☆ 4.7 Article

Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for oral delivery: Preparation and in-vitro biopharmaceutical characterization

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Related references

Note: Only part of the references are listed.

Article Pharmacology & Pharmacy

Formation of a Stable Co-Amorphous System for a Brick Dust Molecule by Utilizing Sodium Taurocholate with High Glass Transition Temperature

Shohei Aikawa et al.

Summary: This study aimed to formulate a stable co-amorphous system for brick dust molecules by utilizing sodium taurocholate (NaTC) with a higher glass transition temperature (Tg). Ball milling formed a co-amorphous system for AntiY(5)R and NaTC (AntiY(5)R-NaTC) at various molar ratios. The results showed that AntiY(5)R-NaTC had an 8.5-fold increase in solubility compared to its crystalline form, and the co-amorphous system remained amorphous for 1 month at 25°C and 40°C.

PHARMACEUTICS (2023)

Add to Collection

Article Pharmacology & Pharmacy

Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies

Jakob Tobias Lynnerup et al.

Summary: As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. This study aimed to gain insight into nanoparticle characteristics and performance using an in vitro combined dissolution/permeation setup. The results showed that nanosuspensions exhibited significantly increased dissolution rates and permeation rates compared to the raw APIs.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2023)

Add to Collection

Article Pharmacology & Pharmacy

Poly (amino acid)s as new co-formers in amorphous solid dispersion

Qiang Huang et al.

Summary: The drug-amino acid co-amorphous systems and amorphous solid dispersions (ASDs) are promising methods for poorly water-soluble drugs. Poly (amino acid)-based ASDs with high drug-loading and physical stability were prepared by ball milling poly-L-lysine and polyglutamic acid with mebendazole, tadalafil, and valsartan. The dissolution rate and physical stability of the drugs were improved by the drug-poly (amino acid) ASDs. Salt formation between the drug and poly (amino acid) is not necessary for the formation of promising ASDs.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Add to Collection

Article Pharmacology & Pharmacy

Microdialysis and nanofiltration allow to distinguish molecularly dissolved from colloid-associated drug concentrations during biomimetic dissolution testing of supersaturating formulations

Florentin Lukas Holzem et al.

Summary: This study investigated the dissolution, supersaturation, and precipitation behavior of a poorly water-soluble drug using different sampling methods. The results provided insights into the release and absorption mechanisms of the drug, and demonstrated the importance of microdialysis and nanofiltration approaches for the evaluation of drug formulations.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Add to Collection

Article Pharmacology & Pharmacy

Biopredictive capability assessment of two dissolution/permeation assays, μFLUX™ and PermeaLoop™, using supersaturating formulations of Posaconazole

Florentin Lukas Holzem et al.

Summary: The majority of new drugs have poor water solubility, which requires the development of enabling formulations for sufficient bioavailability upon oral administration. This study compared the biopredictive abilities of two in vitro tools for predicting intestinal supersaturation and systemic absorption of drug formulations. The PermeaLoop™ apparatus showed better predictive ability compared to the mu FLUX™ setup. The study confirms the usefulness of these tools for formulation ranking of weakly basic compounds and supersaturating formulations.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Add to Collection

Article Engineering, Chemical

Sole-amorphous-sugar-based solid dispersion of curcumin and the influence of formulation composition and heat treatment on the dissolution of curcumin

Takanari Sekitoh et al.

Summary: The study utilized an amorphous solid dispersion technique to prepare a solid dispersion of curcumin in a sugar-based matrix. Results showed that the dissolution of curcumin significantly increased when certain sugars were added in specific ratios, and further enhancement was achieved through heating the dispersion near or above the melting points of curcumin.

DRYING TECHNOLOGY (2021)

Add to Collection

Article Chemistry, Medicinal

Do Phospholipids Boost or Attenuate Drug Absorption? In Vitro and In Vivo Evaluation of Mono- and Diacyl Phospholipid-Based Solid Dispersions of Celecoxib

Ann-Christin Jacobsen et al.

Summary: Phospholipids play a crucial role in oral absorption, with systematic studies rare in this area. This study systematically compared two types of phospholipid-based solid dispersions, revealing a negative correlation between phospholipid content and oral absorption. The in vitro permeation screening was able to predict the in vivo performance of the formulations, showcasing its potential as a predictive tool.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Add to Collection

Article Pharmacology & Pharmacy

Physicochemical Properties of Poly-vinyl Polymers and Their Influence on Ketoprofen Amorphous Solid Dispersion Performance: A Polymer Selection Case Study

Emer Browne et al.

PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

Maryam Farzan et al.

PHARMACEUTICS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for Oral Controlled Delivery of Water-Soluble Drugs

Marina Kolbina et al.

AAPS PHARMSCITECH (2019)

Add to Collection

Article Pharmacology & Pharmacy

A dynamic in vitro permeation study on solid mono- and diacyl-phospholipid dispersions of celecoxib

Ann-Christin Jacobsen et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Add to Collection

Article Pharmacology & Pharmacy

Effect of plasticizers on manufacturing ritonavir/copovidone solid dispersions via hot-melt extrusion: Preformulation, physicochemical characterization, and pharmacokinetics in rats

Yanna Zhao et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Add to Collection

Article Pharmacology & Pharmacy

Enhancement of Aqueous Solubility and Dissolution of Celecoxib through Phosphatidylcholine-Based Dispersion Systems Solidified with Adsorbent Carriers

Kanghee Jo et al.

PHARMACEUTICS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015

Jinglu Zhang et al.

MOLECULES (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Towards controlling the crystallisation behaviour of fenofibrate melt: triggers of crystallisation and polymorphic transformation

Pratchaya Tipduangta et al.

RSC ADVANCES (2018)

Add to Collection

Article Pharmacology & Pharmacy

Saturated phosphatidylcholine as matrix former for oral extended release dosage forms

Marina Kolbina et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Add to Collection

Article Pharmacology & Pharmacy

Dynamic dissolution-/permeation-testing of nano- and microparticle formulations of fenofibrate

Daniel Sironi et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Add to Collection

Article Medicine, Research & Experimental

Impact of Polymer Type and Relative Humidity on the Long-Term Physical Stability of Amorphous Solid Dispersions

Kristin Lehmkemper et al.

MOLECULAR PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Molecular dynamics of amorphous pharmaceutical fenofibrate studied by broadband dielectric spectroscopy

U. Sailaja et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2016)

Add to Collection

Review Pharmacology & Pharmacy

Phospholipid-based solid drug formulations for oral bioavailability enhancement: A meta-analysis

Sophia Yui Kau Fong et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Add to Collection

Article Pharmacology & Pharmacy

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

Bart Hens et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Add to Collection

Article Pharmacology & Pharmacy

Solubility enhancement of BCS Class II drug by solid phospholipid dispersions: Spray drying versus freeze-drying

Sophia Yui Kau Fong et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Add to Collection

Article Chemistry, Medicinal

What Is the Mechanism Behind Increased Permeation Rate of a Poorly Soluble Drug from Aqueous Dispersions of an Amorphous Solid Dispersion?

Kerstin J. Frank et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

Add to Collection

Article Pharmacology & Pharmacy

Single step bottom-up process to generate solid phospholipid nano-particles

Ulla Brinkmann-Trettenes et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2014)

Add to Collection

Article Chemistry, Multidisciplinary

Correlation of Inhibitory Effects of Polymers on Indomethacin Precipitation in Solution and Amorphous Solid Crystallization Based on Molecular Interaction

Harsh Chauhan et al.

PHARMACEUTICAL RESEARCH (2014)

Add to Collection

Article Pharmacology & Pharmacy

Amino acids as co-amorphous stabilizers for poorly water soluble drugs - Part 1: Preparation, stability and dissolution enhancement

Korbinian Lobmann et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

Add to Collection

Article Pharmacology & Pharmacy

Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: True supersaturation vs. apparent solubility enhancement

Kerstin J. Frank et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

Add to Collection

Article Chemistry, Medicinal

In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hot-melt extrusion

Haibing He et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2010)

Add to Collection

Article Pharmacology & Pharmacy

Formation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media

Ingunn Tho et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

Add to Collection

Article Chemistry, Analytical

In situ formation of nanoparticles upon dispersion of melt extrudate formulations in aqueous medium assessed by asymmetrical flow field-flow fractionation

Johanna Kanzer et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2010)

Add to Collection

Article Chemistry, Medicinal

Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations

Hector R. Guzman et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

Add to Collection

Article Pharmacology & Pharmacy

A new fenofibrate formulation: Results of six single-dose, clinical studies of bioavailability under fed and fasting conditions

PH Guivarc'h et al.

CLINICAL THERAPEUTICS (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.