Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 62, Pages 12373-12376Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04347f
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Funding
- National Natural Science Foundation of China [21407029, 41401261]
- Pearl River S&T Nova Program of Guangzhou [201506010093]
- Natural Science Foundation of Guangdong Province [2014A030313705]
- Science and Technology Program of Guangzhou [201508020010]
- Key Projects in the National Science & Technology Pillar Program of China [2015BAD06B03]
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A label-free and enzyme-free three-way G-quadruplex junction sensing system for the amplified detection of 17 beta-estradiol has been constructed by the ingenious coupling of split G-quadruplex DNAzyme with toehold-mediated strand displacement. The biosensor is ultrasensitive, enabling the visual detection of 17 beta-estradiol concentrations as low as 1 fM without instrumentation.
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