Frontoparietal network homogeneity as a biomarker for mania and remitted bipolar disorder and a predictor of early treatment response in bipolar mania patient

Editorial Material Neurosciences

A shared pathway connects schizophrenia and bipolar disorder

Jake Rogers

NATURE REVIEWS NEUROSCIENCE (2023)

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Letter Psychiatry

The Artificial intelligence large language models and neuropsychiatry practice and research ethic

Yi Zhong et al.

ASIAN JOURNAL OF PSYCHIATRY (2023)

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Article Clinical Neurology

Decreased dorsal attention network homogeneity as a potential neuroimaging biomarker for major depressive disorder

Yujun Gao et al.

Summary: This study aimed to explore the changes in brain network homogeneity (NH) in patients with major depressive disorder (MDD) and determine the role of this parameter in differentiating between MDD patients and healthy controls. The results showed reduced NH in the left supramarginal gyrus (SMG) in MDD patients compared to healthy controls. Support vector machine analysis revealed that the NH of the left SMG could effectively differentiate between MDD patients and healthy controls with high accuracy, specificity, and sensitivity. These findings suggest that NH changes in the dorsal attention network may serve as a neuroimaging biomarker for distinguishing MDD patients from healthy individuals.

JOURNAL OF AFFECTIVE DISORDERS (2023)

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Article Neurosciences

Abnormal Degree Centrality as a Potential Imaging Biomarker for Right Temporal Lobe Epilepsy: A Resting-state Functional Magnetic Resonance Imaging Study and Support Vector Machine Analysis

Yujun Gao et al.

Summary: This study found abnormal functional connectivity in patients with right temporal lobe epilepsy (rTLE), and the analysis of these abnormalities can be used for the diagnosis of the disease.

NEUROSCIENCE (2022)

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Editorial Material Medicine, General & Internal

In the Clinic Bipolar Disorder

Mark S. Bauer

ANNALS OF INTERNAL MEDICINE (2022)

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Article Clinical Neurology

Pro-inflammatory cytokines and cognitive dysfunction among patients with bipolar disorder and major depression

Mao-Hsuan Huang et al.

Summary: This study found that patients with bipolar I disorder had higher levels of soluble tumor necrosis factor receptor 1 and cognitive function impairments compared to patients with major depressive disorder and the control group.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2022)

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Article Multidisciplinary Sciences

Maturation and circuit integration of transplanted human cortical organoids

Omer Revah et al.

Summary: This study demonstrates the potential of transplanting self-organizing neural organoids derived from human stem cells into the somatosensory cortex of rats to develop mature cell types and integrate into sensory and motivation-related circuits. The transplanted cortical neurons exhibit more complex properties than their in vitro counterparts and can drive reward-seeking behavior when optogenetically activated. This approach has the potential to detect circuit-level phenotypes in patient-derived cells that cannot be uncovered using other methods.

NATURE (2022)

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Article Psychiatry

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

Yujun Gao et al.

Summary: This study found that patients with schizophrenia show reduced ALFF values in specific brain regions compared to healthy controls. The support vector machine (SVM) analysis identified that reductions in ALFF values in the bilateral precuneus (PCu) can effectively differentiate between schizophrenia patients and healthy controls.

FRONTIERS IN PSYCHIATRY (2022)

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Article Psychiatry

Abnormal degree centrality values as a potential imaging biomarker for major depressive disorder: A resting-state functional magnetic resonance imaging study and support vector machine analysis

Hang Lin et al.

Summary: This study revealed abnormal degree centrality (DC) in patients with major depressive disorder (MDD) using resting-state functional magnetic resonance imaging (rs-fMRI). The researchers identified the left anterior cerebellar lobe and right caudate as potential imaging biomarkers for the diagnosis of MDD.

FRONTIERS IN PSYCHIATRY (2022)

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Article Psychiatry

Abnormal degree centrality in first-episode medication-free adolescent depression at rest: A functional magnetic resonance imaging study and support vector machine analysis

Xin Guo et al.

Summary: This study investigates the relationship between adolescent depression and whole-brain network centrality abnormalities, and finds that changes in brain voxel-level functional connectivity may be a potential biomarker for adolescent depression.

FRONTIERS IN PSYCHIATRY (2022)

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Article Psychiatry

Testing the validity and reliability of the Chinese version of the Staden schizophrenia anxiety rating scale

Chenyuan Du et al.

Summary: Accurate assessment of anxiety disorders and their symptoms in schizophrenic patients is crucial for prognosis and treatment. Traditional anxiety assessment scales are considered unsuitable for evaluating anxiety symptoms in patients with schizophrenia, while the S-SARS has shown reliability in measuring specified and undifferentiated anxiety in schizophrenia. This study tested the reliability and validity of the Chinese version of S-SARS and found that it demonstrated good structural validity and reliability, and better criterion validity compared to HAMA. The S-SARS and its Chinese version can serve as effective tools for assessing anxiety symptoms in schizophrenia.

FRONTIERS IN PSYCHIATRY (2022)

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Article Clinical Neurology

Clinical and neuroimaging correlates of cardiorespiratory fitness in adolescents with bipolar disorder

Najla Popel et al.

Summary: The study found that adolescents with bipolar disorder had significantly lower cardiorespiratory fitness, particularly among women, which was related to depression symptoms and inactivity. Additionally, the research showed that CRF was differently associated with regional brain structure, and improving CRF may be a promising approach to reducing psychiatric symptoms of BD.

BIPOLAR DISORDERS (2021)

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Article Immunology

Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients

Huai-Hsuan Tseng et al.

Summary: Patients with bipolar disorder may be particularly sensitive to the effects of peripheral inflammation on corticostriatal connectivity, which may affect cognitive and reward-related corticostriatal circuitry, contributing to cognitive-affective dysregulation in the euthymic state. Therefore, anti-inflammatory or other circuit-specific treatments are warranted for individualized treatment in bipolar disorder.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Clinical Neurology

Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients

Zhifang Zhang et al.

Summary: The study revealed that BD patients exhibited increased ALFF in the right caudate/putamen and increased rsFC in the right caudate/putamen with the right inferior parietal lobe. Furthermore, euthymic BD patients showed similar abnormalities in ALFF and rsFC maps as found in all patients with BD. This suggests that the abnormality of spontaneous brain activity in the cortical-striatal neural circuits may be a trait-like variant in patients with BD.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

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Article Clinical Neurology

Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study

Li Zhang et al.

Summary: Using graph theoretical methods with functional magnetic resonance imaging data, this study examined the topological organization of brain networks in bipolar disorder across different mood states. Abnormalities were found at the global, module, and nodal levels, particularly in the frontoparietal-limbic circuit, reflecting potential biomarkers of conversion between different mood states in bipolar disorder.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2021)

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Article Clinical Neurology

Different facial recognition patterns in schizophrenia and bipolar disorder assessed using a computerized emotional perception test and fMRI

Hyun Chan Hwang et al.

Summary: The study found that schizophrenic patients have lower emotional perception abilities compared to bipolar disorder patients, indicating disrupted emotional perception abilities are linked to altered brain functional connectivity. Schizophrenic patients show reduced usage of the frontal lobe, while bipolar patients compensate for facial emotion recognition using the parietal lobe.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Review Clinical Neurology

DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis-A narrative review from the ECNP bipolar disorders network

Lars Vedel Kessing et al.

Summary: This narrative review discusses the impact of DSM-5 and ICD-11 classification systems on the prevalence and validity of bipolar disorder diagnosis. It suggests a significant decrease in the point prevalence of bipolar disorder with DSM-5 compared to DSM-IV, but a smaller decrease in lifetime prevalence. Future research is needed to explore the implications of these diagnostic systems on bipolar disorder.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

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Article Clinical Neurology

Gender differences of amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study

Xuejun Jiang et al.

Summary: This study investigated the association between brain function and gender in bipolar disorder using amplitude of low-frequency fluctuations (ALFF). The results indicated gender differences in dysfunction of the cortico-limbic neural system in BD. Male and female patients with BD showed different patterns of ALFF in various brain regions.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Clinical Neurology

Clinical and neurostructural characteristics among youth with familial and non-familial bipolar disorder Family history and youth bipolar disorder

Weicong Lu et al.

Summary: There were relatively few differences in clinical and neurostructural correlates related to family history of BD in youth with BD. Current findings suggest that family history of BD is not a strong contributor to the clinical or neuroimaging phenotypes in youth with BD.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Altered Complexity of Spontaneous Brain Activity in Schizophrenia and Bipolar Disorder Patients

Nan Zhang et al.

Summary: The study found different patterns of brain signal intensity complexity in patients with schizophrenia (SC) and bipolar disorder (BP), with significant differences in complexity in different brain regions. Additionally, the complexity of certain regions was significantly correlated with regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF), while complexity in other regions was negatively correlated with cognitive assessment scores.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2021)

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Article Clinical Neurology

Abnormal Fractional Amplitude of Low-Frequency Fluctuation as a Potential Imaging Biomarker for First-Episode Major Depressive Disorder: A Resting-State fMRI Study and Support Vector Machine Analysis

Yujun Gao et al.

Summary: This study investigated the clinical diagnostic value of fALFF based on SVM method for MDD diagnosis. Increased fALFF in the left mid cingulum, right precuneus, and left SFG may serve as a neuroimaging marker for first-episode MDD, with the combination of increased fALFF in right precuneus and left SFG showing the best diagnostic value.

FRONTIERS IN NEUROLOGY (2021)

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Review Behavioral Sciences

Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta -analysis

Carmen Schiweck et al.

Summary: ADHD and BD have a high degree of comorbidity in adults, with substantial heterogeneity in comorbidity rates. Patients with comorbid ADHD tend to have an earlier onset of BD. Cultural, geographical, and methodological differences should be considered for evaluating diagnostic criteria to prevent misdiagnosis and provide optimal care for both disorders.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Review Clinical Neurology

Large-scale network abnormality in bipolar disorder: A multimodal meta-analysis of resting-state functional and structural magnetic resonance imaging studies

Jiaying Gong et al.

Summary: This study aimed to systematically compare brain connectivity and morphological differences in individuals with bipolar disorder and healthy controls. The results showed that patients with bipolar disorder exhibited either increased or decreased functional connectivity in brain networks, accompanied by changes in gray matter volume.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Clinical Neurology