CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression

Article Biochemistry & Molecular Biology

Circ_C4orf36 Promotes the Proliferation and Osteogenic Differentiation of BMSCs by Regulating VEGFA

Zhi-Min Zhang et al.

Summary: This study found that circ_C4orf36 promoted cell proliferation, migration, and osteoblast differentiation by upregulating VEGFA expression, suggesting its potential as a target for fracture healing treatment.

BIOCHEMICAL GENETICS (2023)

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Article Cell Biology

CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p

Lingling Qiu et al.

Summary: This study revealed that circDLGAP4 alleviated OGD-induced HCN-2 cell damage in ischemic stroke (IS) by regulating the miR-503-3p/NEGR1 axis.

JOURNAL OF MOLECULAR HISTOLOGY (2022)

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Article Neurosciences

circDlgap4 Alleviates Cerebral Ischaemic Injury by Binding to AUF1 to Suppress Oxidative Stress and Neuroinflammation

Huan Liu et al.

Summary: This study investigated the function of circDlgap4 in ischaemic stroke and its underlying molecular mechanism. The results showed that circDlgap4 alleviated ischaemic injury by suppressing oxidative stress and neuroinflammation through binding to AUF1.

MOLECULAR NEUROBIOLOGY (2022)

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Article Pathology

Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27

Changpu Zhao et al.

Summary: This study reveals the important role of circular RNA circ_0000775 in the development of hepatocellular carcinoma (HC). TCF7L2 promotes the transcription of circ_0000775, and circ_0000775 enhances the migration, invasion, and epithelial-mesenchymal transition (EMT) of HC cells by recruiting IGF2BP2 to stabilize the mRNA of CDC27.

PATHOLOGY RESEARCH AND PRACTICE (2022)

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Article Cell Biology

LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression

Qian Zhou et al.

Aging-US (2021)

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Article Neurosciences

SOX21-AS1 modulates neuronal injury of MMP+-treated SH-SY5Y cells via targeting miR-7-5p and inhibiting IRS2

Yang Xie et al.

Summary: The study revealed a new regulatory network involving SOX21-AS1, miR-7-5p, and IRS2 in the pathogenesis of Parkinson's disease. Up-regulation of SOX21-AS1 exacerbated cell injury, while its depletion alleviated cell damage, providing new insights into the mechanism of PD.

NEUROSCIENCE LETTERS (2021)

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Article Neurosciences

HMGA1 Induction of miR-103/107 Forms a Negative Feedback Loop to Regulate Autophagy in MPTP Model of Parkinson's Disease

Gehui Li et al.

Summary: Autophagy dysfunction directly related to Parkinson's disease (PD) onset and progression, with high-mobility group A1 (HMGA1) playing a potential neuroprotective role in dopaminergic neurons by modulating autophagy signaling; the miR-103/107 family coordinates proper end-stage autophagy in neurons, while MPP+/MPTP-induced HMGA1 elevation forms a negative feedback loop with miR-103/107 downregulation to regulate autophagy impairment and neural cell death.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Review Oncology

Regulatory Effects of Circular RNAs on Host Genes in Human Cancer

Xiong Wang et al.

Summary: circRNAs, as a class of closed-loop RNAs, play significant roles in various aspects of cancer progression by modulating the expression or function of their host genes. This review summarizes the latest progress in understanding the interaction between circRNAs and their host genes in human cancer.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer

Shunhao Zhang et al.

Summary: Circular RNAs, a special type of noncoding RNA, exhibit high stability and potential gene regulation effects, playing roles in various biological functions and showing associations with the development and chemotherapy resistance of CRC.

CANCER MEDICINE (2021)

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Review Medicine, General & Internal

Parkinson's disease

Bastiaan R. Bloem et al.

Summary: Parkinson's disease is a neurodegenerative condition with diverse causes and clinical presentations. Diagnosis is clinically based, and treatment goals vary from person to person, emphasizing the need for personalized management. Currently, there is no therapy to slow down or arrest the progression of Parkinson's disease.

LANCET (2021)

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Review Clinical Neurology

Challenges in the diagnosis of Parkinson's disease

Eduardo Tolosa et al.

Summary: Parkinson's disease is the second most common neurodegenerative disease, with efforts being made to accurately diagnose and characterize it, including validation of diagnostic criteria and identification of genetic subtypes. Progress in diagnostic biomarkers has opened up possibilities for earlier identification, recognition of diverse subtypes, and development of novel treatments.

LANCET NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

Inflammation-Related circRNA Polymorphism and Ischemic Stroke Prognosis

Xu Liu et al.

Summary: The study identified a significant association between circ-STAT3 rs2293152 GG genotype and poorer recovery 90 days after ischemic stroke, highlighting its potential as a novel biomarker for predicting functional outcome after stroke. Other circRNA polymorphisms were not associated with functional outcomes and did not correlate with recurrent risk of ischemic stroke. Subgroup analysis revealed that the negative effect of rs2293152 GG genotype was greater in female and older patients, subjects with history of hypertension.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

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Article Oncology

Let-7b-5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2

Yujing Huang et al.

Summary: This study discovered that let-7b-5p promotes cell apoptosis in PD by targeting HMGA2, providing a potential theoretical basis for effective therapy in PD.

MOLECULAR MEDICINE REPORTS (2021)

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Article Endocrinology & Metabolism

Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy

Jie Yun et al.

Summary: The study revealed that circ-ACTR2 is upregulated in both DN samples and HG-treated HRMCs. Silencing circ-ACTR2 expression partially attenuated the effects of HG-induced cell proliferation, inflammation, extracellular matrix accumulation, and oxidative stress in HRMCs. Circ-ACTR2 acts as a sponge for miR-205-5p and regulates HG effects through miR-205-5p targeting HMGA2. The circ-ACTR2/miR-205-5p/HMGA2 axis contributes to HG-induced DN progression in HRMCs.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Review Geriatrics & Gerontology

The Emerging Role of Circular RNAs in Alzheimer's Disease and Parkinson's Disease

Meng Zhang et al.

Summary: Studies suggest that circRNAs could serve as promising biomarkers for early diagnosis of NDDs, such as AD and PD, and may lead to new therapeutic approaches targeting transcription for preventing neurodegeneration.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Biochemistry & Molecular Biology