Journal
JOURNAL OF BIOPHOTONICS
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202300160
Keywords
5-aminolevulinic acid; acne; inflammatory skin lesions; photodynamic diagnosis; photodynamic therapy
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This study observed the fluorescence characteristics of acne inflammatory skin lesions in ALA-PDD and discussed its viability in evaluating these lesions and predicting subclinical skin lesions. The results showed that ALA-PDD is a feasible method for recognizing and evaluating inflammatory skin lesions, with advantages in predicting subclinical skin lesions.
Objective: This study aimed to observe the fluorescence characteristics of acne inflammatory skin lesions in 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD), and discuss the viability of using ALA-PDD to evaluate acne inflammatory skin lesions and explore the advantages of predicting subclinical skin lesions. Methods: The OBSERV facial skin detector collected photographs of 20 patients before and after optical intra-tissue fiber irradiation photodynamic therapy (OFI-ALA-PDT) in both ALA-PDD and white light patterns. The patients were treated once a week for four consecutive weeks in order to analyze the correlation between the two patterns in recognizing inflammatory skin lesions. Results: Before and after treatment, there was no significant difference between the two patterns for recognizing acne inflammatory skin lesions (p > 0.05). Both patterns demonstrated a strong correlation (r > 0.90) for the recognition of various types of inflammatory skin lesions at different treatment stages. Conclusion: ALA-PDD is a feasible method for evaluating acne inflammatory lesions, guiding treatment and judging efficacy. It has advantages in predicting subclinical skin lesions and deserves further study.
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