☆ 4.7 Review

Liver Cell Type-Specific Targeting by Nanoformulations for Therapeutic Applications

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Medicine, Research & Experimental

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells

Camille-Charlotte Balanca et al.

Summary: Tumor antigen-specific CD4 T cells exhibit exhaustion in patients with head and neck, cervical, and ovarian cancer, characterized by high PD-1 and CD39 expression and low cytokine secretion despite functional presence. Terminal exhaustion of CD4 T cells is observed regardless of TIM-3 expression, suggesting divergence from CD8 T cell exhaustion. PD-1 blockade enhances CD4 T cell activation and promotes dendritic cell maturation, leading to improved tumor-specific CD8 T cell proliferation.

JCI INSIGHT (2021)

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Article Immunology

Hepatitis B Vaccines

Jade Pattyn et al.

Summary: The coverage of hepatitis B vaccines is increasing, and the effective implementation of vaccination programs has significantly reduced the morbidity and mortality related to hepatitis B.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal

Macrophage Activation Markers, Soluble CD163 and Mannose Receptor, in Liver Fibrosis

Rasmus Hvidbjerg Gantzel et al.

Summary: Macrophages are crucial components of the human immune system, playing important roles in immune regulation and tissue repair. In liver diseases, they are involved in inflammation and fibrosis, with soluble CD163 and soluble mannose receptor potentially serving as promising biomarkers for assessing disease severity and predicting outcomes.

FRONTIERS IN MEDICINE (2021)

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Review Gastroenterology & Hepatology

Recent updates on the management of autoimmune hepatitis

Atsumasa Komori

Summary: Autoimmune hepatitis is a chronic liver disease characterized by immunoinflammatory processes, diagnosed based on serum biochemistry and liver histology. Treatment typically involves corticosteroids and azathioprine, with second-line therapies for incomplete response or intolerance. Personalized medicine should be considered for improved quality of life in AIH patients.

CLINICAL AND MOLECULAR HEPATOLOGY (2021)

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Article Engineering, Biomedical

Engineered therapeutic nanovaccine against chronic hepatitis B virus infection

Dongdong Qiao et al.

Summary: Nanovaccines prepared using flash nanocomplexation technology enhance the uptake of antigens and adjuvants by cells, promote the maturation and activation of dendritic cells, and exhibit excellent lymph nodes targeting ability. Co-administered nanovaccines can break immune tolerance, restore HBV-specific immune responses, and achieve high rates of seroclearance and seroconversion in a mouse model of CHB. The vaccines also induce long-term immune memory to protect against HBV reinfection.

BIOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

Controlled Drug Delivery Systems: Current Status and Future Directions

Shivakalyani Adepu et al.

Summary: The paper discusses the evolution of drug delivery systems, the limitations of conventional drug delivery, and the details of controlled drug delivery systems, including design considerations, classifications, and recent research findings on nano-drug delivery, targeted drug delivery, and smart drug delivery using intelligent biomaterials. The challenges and future directions in controlled drug delivery are also addressed in the conclusion.

MOLECULES (2021)

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Article Chemistry, Multidisciplinary

Immunosuppressive Nanoparticles for Management of Immune-Related Adverse Events in Liver

Shufang Shen et al.

Summary: The study developed immunosuppressive nanoparticles by coating PD-L1 overexpressed MSCs plasma membrane on PLGA nanoparticles, aiming to reduce irAEs caused by immune checkpoint inhibitors. These nanoparticles showed potential in rescuing hepatitis in a clinically relevant mouse model without affecting the efficiency of ICB therapy in inhibiting tumor growth.

ACS NANO (2021)

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Article Biotechnology & Applied Microbiology

Chemo-photodynamic therapy with light-triggered disassembly of theranostic nanoplatform in combination with checkpoint blockade for immunotherapy of hepatocellular carcinoma

Jianjun Xu et al.

Summary: A light-triggered nanoplatform co-loaded with a photosensitizer and paclitaxel was developed for synergistic chemo-photodynamic therapy in hepatocellular carcinoma. The nanoplatform specifically accumulated at the tumor site through active targeting and facilitated image-guided PDT for tumor ablation. This combined therapy approach showed enhanced anti-tumor effects and potential for inhibiting tumor relapse and metastasis.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Physiology

The Scavenger Function of Liver Sinusoidal Endothelial Cells in Health and Disease

Sabin Bhandari et al.

Summary: This review outlines the blood clearance function of liver sinusoidal endothelial cells (LSECs) in both health and disease, highlighting their high-affinity receptors and intracellular vesicle transport system. It also discusses the similarities and differences between LSECs and specialized scavenger endothelial cells (SECs) in various vascular beds and vertebrate classes. The activity of LSECs and other SECs helps to maintain blood and tissue homeostasis by efficiently clearing large molecules and nanoparticles, but this process may also result in unwanted uptake of nanomedicines and biologics.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

The transcatheter arterial chemoembolization combined with targeted nanoparticle delivering sorafenib system for the treatment of microvascular invasion of hepatocellular carcinoma

Dongna Su

Summary: This study investigated the value of TACE combined with a targeted nanoparticle delivery system for treating HCC with microvascular invasion. The experimental group showed slightly better treatment outcomes and a lower incidence of adverse reactions compared to the control group.

BIOENGINEERED (2021)

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Article Biochemistry & Molecular Biology

Preferential Expression of Programmed Death Ligand 1 Protein in Tumor-Associated Macrophages and Its Potential Role in Immunotherapy for Hepatocellular Carcinoma

Dong-Jun Park et al.

Summary: The study found that tumor-associated macrophages (TAMs) in the tumor microenvironment of hepatocellular carcinoma (HCC) express PD-L1, and ICI treatment can reactivate CD8(+) T cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma

Mara Kloehn et al.

Summary: Hepatitis E virus infections are a leading cause of viral hepatitis in humans, contributing to around 3.3 million symptomatic cases and nearly 44,000 deaths annually. Recent findings suggest a potential link between chronic HEV infections and hepatocarcinogenesis, despite the rare documentation of HEV-induced hepatocellular carcinoma. The expanding clinical spectrum of HEV and the increasing evidence of chronic infections raise questions about the connection between HEV and HCC.

CANCERS (2021)

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Article Multidisciplinary Sciences

Stabilin receptors clear LPS and control systemic inflammation

Fatima Cabral et al.

Summary: The study revealed that Stab1 primarily facilitates the proactive clearance of LPS and limits TLR4-mediated inflammation, with TLR4 and Stab1 functionally opposing each other as LPS receptors. It suggests that endotoxemia can be controlled by optimizing LPS clearance by Stab1.

ISCIENCE (2021)

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Review Biochemistry & Molecular Biology

Liver sinusoidal endothelial cells are implicated in multiple fibrotic mechanisms

Heming Ma et al.

Summary: Chronic liver diseases are caused by liver injury, with fibrosis being a dynamic process involving various molecular and cellular mechanisms. Liver sinusoidal endothelial cells (LSECs) play a crucial role in the pathogenesis of liver diseases and fibrosis. Various cytokines, pathways, and factors are involved in the development of LSEC-mediated liver fibrosis.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Chemistry, Multidisciplinary

High-density lipoprotein modulates tumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma

Junyang Wang et al.

Summary: This study suggests that synthetic high-density lipoproteins (sHDLs) can deliver drugs selectively to tumor cells, improving prognosis in patients with hepatocellular carcinoma. The findings show that VG-sHDLs induce the release of various molecules and cytokines from HCC cells, promoting differentiation into activated macrophages and enhancing immune cell activity, leading to improved tumor eradication.

NANO TODAY (2021)

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Review Gastroenterology & Hepatology

From hepatitis A to E: A critical review of viral hepatitis

Daniel Castaneda et al.

Summary: Viral infections affecting the liver have significant impact on human health, leading to high morbidity and mortality rates. Understanding hepatitis A, B, C, D, and E is crucial for healthcare professionals to provide proper care for patients. Scientific advancements have made controlling and curing these infections a possibility, with a focus on preventive medicine through vaccination.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Review Medicine, General & Internal

Liver metastases

Diamantis I. Tsilimigras et al.

Summary: Liver metastases are commonly detected in various malignancies, with interactions between tumor cells and the microenvironment playing a crucial role. Treatment options include surgical resection, systemic therapies, and newer biologic agents, with the incorporation of genetic tests providing more accurate information for clinical decision-making.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Multidisciplinary Sciences

Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders

Xin Zhao et al.

Summary: A newly developed polymer nanocomplex has been shown to effectively help manage diabetes, nonalcoholic fatty liver disease, and obesity by absorbing all sugars and preventing their absorption in the gut, leading to improved postprandial blood glucose reduction and reduced hepatic lipogenesis in various mouse models. It offers benefits for prediabetic, diabetic, overweight, and even healthy individuals in managing sugar intake.

SCIENCE ADVANCES (2021)

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Review Cell Biology

CD4+ T Cells in Chronic Hepatitis B and T Cell-Directed Immunotherapy

Sonja I. Buschow et al.

Summary: Research on the impaired T cell responses in chronic hepatitis B patients has mainly focused on CD8(+) T cells, while CD4(+) T cells are crucial in the development of long-lasting effector CD8(+) T cells. This review discusses the importance of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Macrophage Polarization States in the Tumor Microenvironment

Ava J. Boutilier et al.

Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Roles of CCL2-CCR2 Axis in the Tumor Microenvironment

Suguru Kadomoto et al.

Summary: Chemokines are a family of cytokines that play important roles in cancer progression. The CCL2-CCR2 axis is a major chemokine signaling pathway that impacts tumor progression significantly.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Manipulation of TAMs functions to facilitate the immune therapy effects of immune checkpoint antibodies

Yang Liu et al.

Summary: Manipulation of tumor-associated macrophages (TAMs) has been identified as a key factor in improving immunotherapies, with inhibition of the NF-kappa B pathway potentially impacting both PD-1/PD-L1 and NF-kappa B pathways simultaneously. Co-loading PD-1 antibody and NF-kappa B pathway inhibitor in nanocarriers has shown promising results in enhancing the efficacy of immunotherapies.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Gastroenterology & Hepatology

Metabolic disorders and the risk of cholangiocarcinoma

Michele Ghidini et al.

Summary: Metabolic disease is associated with a higher risk of intrahepatic CCA compared to its extrahepatic or hilar counterpart. As rates of obesity and metabolic syndrome increase, particularly in the West, it is conceivable that the incidence of CCA will also rise in the next years.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Microbiology

Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin

Hans J. Netter et al.

Summary: Hepatitis delta virus (HDV) is a human pathogen that relies on hepatitis B virus (HBV) for packaging, release, and transmission. Replication of HDV occurs in the nucleus and is mediated by host enzymes.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Physiology

The wHole Story About Fenestrations in LSEC

Karolina Szafranska et al.

Summary: The porosity of liver sinusoidal endothelial cells (LSEC) plays a crucial role in the bidirectional passive transport of lipoproteins, drugs, and solutes between liver capillaries and parenchyma. Various factors, including aging and liver disorders, can severely reduce LSEC porosity and affect their filtration properties. Recent research suggests that certain medications may have a beneficial effect on LSEC re-fenestration in aging populations, highlighting the importance of understanding and regulating LSEC porosity for overall liver health.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Immunology

Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment

Zicong He et al.

Summary: TAMs are crucial immune cells in tumors, and their functional transformation from M1 to M2 as tumors progress plays a key role in immunosuppression and tumor promotion processes. Understanding the mechanism of TAM functional transformation in the hypoxic environment is essential for developing novel tumor immunotherapeutic strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Interferon and Hepatitis B: Current and Future Perspectives

Jianyu Ye et al.

Summary: IFN therapy has unique advantages in treating chronic hepatitis B, but its efficacy is limited and side effects are common. To seek a cure for HBV, improving IFN therapy and combining it with other antiviral agents may be considered.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Isak W. Tengesdal et al.

Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles

Petr O. Ilyinskii et al.

Summary: ImmTOR, a biodegradable nanoparticle encapsulating rapamycin, induces a durable tolerogenic immune response to co-administered biologics and gene therapy vectors. Studies show that ImmTOR selectively distributes to the spleen and liver, inducing tolerogenic immune responses. The liver cells actively take up ImmTOR particles, downregulating MHC-II and co-stimulatory molecules and upregulating PD-L1, contributing to the tolerogenic properties of ImmTOR treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Cholangiocarcinoma

Paul J. Brindley et al.

Summary: Cholangiocarcinoma is a highly lethal adenocarcinoma of the hepatobiliary system that can be associated with liver fluke infection but often has no identifiable cause. This Primer reviews the epidemiology, pathophysiological mechanisms, diagnosis and management of cholangiocarcinoma, and highlights the patient experience and future directions.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Review Oncology

Tumor-Associated Neutrophils in Hepatocellular Carcinoma Pathogenesis, Prognosis, and Therapy

Konstantinos Arvanitakis et al.

Summary: Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer worldwide, and inflammation has been identified as a key factor in cancer development, driving the involvement of neutrophils in disease progression. While high infiltration with tumor-associated neutrophils (TANs) has been correlated with increased tumor growth and poor prognosis in most solid human tumors, under certain conditions, neutrophils may also exhibit cytotoxic and inhibitory activity towards tumor cells. The role of tumor-associated neutrophils (TANs) in HCC development remains ambiguous, with N1 TANs showing anti-tumorigenic activity and N2 TANs being associated with increased growth, invasiveness, and metastasis in HCC.

CANCERS (2021)

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Review Cell Biology

Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy

Tsai-Mu Cheng et al.

Summary: Integrin alpha v beta 3 plays a crucial role in cancer cell proliferation and metastasis, with its ligands and crosstalk with other signaling pathways regulating cancer growth. Inhibition of signals related to integrin alpha v beta 3 has shown promise as a target for cancer therapies. Nanotechnologies, such as the use of nanomaterial carriers, are being increasingly explored for their potential potentiation in cancer treatments targeting integrin alpha v beta 3.

CELLS (2021)

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Review Oncology

HBV Reactivation During the Treatment of Non-Hodgkin Lymphoma and Management Strategies

Xing Cao et al.

Summary: HBV-R is a common and dangerous complication during the treatment of NHL patients, potentially leading to increased morbidity and mortality. Immunosuppressive therapies increase the risk of HBV-R, highlighting the importance of enhanced screening and monitoring measures.

FRONTIERS IN ONCOLOGY (2021)

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Article Medicine, Research & Experimental

Site-specific glycoproteomic analysis revealing increased core-fucosylation on FOLR1 enhances folate uptake capacity of HCC cells to promote EMT

Li Jia et al.

Summary: The study identified core-fucosylation as a key glycosylation modification linked to the promotion of EMT in HCC cells, with FOLR1 as a potential target for therapeutic interventions. The up-regulation of FUT8 was found to drive EMT induced by HGF/TGF-beta 1, highlighting the importance of glycosylation in cancer progression. Further experiments demonstrated that core-fucosylation on FOLR1 enhanced folate uptake, ultimately promoting EMT in HCC cells.

THERANOSTICS (2021)

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Article Nanoscience & Nanotechnology

CD147 Monoclonal Antibody Targeted Reduction-Responsive Camptothecin Polyphosphoester Nanomedicine for Drug Delivery in Hepatocellular Carcinoma Cells

Hongrui Tian et al.

Summary: In this study, an antibody-conjugated polymeric prodrug nanoparticle was developed for targeted delivery of camptothecin to liver tumor cells. The nanoparticles showed higher uptake and accumulation in HepG2 cells due to specific binding of CD147 antibody to CD147 protein overexpressed in the cells. This method provides a precise targeting function to liver cancer cells, enhancing the effectiveness of anti-cancer therapies.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A dual-functional nanovehicle with fluorescent tracking and its targeted killing effects on hepatocellular carcinoma cells

Xiaojie Zhang et al.

Summary: The study introduces a novel dual-functional nanovehicle for targeted cancer therapy, showing enhanced cytotoxicity and apoptosis-inducing activity in tumor cells compared to normal cells, as well as low cytotoxicity, pH-dependent controlled release, and the ability to achieve targeted imaging and delivery in cancer chemotherapies.

RSC ADVANCES (2021)

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Article Nanoscience & Nanotechnology

Oxaliplatin and Gedatolisib (PKI-587) Co-Loaded Hollow Polydopamine Nano-Shells with Simultaneous Upstream and Downstream Action to Re-Sensitize Drugs-Resistant Hepatocellular Carcinoma to Chemotherapy

Yin-Ci Zhang et al.

Summary: A nano-delivery system containing OXA and PKI-587 was developed to combat drug resistance in HCC chemotherapy. The combination therapy effectively inhibited the proliferation of OXA-resistant H-R cells, with significant improvement in cell viability compared to single-agent OXA treatment.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Therapeutic applications of AS1411 aptamer, an update review

Rezvan Yazdian-Robati et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Challenges in liver cancer and possible treatment approaches

David Anwanwan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Review Oncology

Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Xu Lei et al.

CANCER LETTERS (2020)

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Review Pharmacology & Pharmacy

Exploring Dysregulated Signaling Pathways in Cancer

Sabah Nisar et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Medicine, Research & Experimental

Mechanisms of liver fibrosis and its role in liver cancer

Debanjan Dhar et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor

Bao-Hua Li et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Gastroenterology & Hepatology

Antitumor immunity of low-dose cyclophosphamide: changes in T cells and cytokines TGF-beta and IL-10 in mice with colon-cancer liver metastasis

Xiao-Ming Huang et al.

GASTROENTEROLOGY REPORT (2020)

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Article Medicine, Research & Experimental

Interferon-Free Hepatitis C Virus Therapy

Jean-Michel Pawlotsky

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

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Review Immunology

Macrophage Phenotype and Function in Liver Disorder

Lang Dou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

Francesca Zanieri et al.

CELLS (2020)

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Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Gastroenterology & Hepatology

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

Qing Ye et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Review Oncology

Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook

Josep Garcia et al.

CANCER TREATMENT REVIEWS (2020)

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Article Biotechnology & Applied Microbiology

Homotypic cell membrane-cloaked biomimetic nanocarrier for the accurate photothermal-chemotherapy treatment of recurrent hepatocellular carcinoma

Yingxue Sun et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Nanoparticle Delivery of MnO2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma

Chih-Chun Chang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Pharmacology & Pharmacy

Hepatitis B virus biology and life cycle

Senko Tsukuda et al.

ANTIVIRAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy

Xiao Liu et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2020)

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Review Cell Biology

Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers

Leonard Kaps et al.

CELLS (2020)

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Review Cell Biology

In Search of Zonation Markers to Identify Liver Functional Disorders

Qiuyuan Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Cell Biology

Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages

Sabin Bhandari et al.

BMC MOLECULAR AND CELL BIOLOGY (2020)

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Article Gastroenterology & Hepatology

EASL recommendations on treatment of hepatitis C: Final update of the series

Jean-Michel Pawlotsky et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Engineering, Biomedical

Rational design and latest advances of codelivery systems for cancer therapy

Q. Y. Meng et al.

MATERIALS TODAY BIO (2020)

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Article Medicine, Research & Experimental

Coating biomimetic nanoparticles with chimeric antigen receptor T cell-membrane provides high specificity for hepatocellular carcinoma photothermal therapy treatment

Weijie Ma et al.

THERANOSTICS (2020)

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Article Nanoscience & Nanotechnology

In vivo Targeting of Liver Cancer with Tissue- and Nuclei-Specific Mesoporous Silica Nanoparticle-Based Nanocarriers in mice

Ziqiang Ding et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Chemistry, Medicinal

Virological Basis for the Cure of Chronic Hepatitis B

Jin Hu et al.

ACS INFECTIOUS DISEASES (2019)

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Review Biochemistry & Molecular Biology

Hepatotoxicity induced by immune checkpoint inhibitors: a comprehensive review including current and alternative management strategies

Joseph J. Jennings et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2019)

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Article Cell Biology

Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma

Makiko Adachi et al.

HISTOPATHOLOGY (2019)

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Article Engineering, Biomedical

Doxorubicin-loaded Fe3O4-ZIF-8 nano-composites for hepatocellular carcinoma therapy

Chong Cheng et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2019)

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Review Biochemistry & Molecular Biology

Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

Justine Habault et al.

MOLECULES (2019)

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Article Chemistry, Multidisciplinary

Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model

Qi Liu et al.

ACS NANO (2019)

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Article Nanoscience & Nanotechnology

In vitro and in vivo mechanism of hepatocellular carcinoma inhibition by β-TCP nanoparticles

Langlang Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Pharmacology & Pharmacy

Natural biodegradable polymers based nano-formulations for drug delivery: A review

Archana George et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Review Gastroenterology & Hepatology

From NASH to HCC: current concepts and future challenges

Quentin M. Anstee et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Respiratory System

The Role of the Thymus in the Immune Response

Puspa Thapa et al.

THORACIC SURGERY CLINICS (2019)

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Article Multidisciplinary Sciences

Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Mengying Hu et al.

NATURE COMMUNICATIONS (2019)

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Article Biotechnology & Applied Microbiology

Gold nano-particles (AuNPs) carrying miR-326 targets PDK1/AKT/c-myc axis in hepatocellular carcinoma

Yichao Mo et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Review Immunology

Ontogeny of Tumor-Associated Macrophages

Marie Laviron et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Oncology

IL-10 promoter hypomethylation is associated with increased IL-10 expression and poor survival in hepatocellular carcinoma

Xianjing Zhang et al.

TRANSLATIONAL CANCER RESEARCH (2019)

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Article Pharmacology & Pharmacy

Glycyrrhetinic acid-modified graphene oxide mediated siRNA delivery for enhanced liver-cancer targeting therapy

Ying Qu et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Pathology

Peritumoural CCL1 and CCL22 expressing cells in hepatocellular carcinomas shape the tumour immune infiltrate

Gabriela M. Wiedemann et al.

PATHOLOGY (2019)

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Review Immunology

Liver-Mediated Adaptive Immune Tolerance

Meijuan Zheng et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis-Updated 2019

Bedair Dewidar et al.

CELLS (2019)

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Article Nanoscience & Nanotechnology

Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo

Duoduo Zhang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Article Cell Biology

Chemically modified liposomes carrying TRAIL target activated hepatic stellate cells and ameliorate hepatic fibrosis in vitro and in vivo

Qinghua Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Gastroenterology & Hepatology

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients

Barbara Testoni et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Oncology

CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line

Ryoma Asai et al.

CANCER MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model

Martina Bruna Violatto et al.

ACS NANO (2019)

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Article Medicine, Research & Experimental

Theranostic Nanodots with Aggregation-Induced Emission Characteristic for Targeted and Image-Guided Photodynamic Therapy of Hepatocellular Carcinoma

Yang Gao et al.

THERANOSTICS (2019)

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Article Oncology

Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma

Meiling Zhou et al.

JOURNAL OF CANCER (2019)

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Article Chemistry, Multidisciplinary

Selective targeting of tumor cells and tumor associated macrophages separately by twin-like core-shell nanoparticles for enhanced tumor-localized chemoimmunotherapy

Tianqi Wang et al.

NANOSCALE (2019)

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Review Gastroenterology & Hepatology

Hepatitis B Vaccine and Immunoglobulin: Key Concepts

Saibal Das et al.

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Paclitaxel-loaded nanoparticles decorated with bivalent fragment HAb18 F(ab′)2 and cell penetrating peptide for improved therapeutic effect on hepatocellular carcinoma

Cheng Jin et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery

Kalina Paunovska et al.

ACS NANO (2018)

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Article Oncology

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

Tatiana A. Karakasheva et al.

CANCER RESEARCH (2018)

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Review Biochemistry & Molecular Biology

An overview on Vadimezan (DMXAA): The vascular disrupting agent

Amir Daei Farshchi Adli et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2018)

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Article Pharmacology & Pharmacy

Strategies for the treatment of HBV/HDV

Andreas Krause et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

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Review Oncology

Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments

Mario Petrillo et al.

FUTURE ONCOLOGY (2018)

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Article Gastroenterology & Hepatology

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

Tian Lan et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Vitamin A-coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis

Hirotaka Furuhashi et al.

HEPATOLOGY RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Vitamin A-decorated biocompatible micelles for chemogene therapy of liver fibrosis

Jian-Bin Qiao et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Gastroenterology & Hepatology

Determinants of fibrosis progression and regression in NASH

Detlef Schuppan et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors

Eleonora De Martin et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Biology

Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model

Anna Konstorum et al.

JOURNAL OF THEORETICAL BIOLOGY (2018)

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Review Medicine, General & Internal

Overexpression of glypican-3 is a predictor of poor prognosis in hepatocellular carcinoma An updated meta-analysis

Jian Zhang et al.

MEDICINE (2018)

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Article Chemistry, Medicinal

Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib

Wendu Duan et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

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Review Immunology

Hypoxia-Driven immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational immunotherapy

Yiliang Li et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Actively Targeted Magnetothermally Responsive Nanocarriers/Doxorubicin for Thermochemotherapy of Hepatoma

Minghua Li et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Targeting Nanocarriers with Anisamide: Fact or Artifact?

Athanasia Dasargyri et al.

ADVANCED MATERIALS (2017)

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Review Immunology

Dendritic cells as gatekeepers of tolerance

Ari Waisman et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

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Article Nanoscience & Nanotechnology

Polyethylene glycol-poly(ε-benzyloxycarbonyl-llysine)-conjugated VEGF siRNA for antiangiogenic gene therapy in hepatocellular carcinoma

Gangmin Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Engineering, Biomedical

Resveratrol-loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles wrapping resveratrol nanoparticles: Preparation, characterization, and targeting effect on liver tumors

Mingfang Wu et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2017)

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Article Chemistry, Multidisciplinary

SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles

Nadine Leber et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Gastroenterology & Hepatology

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

JOURNAL OF HEPATOLOGY (2017)

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Review Biochemistry & Molecular Biology

The biology of Hepatocellular carcinoma: implications for genomic and immune therapies

Galina Khemlina et al.

MOLECULAR CANCER (2017)

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Editorial Material Biotechnology & Applied Microbiology

Novel strategies in vaccine design: can nanocapsules help prevent and treat hepatitis B?

Stephan Gehring et al.

NANOMEDICINE (2017)

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Review Gastroenterology & Hepatology

Autoimmune hepatitis: standard treatment and systematic review of alternative treatments

Benedetta Terziroli Beretta-Piccoli et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

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Article Multidisciplinary Sciences

Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors

Yunching Chen et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

Krishna S. Tummala et al.

CELL REPORTS (2017)

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Article Medicine, Research & Experimental

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes

Pia Svendsen et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2017)

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Review Anatomy & Morphology

The stellate cell system (vitamin A-storing cell system)

Haruki Senoo et al.

ANATOMICAL SCIENCE INTERNATIONAL (2017)

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Article Biochemistry & Molecular Biology

EGFR Signaling in Liver Diseases

Karin Komposch et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Cell Biology

Role of aetiology in the progression, regression, and parenchymal remodelling of liver disease: implications for liver biopsy interpretation

Alberto Quaglia et al.

HISTOPATHOLOGY (2016)

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Review Medicine, Research & Experimental

Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy

Yuee Cai et al.

MOLECULAR PHARMACEUTICS (2016)

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Article Nanoscience & Nanotechnology

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

Takashi K. Kishimoto et al.

NATURE NANOTECHNOLOGY (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

Hepatic Steatosis: Etiology, Patterns, and Quantification

Ilkay S. Idilman et al.

SEMINARS IN ULTRASOUND CT AND MRI (2016)

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Article Chemistry, Multidisciplinary

Corona-Directed Nucleic Acid Delivery into Hepatic Stellate Cells for Liver Fibrosis Therapy

Zhengping Zhang et al.

ACS NANO (2015)

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Article Cell Biology

TGF-β Regulates Hepatocellular Carcinoma Progression by Inducing Treg Cell Polarization

Yinan Shen et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)

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Review Endocrinology & Metabolism

Cushing's syndrome: update on signs, symptoms and biochemical screening

Lynnette K. Nieman

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2015)

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Article Immunology

Prevalence of Hepatitis A virus (HAV) and Hepatitis E virus (HEV) in the patients presenting with acute viral hepatitis

A. Joon et al.

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY (2015)

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Article Gastroenterology & Hepatology

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

Antonella Carambia et al.

JOURNAL OF HEPATOLOGY (2015)

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Article Medicine, General & Internal

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

Brent A. Neuschwander-Tetri et al.

LANCET (2015)

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Article Chemistry, Multidisciplinary

The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension

Hien T. T. Duong et al.

SMALL (2015)

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Article Oncology

Hepatoma-derived growth factor/nucleolin axis as a novel oncogenic pathway in liver carcinogenesis

San-Cher Chen et al.

ONCOTARGET (2015)

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Article Engineering, Biomedical

In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles

Leonard Kaps et al.

ADVANCED HEALTHCARE MATERIALS (2015)

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Article Gastroenterology & Hepatology

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

Giusi Marrone et al.

GUT (2015)

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Article Multidisciplinary Sciences

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

Roberto A. Maldonado et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Medicine, General & Internal

Anti-CD163-dexamethasone protects against apoptosis after ischemia/reperfusion injuries in the rat liver

Lin Nanna Okholm Moller et al.

ANNALS OF MEDICINE AND SURGERY (2015)

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Article Chemistry, Multidisciplinary

pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma

Daishun Ling et al.

ACS NANO (2014)

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Article Oncology

Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma

Bao-guang Hu et al.

EXPERIMENTAL CELL RESEARCH (2014)

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Article Gastroenterology & Hepatology

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells

Antonella Carambia et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Relaxin decreases the severity of established hepatic fibrosis in mice

Robert G. Bennett et al.

LIVER INTERNATIONAL (2014)

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Review Pharmacology & Pharmacy

The types of hepatic rnyofibroblasts contributing to liver fibrosis of different etiologies

Jun Xu et al.

FRONTIERS IN PHARMACOLOGY (2014)

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Article Gastroenterology & Hepatology

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells

Antonella Carambia et al.

JOURNAL OF HEPATOLOGY (2013)

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Article Multidisciplinary Sciences

Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury

Marike Marjolijn van Beuge et al.

PLOS ONE (2013)

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Article Plant Sciences

Dual ligands modified double targeted nano-system for liver targeted gene delivery

Fanbo Jing et al.

PHARMACEUTICAL BIOLOGY (2013)

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Review Oncology

A meta-analysis comparing simultaneous versus delayed resections in patients with synchronous colorectal liver metastases

A. A. P. Slesser et al.

SURGICAL ONCOLOGY-OXFORD (2013)

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Article Engineering, Biomedical

CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma

Lina Wang et al.

BIOMATERIALS (2012)

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Article Environmental Sciences

Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats

Devaraj Ezhilarasan et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2012)

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Article Gastroenterology & Hepatology

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

Guanhua Xie et al.

GASTROENTEROLOGY (2012)

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Article Multidisciplinary Sciences

Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer

Ling Meng et al.

PLOS ONE (2012)

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Article Gastroenterology & Hepatology

Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins

Ruomei Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)

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Review Gastroenterology & Hepatology

Treatment of autoimmune hepatitis: A review of current and evolving therapies

Dinesh Jothimani et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2011)

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Article Pharmacology & Pharmacy

Reduction of Fibrogenesis by Selective Delivery of a Rho Kinase Inhibitor to Hepatic Stellate Cells in Mice

M. M. van Beuge et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

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Article Medicine, Research & Experimental

Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis

Ruchi Barisal et al.

MOLECULAR PHARMACEUTICS (2011)

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Article Chemistry, Multidisciplinary

Bioimaging for Targeted Delivery of Hyaluronic Acid Derivatives to the Livers in Cirrhotic Mice Using Quantum Dots

Ki Su Kim et al.

ACS NANO (2010)

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Review Pathology

The Role of Liver Sinusoidal Cells in Hepatocyte-Directed Gene Transfer

Frank Jacobs et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Review Cell Biology

Hepatic stellate cell (vitamin A-storing cell) and its relative - past, present and future

Haruki Senoo et al.

CELL BIOLOGY INTERNATIONAL (2010)

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Review Immunology

Immune tolerance: What is unique about the liver

Gisa Tiegs et al.

JOURNAL OF AUTOIMMUNITY (2010)

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Article Gastroenterology & Hepatology

Priming of CD4+ T Cells by Liver Sinusoidal Endothelial Cells Induces CD25low Forkhead Box Protein 3- Regulatory T Cells Suppressing Autoimmune Hepatitis

Nils Kruse et al.

HEPATOLOGY (2009)

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Article Gastroenterology & Hepatology

Hepatic Regulatory T Cells and Kupffer Cells Are Crucial Mediators of Systemic T Cell Tolerance to Antigens Targeting Murine Liver

Ekaterina Breous et al.

HEPATOLOGY (2009)

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Article Immunology

Human Liver Dendritic Cells Promote T Cell Hyporesponsiveness

Zubin M. Bamboat et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Gastroenterology & Hepatology

Liver Sinusoidal Endothelial Cells Depend on Mannose Receptor-Mediated Recruitment of Lysosomal Enzymes for Normal Degradation Capacity

Kjetil Elvevold et al.

HEPATOLOGY (2008)

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Article Chemistry, Physical

Hydrophilic Monodisperse Magnetic Nanoparticles Protected by an Amphiphilic Alternating Copolymer

Eleonora V. Shtykova et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2008)

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Article Oncology

Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery

Albert Lo et al.

MOLECULAR CANCER THERAPEUTICS (2008)

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Article Oncology

Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis

Stephanie Gout et al.

CLINICAL & EXPERIMENTAL METASTASIS (2008)

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Article Oncology

Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

Su Young Kim et al.

CLINICAL & EXPERIMENTAL METASTASIS (2008)

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Article Oncology

Prognosis of perihilar cholangiocarcinoma: Hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus

Tsuyoshi Sano et al.

ANNALS OF SURGICAL ONCOLOGY (2008)

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Review Allergy

Hepatitis B virus (HBV) and autoimmune disease

Ram Maya et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2008)

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Article Oncology

Risk factors of biliary tract cancer in a large-scale population-based cohort study in Japan (JPHC study); with special focus on cholelithiasis, body mass index, and their effect modification

Seiji Ishiguro et al.

CANCER CAUSES & CONTROL (2008)

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Article Dermatology

RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts

Qiong Wang et al.

EXPERIMENTAL DERMATOLOGY (2007)

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Article Gastroenterology & Hepatology

The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor

Ivana Malovic et al.

HEPATOLOGY (2007)

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Article Multidisciplinary Sciences

A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

Riki Kawaguchi et al.

SCIENCE (2007)

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Article Oncology

HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma

Jing Xu et al.

MOLECULAR CANCER RESEARCH (2007)

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Article Gastroenterology & Hepatology

Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation

RE Perri et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

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Article Biochemistry & Molecular Biology

Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics

ZH Li et al.

FASEB JOURNAL (2005)

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Article Pharmacology & Pharmacy

The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue

L Beljaars et al.

BIOCHEMICAL PHARMACOLOGY (2003)

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Article Immunology

The role of virus-specific CD8+ cells in liver damage and viral control during persistent hepatitis B virus infection

MK Maini et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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Article Biochemistry & Molecular Biology

Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor

L Beljaars et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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