Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 65, Pages 12977-12980Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04647e
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Funding
- Innovative Uses for Advanced Materials in the Modern World (AM2)
- Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
- Research Project Grant from the Royal Society
- MOAC Doctoral Training Centre [EP/F500378/1]
- EPSRC [EP/H005625/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [1091587, EP/H005625/1] Funding Source: researchfish
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Antifreeze (glyco) proteins AF(G) Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.
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