National Network of Depression Centers position statement: Insurance coverage for intravenous ketamine in treatment-resistant major depressive disorder

Article Medicine, General & Internal

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression

Amit Anand et al.

Summary: This study compared the effectiveness of electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine for treatment-resistant major depression. The results showed that ketamine was noninferior to ECT in the treatment of resistant depression without psychosis.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Article Psychology, Clinical

Comparative Effectiveness of Intravenous Ketamine and Intranasal Esketamine in Clinical Practice Among Patients With Treatment-Refractory Depression: An Observational Study

Balwinder Singh et al.

Summary: This study compared the efficacy and time to achieve remission/response between intravenous ketamine and intranasal esketamine for treatment-resistant depression. The results showed similar rates of response and remission between the two treatment methods, but intravenous ketamine required significantly fewer treatments to achieve remission than intranasal esketamine.

JOURNAL OF CLINICAL PSYCHIATRY (2023)

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Review Psychiatry

Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis

Yazen Alnefeesi et al.

Summary: Ketamine shows promising clinical effectiveness in the treatment of treatment-resistant depression (TRD), as demonstrated by a systematic review and meta-analysis. The study findings indicate a substantial mean antidepressant effect, with potential benefits for even the most treatment-resistant patients.

JOURNAL OF PSYCHIATRIC RESEARCH (2022)

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Review Psychiatry

Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode A Systematic Review and Meta-analysis

Taeho Greg Rhee et al.

Summary: The systematic review and meta-analysis suggest that ECT may be more effective than ketamine in improving the severity of depression in the acute phase, but treatment options should be individualized and patient-centered.

JAMA PSYCHIATRY (2022)

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Review Clinical Neurology

Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis

Anees Bahji et al.

Summary: The study showed that intravenous racemic ketamine was more effective and better tolerated than intranasal esketamine for the treatment of unipolar and bipolar major depression.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Psychiatry