4.7 Article

A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 55, Pages 11060-11063

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc03516c

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Funding

  1. National Institutes of Health [1R15EB014546-01A1]
  2. Coleman endowment from the University of Akron
  3. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R15EB014546] Funding Source: NIH RePORTER

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In this study, we report a series of novel flavone-based sensors that exhibit a superior fluorescence response when interacting with serum albumin in real serum samples and in acrylamide gels. The detection limit of probe 4 for serum albumin solution is 0.09 mu g mL(-1), and the detectable volume for monkey serum reaches as low as 0.03 mu L.

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