Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 25, Pages 5351-5354Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/C4CC08472A
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Funding
- Academy of Finland [263504, 267497, 273645]
- Biocentrum Helsinki and Emil Aaltonen Foundation
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In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units. We can controllably combine separate origami units equipped with glucose oxidase (GOx) and horseradish peroxidase (HRP), and demonstrate efficient GOx/HRP enzyme cascade reaction inside the tube. The reactor could be utilized as a nanoscale diagnostic tool, and modularity of the proposed system would further enable more complex reactions.
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