Material Immunology

Wnt-β-catenin as an epigenetic switcher in colonic Treg cells

Stefania Cane et al.

Summary: In the colonic environment, sustained Wnt-beta-catenin activation in regulatory T cells leads to epigenetic rewiring towards proinflammatory ROR gamma t(+) T-reg cells, whose expansion correlates with the progression from inflammatory bowel disease (IBD) to colorectal cancer (CRC).

NATURE IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

Jinghui Zhang et al.

Summary: The Hedgehog (HH) signaling pathway is crucial in gastrointestinal carcinogenesis and the tumor microenvironment (TME), affecting tumor growth, immune tolerance, inflammation, and drug resistance. Inflammatory factors and cancer-associated fibroblasts play vital roles in these processes, and inhibiting HH signaling can normalize the TME. Aberrant HH signaling activation promotes cancer stem cell proliferation and gastrointestinal tumor drug resistance.

ACTA PHARMACEUTICA SINICA B (2021)

Article Oncology

A New Oxaliplatin Resistance-Related Gene Signature With Strong Predicting Ability in Colon Cancer Identified by Comprehensive Profiling

Qiu Lin et al.

Summary: This study establishes a signature based on four oxaliplatin resistance-related genes for predicting survival in colon cancer patients. The signature shows high accuracy in prognostic prediction for colon cancer, helping identify cases with poor prognostic outcomes and shedding light on mechanisms of oxaliplatin resistance.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Prognostic significance of CD163+tumor-associated macrophages in colorectal cancer

Tao Xue et al.

Summary: Infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients, with high-level infiltration associated with shorter overall survival and disease-free survival.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2021)

Review Engineering, Biomedical

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

Shreya Thakkar et al.

ACTA BIOMATERIALIA (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Extent of enhancement on multiphase contrast-enhanced CT images is a potential prognostic factor of stage I-III colon cancer

Zhanhuai Wang et al.

EUROPEAN RADIOLOGY (2019)

Review Medicine, Research & Experimental

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

Xiaofei Cheng et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Oncology

Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor Tcell immunity

Elena E. Tchekneva et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Article Medicine, Research & Experimental

A circRNA signature predicts postoperative recurrence in stage II/III colon cancer

Huai-Qiang Ju et al.

EMBO MOLECULAR MEDICINE (2019)

Article Oncology

WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers

Jason J. Luke et al.

CLINICAL CANCER RESEARCH (2019)

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

Review Immunology

Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?

Luca Parisi et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

Article Biochemistry & Molecular Biology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang et al.

NATURE MEDICINE (2018)

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Review Oncology

The immune contexture in cancer prognosis and treatment

Wolf H. Fridman et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Review Oncology

The Notch pathway in colorectal cancer

Kaitlyn E. Vinson et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Review Immunology

Roles of regulatory T cells in cancer immunity

Yoshiko Takeuchi et al.

INTERNATIONAL IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Takuro Saito et al.

NATURE MEDICINE (2016)

Article Oncology

FoxP3+ and IL-17+ cells are correlated with improved prognosis in cervical adenocarcinoma

Simone Punt et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

Article Biochemistry & Molecular Biology

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

Michael S. Rooney et al.

Review Immunology

The interaction of anticancer therapies with tumor-associated macrophages

Alberto Mantovani et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Article Reproductive Biology

Regulatory T lymphocytes and transforming growth factor beta in epithelial ovarian tumors-prognostic significance

Izabela Winkler et al.

JOURNAL OF OVARIAN RESEARCH (2015)

Article Medicine, General & Internal

Colorectal cancer

Hermann Brenner et al.

LANCET (2014)

Article Immunology

Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function

Jorg van Loosdregt et al.

IMMUNITY (2013)

Article Immunology

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Floriane Auderset et al.

JOURNAL OF IMMUNOLOGY (2013)

Article Biochemical Research Methods

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

Jeffrey T. Leek et al.

BIOINFORMATICS (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Computer Science, Interdisciplinary Applications

Regularization Paths for Generalized Linear Models via Coordinate Descent

Jerome Friedman et al.

JOURNAL OF STATISTICAL SOFTWARE (2010)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Review Immunology

Notch governing mature T cell differentiation

S Tsukumo et al.

JOURNAL OF IMMUNOLOGY (2004)