Alzheimer's Disease and Sex-Dependent Alterations in the Striatum: A Lesson from a Mouse Model

In the last years, many clinical studies highlighted sex-specific differences in the pathophysiology of Alzheimer's disease (AD). The recent paper published in the Journal of Alzheimer's Disease shows the influence of sex on amyloid-beta plaque deposition, behavior, and dopaminergic signaling in the 5xFAD mouse model of AD, with worse alterations in female mice. This commentary focuses on the importance of recognizing sex as a key variable to consider for a more precise clinical practice, with the challenge to develop sex-specific therapeutic interventions in neurodegenerative diseases such as AD.

Automated summary

Recent studies have shown the significant influence of sex on the pathophysiology of AD, with worse alterations observed in female mice in terms of amyloid-beta plaque deposition, behavior, and dopaminergic signaling. Therefore, recognizing sex as a key variable is crucial for precise clinical practice and developing sex-specific therapeutic interventions.