Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 66, Pages 13113-13116Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04968g
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Funding
- National Natural Science Foundation of China [81273471, 21302016, 81303208]
- Fundamental Research Funds for the Central Universities [2015SCU04A13]
- Distinguished Young Scholars of Sichuan University [2015SCU04A13]
- Foundation for the Author of National Excellent Doctoral Dissertation of China [201487]
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The enantioselective preparation of pharmacologically interesting chroman-fused spirooxindole derivatives is described based on an organocatalytic multicomponent cascade reaction. The compounds synthesized using this method potently inhibited the proliferation of various cancer cell lines. The most potent compound (7e) induced caspase-independent apoptosis and cell cycle arrest in MCF-7 breast cancer cells by interfering with the p53-MDM2 interaction and downstream pathways.
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