Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 16, Pages 3340-3342Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09689d
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Funding
- National Natural Science Foundation [81202474, 81273464, 81473146]
- Changzhou Special Project of Biotechnology and Biopharmacy [CE20105006]
- Science Bridges China-Changzhou Biotechnology and Pharmaceutical Technology Special Project [CE20105006]
- Qing Lan Project
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The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye. Upon NIR laser irradiation at 808 nm, ICG in the liposomes containing ICG and Ce6 could be degraded, while the phototoxicity of Ce6 could be recovered. In addition, we demonstrate that this newly developed liposomal component can be successfully used for activatable PDT to destroy cancer cells in vitro.
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