Low-Dose Paclitaxel-Coated Balloons for Femoropopliteal Disease Days of Future Past?

Article Cardiac & Cardiovascular Systems

Low-Dose vs High-Dose Drug-Coated Balloon for Symptomatic Femoropopliteal Artery Disease The PROSPECT MONSTER Study Outcomes

Tatsuya Nakama et al.

Summary: Randomized trials have shown that second-generation low-dose drug-coated balloons (LD-DCBs) and first-generation high-dose drug-coated balloons (HD-DCBs) have comparable outcomes. This study compared the outcomes between LD-DCBs and HD-DCBs in patients with symptomatic femoropopliteal artery disease. The results suggest that LD-DCBs are as effective and safe as HD-DCBs in medically complex populations.

JACC-CARDIOVASCULAR INTERVENTIONS (2023)

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Article Peripheral Vascular Disease

Three-Year Clinical Outcomes Following Implantation of LifeStent Self-Expanding Nitinol Stents in Patients With Femoropopliteal Artery Lesions

Michinao Tan et al.

Summary: This study evaluated midterm clinical outcomes after implantation of LifeStent self-expanding nitinol stents for femoropopliteal lesions, finding that CLTI, CTO, lesion length >= 25 cm, and distal RVD <5 mm were independent risk factors for 3-year restenosis.

ANGIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Improvement of Outcome for Treatment of 'Restenosis-prone' Vascular Lesions? Potential Impact of the Paclitaxel dose on Late Lumen Loss in Porcine Peripheral Arteries

Ole Gemeinhardt et al.

Summary: This study investigated the inhibition of neointimal formation and potential adverse effects after treatment with a novel double-dose drug-coated balloon (DCB) in swine. The results showed that the double-dose DCB treatment was more effective in inhibiting in-stent neointimal formation compared to a market-approved DCB.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Low-Dose vs High-Dose Paclitaxel-Coated Balloons for Femoropopliteal Lesions 2-Year Results From the COMPARE Trial

Sabine Steiner et al.

Summary: This study compares the efficacy and safety of low-dose and high-dose paclitaxel-coated balloons (PCBs) with different coating technologies for femoropopliteal interventions. The 2-year results show no significant difference in treatment effects between the two types of balloons, and both provide sustained treatment benefits.

JACC-CARDIOVASCULAR INTERVENTIONS (2022)

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Review Surgery