Related references
Note: Only part of the references are listed.
Review
Food Science & Technology
Silu Hou et al.
Summary: This article reviews the toxic mechanisms of deoxynivalenol (DON), a mycotoxin that contaminates cereal crops, and discusses methods to prevent and reduce its toxicity. Mitochondria are an important target of DON, and DON can indirectly cause mitochondrial damage and changes through various means. Biological detoxification and the antioxidant effect of natural products show potential as effective treatments for DON toxicity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Environmental Sciences
Xue Rong et al.
Summary: The co-exposure of zearalenone and deoxynivalenol had toxic effects on zebrafish embryos, leading to decreased movement and heartbeat, developmental toxicity, oxidative stress, hepatotoxicity, apoptosis, and inflammation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Wenyan Yu et al.
Summary: In this study, a fluorescence and surface-enhanced Raman scattering (FL-SERS) dual-mode aptasensor was developed for the ultrasensitive detection of deoxynivalenol (DON). The aptasensor utilized gold nanoclusters and silver nanoparticles modified metal polydopamine framework. The results showed that the aptasensor exhibited a low detection limit and good reliability, and it was successfully applied for DON detection in wheat flour.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yue Jia et al.
Summary: A biosensor was fabricated using mesoporous silica nanosphere (MSN) matrix-confined 1,1,2,2-tetra(4-carboxylphenyl)ethylene (TPE) as an ordered electrochemiluminescence (ECL) emitter and a self-designed WC-7 heptapeptide as the target capturer for CD44 detection. The use of aggregation-induced electrochemiluminescence (AIECL) theory and the MSN-TPE-TEA system improved the reproducibility and consistency of biosensors, making it a stable signal label for trace analysis of biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Bing Li et al.
Summary: In this study, a novel split-type electrochemical immunosensor based on controlled release strategy was proposed for sensitive analysis and detection of tumor marker carbohydrate antigen 199 (CA19-9). The immunosensor showed wide linear concentration range and highly sensitive detection of CA19-9. It provides an innovative approach for trace detection of other biomarkers.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Environmental Sciences
Xu Ji et al.
Summary: In this study, taurine supplementation was found to improve DON-induced liver injury in weaned piglets by reducing pathological and serum biochemical changes, attenuating oxidative stress and inflammation, and inhibiting hepatocyte apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Applied
Fuheng You et al.
Summary: An electrochemiluminescence (ECL) DON aptasensor based on Ti3C2 dots/Ti3C2 nanosheet (TDTN) was developed, showing high sensitivity and specific detection for deoxynivalenol (DON). The ECL aptasensor exhibited promising potential for food safety analysis.
Article
Agriculture, Multidisciplinary
Fang Gan et al.
Summary: This study evaluated the effects of a nontoxic dose of DON on DSS-induced colitis in mice and the underlying mechanism. The results showed that a nontoxic dose of DON exacerbated DSS-induced colitis in mice, characterized by increased disease activity index, colon length reduction, increased morphological damage, decreased occludin and mucoprotein 2 expression, increased IL-1 beta and TNF-alpha expression, and decreased IL-10 expression. The study suggests that a nontoxic dose of DON can aggravate DSS-induced colitis through the JAK2/STAT3 signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Yongsong Bai et al.
Summary: This study demonstrates that Lactobacillus rhamnosus GG (LGG) improves deoxynivalenol (DON)-induced anorexia by modulating gut microbiota. LGG enhances intestinal barrier function, reduces intestinal inflammation, promotes food intake, and decreases weight loss. Antibiotic treatment and fecal microbiota transplant experiments confirm that gut microbiota is the primary vector for DON toxic effects and an essential mediator of LGG protection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Environmental
Bingxuan Jia et al.
Summary: In this study, we found that Deoxynivalenol (DON) inhibited animal growth and caused damage to the intestine, liver, and kidney. DON induced intestinal flora disorders in both chickens and pigs, and the changes in the flora were mainly related to metabolic and digestive functions. Comparative analysis suggested that Prevotella may play an important role in maintaining intestinal health, and DON may have different toxicity modes in different animals.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Kai Wang et al.
Summary: A label-free aptasensor using cerium-based metal-organic framework composite gold nanoparticles was developed for detecting vomitoxin residues in grains. The aptasensor achieved the separation of the DON-aptamer complex and cDNA using magnetic separation technique with magnetic beads, ensuring specificity. Exonuclease III-assisted cDNA cycling process strategy was triggered for signal amplification. The aptasensor showed a wide detection range and a low detection limit, indicating its reliability and potential in DON detection.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Jinjin Wang et al.
Summary: This study presents a new dual-signal amplified cathodic electrochemiluminescence (ECL) biosensor for the ultrasensitive detection of zearalenone (ZEN) in maize, which is of significant importance in preventing mycotoxin contamination in cereals.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Materials Science, Ceramics
Meng-Xin Ren et al.
Summary: The combination of nitrogen-doped carbon shell or graphene with mesoporous structure significantly enhances the electrochemical properties of the composite materials. The synthesis of mesoporous silicon nanocubes coated by nitrogen-doped carbon shell or wrapped by graphene addresses the challenges of large volumetric expansion and poor electrical conductivity, resulting in improved stability and specific capacities of the electrode materials.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Rong Tan et al.
Summary: This study presents a novel dual-screening sensing strategy based on specific aptamer recognition and mesoporous silica membrane (MSM) nano-sieving for the detection of A/3, which enhances the specificity and sensitivity of detection, aiding in monitoring the occurrence and development of Alzheimer's disease.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Food Science & Technology
Ehsan Feizollahi et al.
Summary: There are various methods for degrading deoxynivalenol (DON), each with different degradation efficacy and byproducts. Studying the effects of these degradation methods on DON, understanding the formation mechanisms and toxicity of the byproducts, can help in selecting the best method to overcome DON contamination in grains.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Engineering, Environmental
Feng Hong et al.
Summary: Inspired by the stability and biocompatibility of polydopamine, a universal, portable, and ultra-sensitive pipet immunoassay platform was developed for the detection of the highly toxic mycotoxin deoxynivalenol (DON). The platform showed high sensitivity, reduced detection cost, and simplified experimental steps.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Guohua Xu et al.
Summary: This research reports the solution structure of a DNA aptamer complexed with ochratoxin A (OTA), revealing the structural basis for its high-affinity binding. The study finds that OTA specifically binds at the junction between the double helix and G-quadruplex through pi-pi stacking, halogen bonding, and hydrophobic interaction. The presence of a strong halogen bond between OTA and the aptamer is the key to discriminating the strong binding toward OTA.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Food Science & Technology
Ye Tian et al.
Summary: The review article summarized recent research on microbial and enzymatic methods for eliminating Fusarium mycotoxin DON, highlighting the potential of biological approaches for DON detoxification. The proposed conceptual framework combining computational tools with multi-omics approaches for discovering DON detoxification enzymes provides a new foundation for future mycotoxin detoxification research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Applied
Mengke Xia et al.
Summary: In this study, a novel and credible electrochemiluminescence immunoassay (ECLIA) was developed for the ultrasensitive and highly selective detection of aflatoxin B-1 (AFB(1)). The combination of amino-functionalized 3D graphene hydrogel (NGH) and self-enhanced ECL of luminol-palladium-graphene oxide (lum-Pd-GO) served as the platform and marker, respectively. The developed ECLIA exhibited low detection limit and broad linear relationship, and was successfully applied for the analysis of AFB(1) contents in food samples.
Article
Engineering, Environmental
Xianfeng Lin et al.
Summary: In this study, a sensitive and robust CRISPR-Cas12a-mediated aptasensor was developed to detect DON using labeled nanoparticles and enhanced quenchers. The sensor enables accurate analysis of DON and expands the detection range of CRISPR-Cas sensors for nonnucleic acid hazards in the environment and food.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Nuo Duan et al.
Summary: Aptamers with high affinity to DON were selected and used to fabricate a sensitive aptasensor for DON detection. The practical application of this method in maize flour samples showed satisfactory recovery.
Article
Biophysics
Xudong Zhao et al.
Summary: In this study, a novel bionic magnetic SERS aptasensor based on dual antennae nano-silver was designed for efficient, sensitive and selective detection of deoxynivalenol (DON). The specific recognition and competitive binding of DON and aptamer, combined with magnetic separation and enhanced Raman scattering techniques, resulted in a lower SERS intensity, with a good linear relationship between the SERS intensity and the logarithm of DON concentration. The SERS aptasensor exhibited good selectivity, repeatability and practicability, showing great application potential in toxin detection and biochemical analysis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Environmental Sciences
Jie Han et al.
Summary: An ultrasensitive electrochemiluminescence aptasensor was developed and successfully applied to the detection of profenofos in vegetables. The sensor exhibited a low limit of detection and good specificity, making it a promising tool for pesticide detection.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Binxiao Li et al.
Summary: In this study, a designed Ru(bpy)(3)(2+) embedded MOF complex (RuMOFs) is used for high-quality imaging of electrochemiluminescence (ECL) events at a single molecule level. The efficient capture of ECL photons generated inside the MOFs allows for stable ECL emission for up to 1 hour, enabling the visualization of protein movements at the cellular membrane. Compared to fluorescence observation, the near-zero ECL background provides better contrast for dynamic imaging of discrete protein movement.
Article
Chemistry, Analytical
Ran Chen et al.
Summary: This study presents a model for the electrochemical oxidation of luminol and investigates the electron transfer kinetics in alkaline solutions using a finite element method simulation. The results show that pH and molecular structure influence the oxidation and adsorption effects of luminol. In addition, the study reveals that the ECL intensity can be enhanced through adsorption effects.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Jie Cheng et al.
Summary: BUT-16 demonstrates excellent adsorption capacity for DON, with the ability to effectively adsorb and remove DON in simulated gastric fluid but showing low desorption in simulated intestinal fluid. This suggests promising applications for BUT-16 in controlling DON in foods and feeds.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Estela Climent et al.
Summary: The research developed a simple and generic method that combines ECL and gAID technologies to rapidly detect ultra-trace levels of penicillin in milk using modified nanomaterials, with higher sensitivity, measurement uncertainty, and robustness compared to traditional fluorescence or electrochemical detection methods.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biophysics
Hassan Nasrollahpour et al.
Summary: The study developed an ECL-based cytosensor for quantifying metastatic breast cancer cells, utilizing silica-based mesoporous materials for electrode preparation. The sensor showed good specificity and repeatability, making it suitable for clinical applications in combination with microfluidic systems for the detection and separation of metastatic cells.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Junyong Sun et al.
Summary: The study introduces a novel flower-like core-shell mesoporous silica nanospheres@zeolitic imidazolate framework-8 (MSN@ZIF-8) hybrid electrocatalyst with hierarchical framework, enhanced porosity, tunable functionality, and excellent stability. A molecularly imprinted electrochemical sensor based on MSN@ZIF-8 nanocomposites was developed with wide linear range, subnanomolar detection limit, and specific selectivity for atropine monitoring. Further research on porous electrocatalysts with improved stability and performance for various sensor applications is highly anticipated.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Meng Zhang et al.
Summary: A sensitive photothermal immunochromatographic test strip (PITS) for the detection of deoxynivalenol (DON) was developed using flower-like gold nanoparticle-deposited manganese dioxide nanocarrier (FMD-G NC) labeled antibodies (Abs) as the photothermal-sensing probe. The PITS exhibited sensitive and specific detection of DON with detection limits of 0.013 ng mL(-1), which were over 15-fold and 58-fold more sensitive than visual FMD-G-ITS and traditional GNPs-ITS, showing its potential as a universal applicability for various food samples.
Article
Food Science & Technology
Ying Deng et al.
Summary: This study systematically evaluated the characteristics of human DON and DON-3G biomarkers, revealing that children and adolescents have higher levels of DON exposure compared to adults, while the elderly have the lowest levels, suggesting that young people, including children, face greater health risks. Pregnant women may transmit DON through the placental barrier from mothers, potentially inhibiting fetal growth and immune function. The vegetarian population is at higher risk of exposure to DON and DON-3G due to their greater consumption of vegetables and cereals.
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Jiawei Peng et al.
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