Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review

The homeobox A10 (HOXA10) gene is known to be related to endometriosis; however, due to a lack of knowledge/evidence in the pathogenesis of endometriosis, the mechanisms that link HOXA10 to endometriosis still need to be clarified. This review addresses the difference in the expression of the HOXA10 gene in endometriotic women versus non-endometriotic women across populations by country and discusses its influences on women's fertility. An organized search of electronic databases was conducted in Scopus, ScienceDirect, PubMed, and Web of Science. The keywords used were (HOXA10 OR homeobox A10 OR PL OR HOX1 OR HOX1H OR HOX1.8) AND (gene expression) AND (endometriosis). The initial search resulted in 623 articles, 10 of which were included in this review. All ten papers included in this study were rated fair in terms of the quality of the studies conducted. The expression of the HOXA10 gene was found to be downregulated in most studies. However, one study provided evidence of the downregulation and upregulation of HOXA10 gene expression due to the localization of endometriotic lesions. Measuring the expression of the HOXA10 gene in women is clinically essential to predicting endometriosis, endometrial receptivity, and the development of pinopodes in the endometrium during the luteal phase.

Automated summary

This review examines the expression differences of the HOXA10 gene in women with endometriosis compared to those without, across different countries, and discusses its impact on women's fertility. The majority of studies found downregulation of the HOXA10 gene expression, although one study showed evidence of both downregulation and upregulation depending on the localization of endometriotic lesions. Clinically, measuring the expression of the HOXA10 gene is crucial in predicting endometriosis, endometrial receptivity, and the development of pinopodes during the luteal phase.