☆ 4.7 Article

Design, Synthesis, Insecticidal Activity, and SAR of Aryl Isoxazoline Derivatives Containing Pyrazole-5-carboxamide Motif

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Related references

Note: Only part of the references are listed.

Article Agriculture, Multidisciplinary

Potential Fungicide Candidates: A Dual Action Mode Study of Novel Pyrazole-4-carboxamides against Gibberella zeae

Chengzhi Zhang et al.

Summary: A series of novel 1,5-disubstituted-1H-pyrazole-4-carboxamide derivatives were designed and synthesized, which exhibited excellent in vitro antifungal activities against six phytopathogenic fungi. The compound Y47 showed significant SDH inhibition activity and could affect the membrane integrity of mycelium, exhibiting dual action modes. This research provides a novel approach to the development of traditional SDHIs and their derivatives.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Add to Collection

Article Agriculture, Multidisciplinary

Design, Synthesis, and Insecticidal and Fungicidal Activities of Ether/Oxime-ether Containing Isoxazoline Derivatives

Shisheng Huang et al.

Summary: Isoxazoline derivatives are new insecticides that have unique insecticidal mechanisms, high selectivity, safety, and no cross resistance with existing pesticides. Through the investigation of insecticidal activity and structure-activity relationship, several compounds with high insecticidal activities were found and considered as novel insecticide candidates.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Add to Collection

Article Agriculture, Multidisciplinary

Discovery of Novel Isoxazoline Compounds that Incorporate a para- Diamide Moiety as Potential Insecticidal Agents against Fall Armyworm (Spodoptera frugiperda)

Biaobiao Jiang et al.

Summary: A series of novel isoxazoline derivatives were designed and synthesized to discover potent compounds against Spodoptera frugiperda. Through quantitative structure-activity relationship analysis, compound G22 was found to have a high lethality against S. frugiperda and was more effective than commonly used insecticides fipronil and chlorantraniliprole. This study provides a potent isoxazoline candidate compound for S. frugiperda control.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Add to Collection

Article Agronomy

Activity, selection response and molecular mode of action of the isoxazoline afoxolaner in Tetranychus urticae

Catherine Mermans et al.

Summary: Afoxolaner demonstrated strong antagonistic activity against GABACls of T. urticae, making it a powerful tool for controlling spider mites. In contrast, other drugs such as fluralaner, fipronil, and endosulfan showed minimal antagonistic activities against GABACls channels of T. urticae.

PEST MANAGEMENT SCIENCE (2023)

Add to Collection

Article Agronomy

Design, synthesis, and insecticidal and fungicidal activities of quaternary ammonium salt derivatives of a triazolyphenyl isoxazoline insecticide

Shi-sheng Huang et al.

Summary: In this study, a series of quaternary ammonium salt derivatives were designed and synthesized, and their insecticidal and antifungal activities were evaluated. Many of the synthesized compounds exhibited excellent activities against various pests and fungi, with compounds I-31 and I-34 showing better insecticidal activities than commonly used insecticides fluralaner and DP-9.

PEST MANAGEMENT SCIENCE (2022)

Add to Collection

Article Engineering, Chemical

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif

Yong-Hui Wen et al.

Summary: Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesized and their chemical structures were confirmed. Some of these compounds showed excellent insecticidal activity against Mythimna separate, but were inactive against Aphis medicagini and Tetranychus cinnabarinus. The study discussed the structure-insecticidal activity relationships and suggested the potential use of density functional theory analysis for designing more active compounds. These findings provide valuable information for further optimization of insecticides.

FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Novel Dioxolane Ring Compounds for the Management of Phytopathogen Diseases as Ergosterol Biosynthesis Inhibitors :Synthesis, Biological Activities, and Molecular Docking

Li-Jing Min et al.

Summary: In this study, thirty novel dioxolane ring compounds were designed and synthesized. Their chemical structures were confirmed, and bioassays showed that these compounds exhibited excellent fungicidal and herbicidal activity. The study also revealed their target in plants and the mechanism of enzyme inhibition. The structure-activity relationships were discussed, providing useful information for designing more active compounds.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Add to Collection

Article Multidisciplinary Sciences

Multi-centre discriminating concentration determination of broflanilide and potential for cross-resistance to other public health insecticides in Anopheles vector populations

Natalie M. Portwood et al.

Summary: This study expanded upon the testing of broflanilide's discriminating concentration and found it to be effective as an indoor residual spraying product against pyrethroid-resistant vector populations. The study also investigated the potential for cross-resistance to broflanilide via a specific mutation, but no cross-resistance was observed. These findings provide important insights for ongoing community trials of broflanilide in Tanzania and Benin.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

High frequency of ryanodine receptor and cytochrome P450 CYP9A186 mutations in insecticide-resistant field populations of Spodoptera exigua from China

Haiyuan Teng et al.

Summary: The beet armyworm, a global agricultural pest, has developed resistance to insecticides such as chlorantraniliprole and emamectin benzoate. Mutations in specific genes, such as SeRyR and CYP9A186, have been found to contribute to resistance. However, the resistance mechanisms may vary for different insecticides. Therefore, the use of insecticides with different modes of action and other integrated pest management strategies are necessary to effectively control the beet armyworm in China.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Novel Pyrazole Carboxamide Containing a Diarylamine Scaffold Potentially Targeting Fungal Succinate Dehydrogenase: Antifungal Activity and Mechanism of Action

Yongtian Zhao et al.

Summary: Compound SCU3038 is a potent SDH inhibitor with good antifungal activity against Rhizoctonia solani and effective control efficacy against rice sheath blight. Its mechanism of action may involve inhibiting fungal SDH, affecting the TCA cycle pathway in mitochondria, and reducing the mitochondria of R. solani.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Discovery of N-Methoxy-(biphenyl-ethyl)-pyrazole-carboxamides as Novel Succinate Dehydrogenase Inhibitors

Yuan-Hui Huang et al.

Summary: The study successfully enhanced the fungicidal activity by designing N-methoxy-(biphenyl-ethyl)-pyrazole-carboxamide derivatives. Compound 7s showed the highest activity against porcine SDH and compound 7u exhibited potent fungicidal activity against wheat powdery mildew.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Synthesis, crystal structure, herbicidal activity and mode of action of new cyclopropane-1,1-dicarboxylic acid analogues

Li-Jing Min et al.

Summary: A new series of CPD acid analogues were designed and synthesized. These compounds exhibited low herbicidal activity against lettuce and bentgrass, but N,N'-bis(2-ethylphenyl)cyclopropane-1,1-dicarboxamide showed moderate activity against bentgrass. Experimental and simulation results supported the inhibition of KARI activity as their mode of action.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The mode of action of isocycloseram: A novel isoxazoline insecticide

Judith Blythe et al.

Summary: Isocycloseram is a novel isoxazoline insecticide and acaricide that targets the invertebrate Rdl GABA receptor. It has shown activity against various pest species and is not affected by the widely distributed cyclodiene resistance mutation. Binding sites relevant to its insecticidal activity are distinct from avermectins. In addition, specific mutations in the Rdl GABA receptor impair its ability to block the GABA mediated response, indicating its unique mode of action.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Design, Synthesis, and Pesticidal Activities of Pyrimidin-4-amine Derivatives Bearing a 5-(Trifluoromethyl)-1,2,4-oxadiazole Moiety

Xing-Hai Liu et al.

Summary: The study designed and synthesized a series of novel pyrimidin-4-amine derivatives with good insecticidal and fungicidal activities. Among them, compounds U7 and U8 showed broad-spectrum activity, and further optimization is possible. The structure-activity relationships were discussed, and density functional theory analysis may help design more active compounds.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Add to Collection

Article Agronomy

Synthesis and herbicidal activity of novel pyrazole aromatic ketone analogs as HPPD inhibitor

Qing Fu et al.

PEST MANAGEMENT SCIENCE (2020)

Add to Collection

Article Agronomy

Lethal and sublethal effects of fluralaner on the two-spotted spider mites, Tetranychus urticae Koch (Acari: Tetranychidae)

Kipchoge Leviticus et al.

PEST MANAGEMENT SCIENCE (2020)

Add to Collection

Article Agriculture, Multidisciplinary

Enantioselective Detection, Bioactivity, and Metabolism of the Novel Chiral Insecticide Fluralaner

Zhaoxian Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Add to Collection

Article Agronomy

Neurotoxicity and mode of action of fluralaner on honeybee Apis mellifera L.

Cheng-Wang Sheng et al.

PEST MANAGEMENT SCIENCE (2019)

Add to Collection

Article Agronomy

Novel 4-pyrazole carboxamide derivatives containing flexible chain motif: design, synthesis and antifungal activity

Xing-Hai Liu et al.

PEST MANAGEMENT SCIENCE (2019)

Add to Collection

Article Chemistry, Organic

Synthesis, Crystal Structure, Antifungal Activity, and Docking Study of Difluoromethyl Pyrazole Derivatives

Li Qiao et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Fluxametamide: A novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels

Miho Asahi et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2018)

Add to Collection

Article Engineering, Chemical

Synthesis and in vivo nematocidal evaluation of novel 3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

Wen Zhao et al.

FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING (2017)

Add to Collection

Article Chemistry, Medicinal

Synthesis, nematocidal activity and SAR study of novel difluoromethylpyrazole carboxamide derivatives containing flexible alkyl chain moieties

Xing-Hai Liu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Add to Collection

Article Entomology

Insecticidal spectrum of fluralaner to agricultural and sanitary pests

Cheng-Wang Sheng et al.

JOURNAL OF ASIA-PACIFIC ENTOMOLOGY (2017)

Add to Collection

Editorial Material Parasitology

Lotilaner - a novel systemic tick and flea control product for dogs

Susan E. Little

PARASITES & VECTORS (2017)

Add to Collection

Article Environmental Sciences

Mosquitocidal Activity and Mode of Action of the Isoxazoline Fluralaner

Shiyao Jiang et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

Add to Collection

Article Entomology

Insecticidal spectrum of fluralaner to agricultural and sanitary pests

Cheng-Wang Sheng et al.

JOURNAL OF ASIA-PACIFIC ENTOMOLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors

Steven D. Buckingham et al.

CURRENT MEDICINAL CHEMISTRY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Broflanilide: A meta-diamide insecticide with a novel mode of action

Toshifumi Nakao et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Add to Collection

Article Chemistry, Medicinal

Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

Michael P. Curtis et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Add to Collection

Article Chemistry, Medicinal

Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

Xing-Hai Liu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Add to Collection

Article Biochemistry & Molecular Biology

The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity

Michael Gassel et al.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Add to Collection

Article Chemistry, Medicinal

The Calculation of Molecular Structural Similarity: Principles and Practice

Peter Willett

MOLECULAR INFORMATICS (2014)

Add to Collection

Article Chemistry, Medicinal

New GABA/Glutamate Receptor Target for [3H]Isoxazoline Insecticide

Pablo Garcia-Reynaga et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2013)

Add to Collection

© Peeref 2019-2024. All rights reserved.