4.7 Article

A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 74, Pages 14038-14041

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05172j

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Funding

  1. Australian Research Council [DE130101650]
  2. Australian Microscopy & Microanalysis Research Facility (AMMRF)
  3. Australian Research Council [DE130101650] Funding Source: Australian Research Council

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We report a novel ruthenium(II) complex for selective release of the imidazole-based drug econazole. While the complex is highly stable and luminescent in the dark, irradiation with green light induces release of one of the econazole ligands, which is accompanied by a turn-off luminescence response and up to a 34-fold increase in cytotoxicity towards tumour cells.

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