Journal
IONICS
Volume -, Issue -, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11581-023-05233-2
Keywords
Azure A; Ascorbic acid; Cyclic voltammetry; Dopamine; Graphite oxide
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In this study, the precise electrochemical determination of dopamine was achieved by modifying a graphite electrode. The modified electrode allowed for the selective determination of dopamine at low concentrations at a lower oxidation potential, and demonstrated advantages such as simple fabrication, low cost, high sensitivity, good selectivity, reproducibility, and stability.
Azure A, a phenothiazine dye was functionalized at graphite oxide through EDC/NHS coupling chemistry. The Azure A-functionalized graphite oxide (AzA-GO) was modified at paraffin impregnated graphite electrode (PIGE) and was used in the precise electrochemical determination of dopamine (DA) in the presence of ascorbic acid (AA). The functionalized AzA-GO was characterized using FTIR, UV-visible spectroscopy, and scanning electron microscopy (SEM). The AzA-GO-modified electrode was characterized by cyclic voltammetry (CV). The electrocatalytic oxidation of DA was found to happen at a low oxidation potential of 0.14 V by the modified electrode. The determination of DA was linear in the concentration range of 8.6 x 10-6 to 9.09 x 10-3 M with the detection limit of 7.2 x 10-7 M. The selective determination of DA in the presence of 100 times higher concentration of AA was achieved by differential pulse voltammetry (DPV). The modified electrode offered a simple, sensitive, and selective determination of low levels of DA at the lower oxidation potential. The proposed sensor has the advantage of easy fabrication, low cost, good sensitivity, selectivity, reproducibility, and stability.
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