Related references
Note: Only part of the references are listed.
Article
Pharmacology & Pharmacy
Farzad Rahmani et al.
Summary: Hydrogels have opened new prospects for drug delivery. Thermo-sensitive hydrogels, especially those based on PLGA, have shown great potential in providing effective and controllable release of therapeutic agents in response to temperature changes. This review focuses on the recent progress and applications of thermo-sensitive and biodegradable PLGA-based hydrogels for smart drug delivery to different organs. Future perspectives and challenges of thermo-sensitive PLGA-based hydrogels are also briefly discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
David F. Williams
Summary: Biocompatibility concerns the interactions between biomaterials and human patients, and involves various disciplines such as materials science, engineering, chemistry, and biology. The mechanisms of biocompatibility are complex due to the plasticity of pathways and the influence of genetic, epigenetic, viral, mechanical, physical, and pharmacological factors. Successful outcomes can be achieved through classic linear pathways, but alternative pathways driven by biological plasticity often result in unsuccessful outcomes despite the use of identical technologies.
Review
Pathology
Mara H. Sherman et al.
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a diverse stromal microenvironment that plays a significant role in disease biology and treatment resistance. Recent advancements in imaging, single-cell analytics, and disease modeling have provided insights into the complexity of PDAC tumors. Understanding the functional and spatial dependencies between cancer cells and extracellular matrix components can reveal therapeutic vulnerabilities.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2023)
Review
Oncology
Naotake Funamizu et al.
Summary: This review summarizes the current evidence for the role of microRNAs (miRNAs) in the mechanism of chemoresistance in pancreatic cancer. Pancreatic cancer has a poor prognosis due to its late discovery, aggressive nature, and chemoresistance. Aberrant miRNAs have been found to induce chemoresistance in pancreatic cancer, but the exact molecular mechanisms are still unclear. Novel biomarkers and therapeutic strategies for chemoresistance are urgently needed to improve patient outcomes.
Review
Biochemistry & Molecular Biology
Aydin Bordbar-Khiabani et al.
Summary: Smart hydrogels, a type of material that can respond to stimuli and adapt their responses based on external cues, have emerged as a promising research frontier in the field of biomedical engineering. With their high stability, physicochemical properties, and biocompatibility, smart hydrogels have the potential to be used in drug delivery systems. By changing their properties under external stimuli such as pH, temperature, electrical and magnetic fields, light, and biomolecules concentration, smart hydrogels can achieve controlled release of loaded drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sharda Pandit et al.
Summary: The method of creating materials-free intratumoral drug depots through Tissue-Reactive Anchoring Pharmaceuticals (TRAPs) has the potential to achieve sustained drug delivery in desmoplastic tumor tissues, providing a promising approach for the treatment of localized diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Qinjun Chen et al.
Summary: A versatile drug delivery system is developed to target the complex tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC). By sensing the gradient pH variation and reversing surface charges, the system achieves higher drug penetration. It releases gemcitabine and a STAT3 inhibitor to inhibit tumor immunosuppression and relieve drug resistance. The synergetic therapeutic efficacy of the system provides more opportunities for clinical treatment of PDAC.
Review
Oncology
Nicholas A. Ullman et al.
Summary: This article summarizes the mechanisms of immunosuppression within the PDAC tumor microenvironment and provides an up-to-date review of completed and ongoing clinical trials using various immunotherapy strategies.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Mirela Kremenovic et al.
Summary: In this study, a novel BCG lysate was developed and formulated into a thermosensitive hydrogel. The BCG lysate exhibited enhanced antitumor efficacy and promoted a proinflammatory tumor microenvironment in vivo. The underlying mechanisms of BCG lysate-mediated tumor immunity relied on macrophages (M phi) and dendritic cells (DCs). The BCG hydrogel treatment induced systemic immunity, suppressed lung metastases, and improved survival in melanoma-bearing mice. Furthermore, BCG hydrogel treatment enhanced antigen processing and presentation, and increased the frequency of melanoma-reactive CD8(+) T cells. In human melanoma patients, intralesional-BCG treatment was associated with enhanced M1 M phi, mature DCs, antigen processing and presentation, and increased patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Chao Gao et al.
Summary: In this study, a novel hydrogel was developed for pancreatic cancer immunotherapy. The hydrogel can reshape the tumor microenvironment, increase the number of M1 phenotype macrophages, and control tumor growth.
Review
Gastroenterology & Hepatology
Kazuyuki Matsumoto et al.
Summary: Endoscopic ultrasound (EUS)-guided ablation therapy has been reported as a less invasive treatment for pancreatic neoplasms, with injective ablation and radiofrequency ablation being the most commonly used techniques. Studies have shown that EUS-guided ethanol ablation and EUS-RFA are effective treatments for potentially malignant solid neoplasms, with high complete response rates. EUS-RFA appears to be superior to EUS-EA in terms of complete tumor ablation. The effectiveness of EUS-guided injection ablation therapy for pancreatic cystic neoplasms has also been investigated, with alcohol-free chemotherapeutic agent ablation showing promise.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Syed Mohsin Saghir et al.
Summary: EUS-guided ethanol with paclitaxel (EUS EP) ablation shows comparable efficacy and safety to EUS-guided ethanol ablation (EUS E) for the management of pancreatic lesions. Further research is needed to validate these findings.
ENDOSCOPIC ULTRASOUND
(2022)
Review
Engineering, Biomedical
Bowen Tan et al.
Summary: Water-based therapy has emerged as a promising option for cancer treatment due to its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli-sensitivity. It not only has good malleability to reach difficult-to-access areas, but also can serve as a carrier for tumor treatment agents and a scaffold for tissue repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Oncology
Henriette Berg Andersen et al.
Summary: PDAC is a deadly cancer with limited therapeutic options, characterized by an acidic tumor microenvironment and metabolic rewiring. Metabolic crosstalk with nonmalignant cells and resistance to conventional treatments contribute to treatment failure. Increasing research focuses on targeting pro-tumorigenic metabolic pathways for potential therapeutic opportunities.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Weipeng Wei et al.
Summary: The study demonstrated that the RADA16-I-EM in situ hydrogels significantly reduced the toxicity of EM to normal cells and inhibited the survival of tumor cells. The uptake of EM by cells from the hydrogels increased significantly, inducing cell apoptosis, arresting the cell cycle, and reducing cell migration, invasion, and colony-forming ability. The RADA16-I-EM in situ hydrogel effectively inhibited tumor growth and decreased the toxic effects of EM on normal tissues in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ahmed M. Shabana et al.
Summary: The translated system enhances the delivery of gemcitabine and paclitaxel to pancreatic cancer, effectively killing cancer cells and inhibiting tumor growth with sustained release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Oncology
Jinxin Tao et al.
Summary: Pancreatic cancer, characterized by late diagnosis, early metastasis, and poor prognosis, exhibits high lethality globally. The hypoxic microenvironment in pancreatic cancer has extensive effects on biological behaviors and malignant phenotypes, leading to aggressive progression and therapeutic resistance. Innovative therapies targeting the tumor hypoxic microenvironment show great potential in overcoming treatment resistance and enhancing antitumor efficacy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Michael J. Mitchell et al.
Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Yuyi Qian et al.
Summary: Transarterial radioembolization (TARE) is an effective treatment for intermediate-stage hepatocellular carcinoma (HCC). A highly tumor-specific I-131-TARE agent with long-time retention has been developed using tyrosine-modified poly(vinyl alcohol) drug-eluting microbeads (Tyr-PVA-DEBs). This agent allows localized delivery of high-radiation doses to tumors following a single low-dose injection, showing potential for clinical application in treating HCC.
Article
Biophysics
Deepak Kukkar et al.
Summary: Nanomaterial-antibody conjugates offer significant advantages in cancer theranostics, improving drug specificity and distribution in targeted tissues while reducing side effects. This comprehensive review discusses recent advances and future directions in the application of nanomaterial-antibody conjugates for cancer treatment.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Materials Science, Biomaterials
Amir Mellati et al.
Summary: Hydrogels have gained attention in biomedical and pharmaceutical applications due to their biomimetic structure and excellent properties, with injectable hydrogels being particularly popular for their comfortable and convenient use. By incorporating nanofillers into the polymeric matrix, injectable nanocomposite hydrogels with combined properties can be engineered.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Zehao Jing et al.
Summary: The use of 3D-printed titanium alloy implants loaded with cisplatin within a hydrogel is a safe and effective treatment option for osteosarcoma-caused bone defects, providing both anti-tumor and bone repair functions. In vitro experiments confirmed the anti-tumor effects of the implants, while in vivo studies demonstrated long-term bone growth and osseointegration of the implants.
BIOACTIVE MATERIALS
(2021)
Review
Oncology
Florentine E. F. Timmer et al.
Summary: PDAC is an aggressive neoplasm with poor prognosis, and LAPC is unresectable at this stage. Locoregional percutaneous interventional techniques show promise in prolonging survival and reducing tumor size, with potential immunomodulatory capacities. Combining these techniques with immunotherapy may lead to a durable anti-tumor effect, currently under investigation in ongoing clinical trials.
CURRENT ONCOLOGY REPORTS
(2021)
Review
Medicine, General & Internal
Wungki Park et al.
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Hongqiao Cai et al.
Summary: The combination of gemcitabine-loaded PLGA nanoparticles with a macrophage membrane coating showed promising results in reducing drug toxicity, improving tumor accumulation, and inhibiting pancreatic cancer cell proliferation through targeting signaling pathways. This approach provides potential synergistic anti-tumor efficacy for treating pancreatic cancer.
MOLECULAR PHARMACEUTICS
(2021)
Review
Gastroenterology & Hepatology
Mihai Rimbas et al.
DIGESTIVE ENDOSCOPY
(2020)
Review
Pharmacology & Pharmacy
Aubrey L. Miller et al.
PHARMACOLOGICAL RESEARCH
(2020)
Review
Chemistry, Physical
Adam Chyzy et al.
Article
Chemistry, Medicinal
Md. Habban Akhter et al.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Article
Medicine, General & Internal
Jonathan D Mizrahi et al.
Article
Oncology
Stijn van Roessel et al.
Article
Surgery
Georgios Gemenetzis et al.
Article
Gastroenterology & Hepatology
Albrecht Neesse et al.
Article
Chemistry, Physical
Kun Shi et al.
Article
Pharmacology & Pharmacy
Pui Shan Chan et al.
Article
Chemistry, Multidisciplinary
Mingtan Tang et al.
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Medicine, Research & Experimental
Xiaobin Chen et al.
Article
Biotechnology & Applied Microbiology
Md. Habban Akhter et al.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2018)
Article
Oncology
Reham Abdel-Wahab et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2018)
Article
Gastroenterology & Hepatology
Titus F. M. Wijnands et al.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2018)
Article
Gastroenterology & Hepatology
Michael J. Levy et al.
GASTROINTESTINAL ENDOSCOPY
(2017)
Article
Chemistry, Multidisciplinary
John Garner et al.
JOURNAL OF CONTROLLED RELEASE
(2017)
Review
Biochemistry & Molecular Biology
Chen Liang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2017)
Review
Gastroenterology & Hepatology
Sundeep Lakhtakia et al.
DIGESTIVE ENDOSCOPY
(2017)
Article
Chemistry, Multidisciplinary
Hongtao Xu et al.
PHARMACEUTICAL RESEARCH
(2016)
Article
Oncology
JM Reid et al.
JOURNAL OF CLINICAL ONCOLOGY
(2004)
