☆ 4.5 Article

Circulating Exosomes from Alzheimer's Disease Suppress Vascular Endothelial-Cadherin Expression and Induce Barrier Dysfunction in Recipient Brain Microvascular Endothelial Cell

JOURNAL OF ALZHEIMERS DISEASE (2023)

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Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

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Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

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Sequence-Dependent Fluorescence of Cy3-and Cy5-Labeled Double-Stranded DNA

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Selective enrichment of microRNAs in extracellular matrix vesicles produced by growth plate chondrocytes

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BONE (2016)

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Reversible HuR-microRNA binding controls extracellular export of miR-122 and augments stress response

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EMBO REPORTS (2016)

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Extracellular vesicles and infectious diseases: new complexity to an old story

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Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption

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The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

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CELL REPORTS (2016)

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Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

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ELIFE (2016)

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Genes associated with Alzheimer's disease: an overview and current status

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CLINICAL INTERVENTIONS IN AGING (2016)

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Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

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Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes

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CANCER LETTERS (2015)

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Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles

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Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

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NEURON (2015)

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Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines

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Transmembrane proteins of the tight junctions at the blood-brain barrier: Structural and functional aspects

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

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Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

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NATURE COMMUNICATIONS (2015)

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Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

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KRAS-dependent sorting of miRNA to exosomes

Diana J. Cha et al.

ELIFE (2015)

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Use of labeled tomato lectin for imaging vasculature structures

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Optimized exosome isolation protocol for cell culture supernatant and human plasma

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Biogenesis, delivery, and function of extracellular RNA

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The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

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The role of senescent cells in ageing

Jan M. van Deursen

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Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

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Global Epidemiology of Dementia: Alzheimer's and Vascular Types

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FRONTIERS IN NEUROSCIENCE (2014)

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You Shall Not Pass-tight junctions of the blood brain barrier

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Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

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NATURE CELL BIOLOGY (2013)

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Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

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RNA BIOLOGY (2013)

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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

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National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

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The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis

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CCL2 disrupts the adherens junction: implications for neuroinflammation

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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

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ALZHEIMERS & DEMENTIA (2011)

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Microfluidic-Based Multiplex qRT-PCR Identifies Diagnostic and Prognostic microRNA Signatures in the Sera of Prostate Cancer Patients

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Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

Paula Grammas

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Berislav V. Zlokovic

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Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

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VE-cadherin - The major endothelial adhesion molecule controlling cellular junctions and blood vessel formation

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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7

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Chemokine signaling via the CXCR2 receptor reinforces senescence

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Wnt/β-catenin signaling controls development of the blood-brain barrier

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Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

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Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Alzheimer's disease β-amyloid peptides are released in association with exosomes

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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MicroRNA expression profiling of single whole embryonic stem cells

FC Tang et al.

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The tight junction protein occludin and the adherens junction protein α-catenin share a common interaction mechanism with ZO-1

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Inflammatory response - Pathway across the blood-brain barrier

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