Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies

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A comprehensive review of the therapeutic potential of citrus bioflavonoid hesperidin against lifestyle-related disorders

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Summary: The fruits of the citrus family are rich in flavonoids, which have superior antioxidant properties. Citrus bioactive components have the potential to be beneficial and have no adverse effects or cytotoxicity in healthy individuals. Hesperidin, a flavanone glycoside found in citrus fruit peel, has shown effective roles as an antioxidant and anti-inflammatory bioactive compound in biological systems. Different studies have investigated these roles of hesperidin.

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Lipid pathway dysfunction is prevalent in patients with Parkinson's disease

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Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases

Jasmine A. Evans et al.

Summary: Neurodegenerative disorders are a serious health threat, and neuroinflammation and oxidative stress play critical roles in their onset, progression, and pathogenesis. Hesperetin, an aglycone of hesperidin found in citrus fruits, has been shown to have neuroprotective effects in experimental models of neurodegenerative diseases, and can modulate the release of cellular anti-inflammatory and antioxidative stress mediators.

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Baicalein exhibits differential effects and mechanisms towards disruption of α-synuclein fibrils with different polymorphs

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Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS-CoV-2 Spike Protein 51 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway

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Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice

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Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies

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