4.7 Review

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Related references

Note: Only part of the references are listed.
Article Otorhinolaryngology

Transcanal Endoscopic Retrograde Mastoidectomy for Cholesteatoma: A Prospective Study

Dipesh Shakya et al.

Summary: This study evaluated the feasibility, morphological, and functional outcomes of endoscopic retrograde transcanal mastoidectomy for treating cholesteatoma. The results showed excellent outcomes, with high graft uptake rate and improved hearing post-surgery.

ENT-EAR NOSE & THROAT JOURNAL (2023)

Article Otorhinolaryngology

Changes in Coagulation Study and Risk of Developing Cholesteatoma: Is There a Link?

Joana Raquel Costa et al.

Summary: This study aimed to investigate the relationship between acquired pediatric cholesteatoma and dysfunctions in coagulation factors, highlighting their role in angiogenesis. A retrospective case-control study found that a slight extension of partial thromboplastin times in the coagulation study may be associated with the development of cholesteatoma in children.

JOURNAL OF AUDIOLOGY AND OTOLOGY (2023)

Review Otorhinolaryngology

Mastoid obliteration versus canal wall down or canal wall up mastoidectomy for cholesteatoma: Systematic review and meta-analysis

J. Salem et al.

Summary: This review examined the optimal surgical approach for cholesteatoma treatment and found that canal-wall down with mastoid obliteration achieved better outcomes compared to other approaches, including lower recurrence rates and incidence of persistent otorrhoea.

AMERICAN JOURNAL OF OTOLARYNGOLOGY (2023)

Article Oncology

BMI-1 promotes breast cancer proliferation and metastasis through different mechanisms in different subtypes

Jin-Yan Liu et al.

Summary: BMI-1 plays different roles in different types of breast cancer by inhibiting the transcription factors BRCA1 or CDKN2D, thereby promoting cell proliferation and migration.

CANCER SCIENCE (2023)

Article Environmental Sciences

MiR-26a-5p from HucMSC-derived extracellular vesicles inhibits epithelial mesenchymal transition by targeting Adam17 in silica-induced lung fibrosis

Jing Zhao et al.

Summary: Silicosis is caused by long-term inhalation of respirable crystalline silica and can be fatal. Previous studies have shown that epithelial-mesenchymal transition (EMT) plays a significant role in the fibrosis effect of silicosis. Human umbilical cord mesenchymal stem cells-derived Extracellular vesicles (hucMSC-EVs) have potential therapeutic effects on EMT and fibrosis-related diseases, but their effects and underlying mechanisms on silicosis-induced fibrosis are still unclear. This study observed the inhibitory effects and mechanism of hucMSC-EVs on EMT using an EMT model in MLE-12 cells. The results showed that hucMSC-EVs can indeed inhibit EMT. MiR-26a-5p, which is enriched in hucMSC-EVs, was down-regulated in silicosis mice. It was found that miR-26a-5p from hucMSC-EVs was involved in inhibiting EMT in silica-induced lung fibrosis by inhibiting the Adam17/Notch signaling pathway. These findings provide new insights into the treatment of silicosis fibrosis.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023)

Article Otorhinolaryngology

Endoscopic diving technique for hearing preservation in managing labyrinth-invading cholesteatomas

Selcuk Mulazimoglu et al.

Summary: This study presents a novel method of underwater endoscopic labyrinth dissection using continuous steroid irrigation (CSI) and systemic steroid administration for hearing preservation in cases of extensive cholesteatoma. The technique demonstrated successful preservation of membranous structures and cochlear function.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2023)

Review Biochemistry & Molecular Biology

A review on cyclin-dependent kinase 5: An emerging drug target for neurodegenerative diseases

Shivani Batra et al.

Summary: Cyclin-dependent kinase 5 (CDK5) is a serine/threonine-directed kinase primarily found in the brain that plays a crucial role in the development of the central nervous system. Recent research has shown that CDK5 is activated by specific cyclins, which regulate its expression and activity. This review examines the role of CDK5 in neurons, synaptic plasticity, DNA damage repair, and the cell cycle, highlighting its therapeutic potential as a target for neurodegenerative diseases. The structural features of CDK5 and its binding with designed inhibitors are also discussed, providing insights for the development of attractive strategies in therapeutic targeting.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

Article Biochemistry & Molecular Biology

MiR-125 family improves the radiosensitivity of head and neck squamous cell carcinoma

Qi-Wei Wang et al.

Summary: MiR-125 family members have different expression levels in head and neck squamous cell carcinoma (HNSCC) and are associated with tumor-node-metastasis staging, clinical stages, and histological grades. Specifically, miR-125a-5p is related to the effect of radiotherapy in laryngeal squamous cell cancer (LSCC) and can increase the sensitivity of LSCC to radiotherapy by activating P53. Upregulating miR-125a-5p can enhance the effect of radiotherapy on LSCC.

MOLECULAR BIOLOGY REPORTS (2023)

Review Pathology

miRNAs as potential game-changers in bone diseases: Future medicinal and clinical uses

Ahmed S. Doghish et al.

Summary: MicroRNAs (miRNAs), short and highly conserved non-coding RNA, influence gene expression through mechanisms such as mRNA degradation or translational repression. Changes in miRNA expression have an impact on cellular homeostasis and the development of various diseases. Recent studies have shown that miRNAs are involved in different stages of bone development and growth. Abnormal production of miRNA in bone tissues is closely associated with the development of bone disorders. Understanding the clinical relevance of miRNAs in bone diseases can provide insights for potential therapeutic targets.

PATHOLOGY RESEARCH AND PRACTICE (2023)

Article Gastroenterology & Hepatology

Comprehensive analysis of CDK5 as a novel biomarker for progression in esophageal cancer

Rui Ling et al.

Summary: This study analyzed the expression, predicted value, clinical relationship, functional enrichment, immune cell infiltration, and immune molecules of CDK5 in esophageal cancer (ESCA). It also explored the impact of CDK5 on proliferation, migration, and invasion behaviors of esophageal squamous cell carcinoma (ESCC) cells. The results showed that CDK5 was upregulated in ESCA and correlated with race, weight, BMI, histological type, and tumor central location. Functional experiments confirmed that CDK5 is an oncogene in ESCC.

ESOPHAGUS (2023)

Article Otorhinolaryngology

The Risk of Cholesteatoma in Individuals With First-degree Relatives Surgically Treated for the Disease

Asa Bonnard et al.

Summary: This study using nationwide register data in Sweden suggests that the risk of cholesteatoma in the middle ear is strongly associated with a family history of the condition. However, family history is rare and can only explain a limited number of cases, making families an important source of information regarding the genetic background of cholesteatoma disease.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2023)

Article Oncology

miR-146a-5p Promotes Angiogenesis and Confers Trastuzumab Resistance in HER2+Breast Cancer

Paula Cabello et al.

Summary: The expression of miR-146a-5p is associated with the efficacy and survival of HER2-positive breast cancer patients treated with trastuzumab. Increased expression of miR-146a-5p leads to resistance to trastuzumab and enhances cell migration and angiogenesis, promoting cell cycle progression. Furthermore, exosomes from trastuzumab-resistant cells, which contain high levels of miR-146a-5p expression, can transfer resistance properties to other cells.

CANCERS (2023)

Article Biochemistry & Molecular Biology

Regulating POLR3G by MicroRNA-26a-5p as a promising therapeutic target of lung cancer stemness and chemosensitivity

Chang Ryul Park et al.

Summary: Cancer stem cells (CSCs) in lung cancer have resistance to therapy, and miR-26a-5p has been found to play a role in suppressing lung cancer stemness and making cancer cells sensitive to chemotherapy. It was discovered that miR-26a-5p directly regulates the expression of RNA polymerase III subunit G (POLR3G) and its overexpression reduces colony and sphere formation. Additionally, high miR-26a-5p and low POLR3G expression are related to higher survival rate in patients with lung adenocarcinoma.

NON-CODING RNA RESEARCH (2023)

Article Otorhinolaryngology

Expression and Correlation Research of MicroRNA-10a-5p and PIK3CA in Middle Ear Cholesteatoma

Jing Yang et al.

Summary: This study found that miR-10a-5p expression was lower in middle ear cholesteatoma tissues, while PIK3CA expression was higher. miR-10a-5p may affect the growth and differentiation of cholesteatoma by negatively regulating the PIK3CA gene.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY (2023)

Letter Otorhinolaryngology

Bone Damage in Chronic Otitis Media

Jerzy Kuczkowski et al.

Summary: Bone destruction in chronic otitis media is activated and regulated by inflammation, with cytokines released from granulation and cholesteatoma exacerbating bone lysis in the middle ear.

ENT-EAR NOSE & THROAT JOURNAL (2022)

Article Cell Biology

miR-26a-5p suppresses nasopharyngeal carcinoma progression by inhibiting PTGS2 expression

Binlin Cai et al.

Summary: This study found that miR-26a-5p can regulate the growth and invasion ability of nasopharyngeal carcinoma cells by inhibiting PTGS2. This is of great significance for a better understanding of the pathogenesis and development of nasopharyngeal carcinoma.

CELL CYCLE (2022)

Review Cell Biology

Circular RNA in cancer development and immune regulation

Weizhen Li et al.

Summary: Circular RNAs (circRNAs) are a class of closed loop structures formed by covalent bonds of head and tail, and play important roles in regulating gene transcription and translation. They have been found to contribute to cancer development and have potential as biomarkers and therapeutic targets. Furthermore, circRNAs are involved in immune regulation and antitumor immunotherapy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Article Biochemistry & Molecular Biology

MiR-142-5p directly targets cyclin-dependent kinase 5-mediated upregulation of the inflammatory process in acquired middle ear cholesteatoma

Rongcui Sui et al.

Summary: MiR-142-5p regulates the inflammatory response in AMEC by directly inhibiting the CDK5-mediated upregulation of inflammatory cytokines.

MOLECULAR IMMUNOLOGY (2022)

Article Otorhinolaryngology

Incidence and trends of middle ear cholesteatoma surgery and mastoidectomy in Australia-A national hospital morbidity database analysis

Jonathan Li et al.

Summary: The incidence rate of cholesteatoma surgery in Australia is estimated at 8.6 per 100,000. Mastoidectomy continues to play an essential role in cholesteatoma surgery with a trend favoring canal wall up mastoidectomy over canal wall down mastoidectomy.

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY (2022)

Article Oncology

Polycomb Protein BMI-1 as a Potential Therapeutic Target in Mucinous Ovarian Cancer

Salem Abobaker et al.

Summary: This study investigated the correlation of BMI-1 expression in mOC patients and found no significant association with patient age, stage, lymph node status, and family history. Additionally, BMI-1 expression was not associated with progression-free survival.

ANTICANCER RESEARCH (2022)

Article Biotechnology & Applied Microbiology

MiR-1297 and MiR-26a-5p Inhibit Cell Progression of Keratinocytes in Cholesteatoma Depending on the Regulation of BMI1

Xiaodan Zhu et al.

Summary: Cholesteatoma is a middle ear disease characterized by the abnormal expression of BMI1, which plays an important role in its development. This study revealed that BMI1 is a target of miR-1297 and miR-26a-5p, and it promotes the progression of cholesteatoma by regulating cell proliferation, migration, invasion, cell cycle, and apoptosis. The findings uncover new mechanisms underlying the development of cholesteatoma and provide potential strategies for its treatment.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2022)

Article Otorhinolaryngology

Prevalence and surgical management of cholesteatoma in Down Syndrome children

Anna Poliner et al.

Summary: The study found that the prevalence of cholesteatoma in Down Syndrome children is approximately 1%, with the disease often occurring in older patients and tending to involve tegmen and ossicular erosion in advanced cases. Successful management of these patients can be achieved with CWU surgery with consistent long-term follow-up and close monitoring to prevent delays in diagnosis and treatment.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2022)

Article Medical Laboratory Technology

LINC00240 knockdown inhibits nasopharyngeal carcinoma progress by targeting miR-26a-5p

Xing Chen et al.

Summary: This study reveals the regulatory functions of LINC00240 on nasopharyngeal carcinoma (NPC). Silencing LINC00240 can inhibit cell proliferation, invasion, migration, and angiogenesis, while promoting apoptosis via miR-26a-5p and EZH2 inhibition in NPC cells. These findings demonstrate the significant role of LINC00240 in the development of NPC.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

Review Endocrinology & Metabolism

Circular RNA: A novel and potential regulator in pathophysiology of schizophrenia

Mandakini Singh et al.

Summary: Circular RNAs (CircRNAs) are a type of non-coding RNA that play important roles in gene regulation and neurological functions, particularly in the context of schizophrenia. This review focuses on the expression and activities of circRNAs in the brain, peripheral blood, and exosomes, as well as their interactions with RNA binding proteins and nucleotide modifications. The therapeutic potential of circRNAs in schizophrenia is also discussed.

METABOLIC BRAIN DISEASE (2022)

Article Multidisciplinary Sciences

MiR-26a-5p as a useful therapeutic target for upper tract urothelial carcinoma by regulating WNT5A/β-catenin signaling

Yueh-Hua Chung et al.

Summary: This study investigates the expression of miR-26a-5p in upper tract urothelial carcinoma (UTUC) and its associated signaling network. The results demonstrate significant down-regulation of miR-26a-5p in UTUC tumors and its ability to inhibit cell proliferation and migration by reversing epithelial-to-mesenchymal transition (EMT) process.

SCIENTIFIC REPORTS (2022)

Article Biochemical Research Methods

miR-203 suppresses pancreatic cancer cell proliferation and migration by modulating DUSP5 expression

Zekiye Altan et al.

Summary: This study reveals that miR-203 regulates the expression of DUSP5 in pancreatic cancer cells, thereby restricting their proliferation and migration. These findings suggest that miR-203 could serve as a potential biomarker for the diagnosis and treatment of pancreatic cancer.

MOLECULAR AND CELLULAR PROBES (2022)

Article Oncology

MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell

Ming Li et al.

Summary: miR-26a-5p alleviates the progression of cervical cancer by suppressing proliferation, migration, and invasion through downregulating HSDL2.

BMC CANCER (2022)

Article Otorhinolaryngology

Middle ear cholesteatoma prevalence in over 3,600 children with Turner Syndrome

Ian Dorney et al.

Summary: This study investigated the prevalence of middle ear cholesteatoma in children with Turner syndrome and found that the rate of diagnosed middle ear cholesteatoma was 16 times higher in patients with Turner syndrome compared to children without Turner syndrome.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2022)

Article Medicine, General & Internal

Type 1 Tympanoplasty Outcomes between Cartilage and Temporal Fascia Grafts: A Long-Term Retrospective Study

Salvatore Ferlito et al.

Summary: This retrospective study compared the functional and anatomical results of using temporal fascia or tragal cartilage grafts in type 1 tympanoplasty. The study found that both graft types improved auditory outcomes and reduced air-bone gap, but cartilage grafts showed better long-term stability. Younger age and larger perforation size were predictors of long-term functional success.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Meta-analysis of miR-34 target mRNAs using an integrative online application

Matjaz Rokavec et al.

Computational and Structural Biotechnology Journal (2022)

Article Cell Biology

Long noncoding RNA TRG-AS1 protects against glucocorticoid-induced osteoporosis in a rat model by regulating miR-802-mediated CAB39/AMPK/SIRT-1/NF-κB axis

Wen Liu et al.

Summary: In this study, the regulatory role and potential mechanisms of TRG-AS1 on glucocorticoid-induced osteoporosis (OP) in rats were investigated. Results showed that up-regulation of TRG-AS1 protected against glucocorticoid-induced OP by modulating the miR-802-mediated CAB39/AMPK/SIRT-1/NF-kappa B axis.

HUMAN CELL (2022)

Article Cell & Tissue Engineering

miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure

Qingxi Qu et al.

Summary: miR-126-3p-hucMSCs-exosomes promote proliferation and inhibit apoptosis of ovarian granulosa cells, suggesting a potential therapeutic strategy for premature ovarian failure (POF) treatment.

STEM CELL RESEARCH & THERAPY (2022)

Article Geriatrics & Gerontology

Identification of miRNA-mRNA Pairs in the Alzheimer's Disease Expression Profile and Explore the Effect of miR-26a-5p/PTGS2 on Amyloid-β Induced Neurotoxicity in Alzheimer's Disease Cell Model

Tao Xie et al.

Summary: In this study, the researchers identified the key miRNA-mRNA pair, miR-26a-5p/PTGS2, in the progression of AD. They confirmed that PTGS2 is a direct target gene of miR-26a-5p and found that the expression of miR-26a-5p is up-regulated while PTGS2 is down-regulated in AD patients. Functional experiments showed that PTGS2 protects AD model cells by inhibiting proliferation and migration, while miR-26a-5p promotes their proliferation. Additionally, they discovered that baicalein may affect the progression of AD by regulating the expression of PTGS2.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Review Oncology

Dissecting the Roles of PDCD4 in Breast Cancer

Qian Cai et al.

Summary: The PDCD4 gene is located on chromosome 10q24 and encodes the PDCD4 protein, which can inhibit tumor progression and proliferation in breast cancer. Multiple regulators and biological processes control the expression of PDCD4, and its downregulation is associated with shorter overall survival in patients.

FRONTIERS IN ONCOLOGY (2022)

Article Neurosciences

Aberrant Expression of Serum MicroRNA-153 and-199a in Generalized Epilepsy and its Correlation with Drug Resistance

Mai A. Zahra et al.

Summary: This study explores the potential use of serum microRNAs (miRNAs) as noninvasive biomarkers for the diagnosis and early detection of generalized epilepsy. The results show that the expression levels of miRNA-153 and -199a are significantly downregulated in patients with generalized epilepsy compared to healthy controls. The combination of these miRNAs has high sensitivity and specificity in diagnosing generalized epilepsy, and can also differentiate between drug-resistant and drug-responsive patients.

ANNALS OF NEUROSCIENCES (2022)

Review Otorhinolaryngology

Updates in paediatric cholesteatoma

Nick Orobello et al.

Summary: Various surgical management options are available and associated with improved outcomes, enabling otologic surgeons to better care for pediatric patients with cholesteatoma.

CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY (2022)

Review Biochemistry & Molecular Biology

Roles of Exosomes in Chronic Rhinosinusitis: A Systematic Review

Karolina Dzaman et al.

Summary: This review examines the role of exosomes in chronic rhinosinusitis (CRS) and their potential applications. The findings suggest that exosomal biomarkers have promising clinical utility in the diagnosis and prognosis of CRS patients, and may also contribute to the identification of novel therapeutic targets. Furthermore, exosomes can serve as excellent materials for studying noninvasive proteomic alterations, which is important for the development of personalized medicine.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects

Silviu Stanciu et al.

Summary: Pancreatic cancer, although relatively rare, is becoming a leading cause of cancer death. Various risk factors, both modifiable and non-modifiable, contribute to its pathogenesis. Chronic inflammation plays a crucial role in the development of pancreatic cancer. The PI3K/AKT/mTOR signaling pathway is important in cell growth, survival, and motility.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biology

Long-Term Anatomical and Hearing Outcomes of Canal Wall down Tympanoplasty for Tympano-Mastoid Cholesteatoma: A 20-Year Retrospective Study

Salvatore Ferlito et al.

Summary: This study evaluated the residual rate and functional outcomes after ten years of canal wall down tympanoplasty (CWD) for tympano-mastoid cholesteatoma. The results showed that preserving the stapes superstructure was associated with better hearing outcomes, and CWD surgery allowed for effective long-term anatomical disease control.

LIFE-BASEL (2022)

Article Gastroenterology & Hepatology

Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3

Yingxin Wang et al.

Summary: The study revealed that circ_PGPEP1 is highly expressed in gastric cancer and its silencing can induce cell cycle arrest and apoptosis, while inhibiting proliferation, migration, and invasion. Moreover, circ_PGPEP1 regulates GC progression by sponging miR-1297 and influencing its downstream target, E2F3.

DIGESTIVE DISEASES AND SCIENCES (2021)

Article Medicine, Research & Experimental

MiR-10a-5p restrains the aggressive phenotypes of ovarian cancer cells by inhibiting HOXA1

Li-Jun Liu et al.

Summary: The study revealed that miR-10a-5p exerts suppressive effects in ovarian carcinoma by regulating HOXA1, leading to reduced invasive ability of OC cells.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

Article Clinical Neurology

Postoperative Recurrent Cholesteatoma in Rural Versus Urban Populations

Kenneth L. Kennedy et al.

Summary: Patients in rural communities have a higher risk of postoperative residual cholesteatoma and require more surgeries compared to those in urban settings. However, there were no significant differences in risk of recurrence, size of cholesteatoma, presence of complications, and ossicular chain integrity postoperatively between rural and urban patients.

OTOLOGY & NEUROTOLOGY (2021)

Review Medical Laboratory Technology

Dysfunction of miR-802 in tumors

Tong Gao et al.

Summary: miR-802 is abnormally expressed in various tumors, regulating multiple signaling pathways and being controlled by four ceRNAs. The research on miR-802 provides new insights for its potential applications in tumor diagnosis and treatment.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Article Pharmacology & Pharmacy

MiR-21 inhibits the proliferation of childhood cholesteatoma glioma cells by negatively regulating the expressions of PTEN and PDCD4

Xiaozhen Chen et al.

Summary: Inhibition of MiR-21 can effectively reduce the proliferation of cholesteatoma cells in children, potentially inducing apoptosis through negative regulation of PTEN and PDCD4 expressions. MiR-21 may serve as a promising target for the treatment of children with cholesteatoma.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2021)

Article Biotechnology & Applied Microbiology

miR-199a Targeting PNRC1 to Promote Keratinocyte Proliferation and Invasion in Cholesteatoma

Lihui Yao et al.

Summary: miR-199a is upregulated in cholesteatoma tissues, promoting proliferation, migration, and invasion of HaCaT cells. These findings provide insights into the molecular mechanism of cholesteatoma progression.

BIOMED RESEARCH INTERNATIONAL (2021)

Review Oncology

The comprehensive landscape of miR-34a in cancer research

Sijing Li et al.

Summary: miR-34 plays crucial roles in cancer, with its downstream targets involved in multiple signaling pathways and crucial biological processes. Among them, miR-34a is especially important and can effectively suppress tumor progression by combining with chemotherapy or radiotherapy.

CANCER AND METASTASIS REVIEWS (2021)

Article Medicine, Research & Experimental

miRNA-10a-5p inhibits cell metastasis in hepatocellular carcinoma via targeting SKA1

Duo Shen et al.

Summary: A variety of miRNAs are involved in the development of hepatocellular carcinoma (HCC), with miR-10a-5p playing a role in inhibiting the migration, invasion, and epithelial-mesenchymal transition of HCC cells. SKA1 has been identified as a downstream target of miR-10a-5p, and its overexpression can reverse the inhibitory effects of miR-10a-5p in HCC progression. Low expression of miR-10a-5p is associated with the malignant development of HCC.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

Review Cardiac & Cardiovascular Systems

miR-21 in Human Cardiomyopathies

Surina Surina et al.

Summary: miR-21, a 22-nucleotide long microRNA, plays a crucial role in various cardiomyopathies by regulating gene expression and providing cardiac protection after injury. It is also closely linked to cardiac dysfunctions such as hypertrophy and fibrosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Medicine, General & Internal

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

Matthew J. Page et al.

Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Health Care Sciences & Services

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA 2020 statement replaces the 2009 statement and includes new reporting guidance that reflects advances in systematic review methodology, with modifications in structure and presentation for easier implementation.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

Article Medicine, General & Internal

Hsa_circ_0074491 regulates the malignance of cholesteatoma keratinocytes by modulating the PI3K/Akt pathway by binding to miR-22-3p and miR-125a-5p An observational study

Yunlong Hu et al.

Summary: The study revealed that the circular RNA circ_0074491 is downregulated in cholesteatoma tissues, and its silencing promotes proliferation, migration, and invasion of cholesteatoma keratinocytes. Additionally, circ_0074491 was confirmed to act as a decoy for miR-22-3p and miR-125a-5p, activating the PI3K/Akt pathway to exert inhibitory effects in cholesteatoma.

MEDICINE (2021)

Article Multidisciplinary Sciences

TCF21 regulates miR-10a-5p/LIN28B signaling to block the proliferation and invasion of melanoma cells

Haijun Zhu et al.

Summary: The study confirmed that miR-10a-5p had lower expression in melanoma cells and high expression suppressed the proliferation, migration, and invasion abilities. It was also found that miR-10a-5p targeted LIN28B mRNA and decreased LIN28B protein expression. TCF21 upregulation led to decreased LIN28B expression and increased miR-10a-5p expression, revealing a potential regulatory relationship between TCF21 and miR-10a-5p in melanoma.

PLOS ONE (2021)

Article Anatomy & Morphology

Low PDCD4 Expression Is Associated With Poor Prognosis of Colorectal Carcinoma

Joo Young Kim et al.

Summary: PDCD4 is a tumor suppressor gene that inhibits tumor progression, and its low expression is associated with poor prognosis in colorectal cancer patients. The study found that low nuclear PDCD4 expression is related to aggressive behavior in tumors and can serve as a prognostic indicator for colorectal cancer patients.

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2021)

Review Biochemistry & Molecular Biology

let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation

David L. Bernstein et al.

Summary: The let-7 family of microRNAs is highly expressed in the cerebral and cardiovascular systems, and plays a role in cardiovascular diseases and associated inflammation. It is involved in the development and differentiation of embryonic stem cells in the cardiovascular system, and may serve as a research focus for potential therapeutic targets in cardiovascular diseases.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

Targeting PI3K/Akt signal transduction for cancer therapy

Yan He et al.

Summary: The PI3K/Akt signaling pathway plays a crucial role in cancer, and targeting inhibitors against it may aid in drug discovery. Additionally, combining pathway inhibitors with other cancer treatment strategies could be an effective approach to solving therapeutic dilemmas.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Biotechnology & Applied Microbiology

The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear

Hongwei Zheng et al.

Summary: This study successfully delivered the small molecule regulator mir-34a, rubine, to cells using nanotechnology, passively targeting tumor tissue through the EPR effect and inhibiting the growth of cholesteatoma cells. Results showed that nanoparticles could improve miR-34 expression in cells, regulate the expression of Bcl-2, Cdk6, and CyclinD1, and inhibit the proliferation and migration of tumor cells.

BIOENGINEERED (2021)

Article Biochemistry & Molecular Biology

Nanoliposomal Delivery of MicroRNA-203 Suppresses Migration of Triple-Negative Breast Cancer through Distinct Target Suppression

Shuxuan Song et al.

Summary: MicroRNAs, specifically miR-203, have been identified as tumor suppressors in breast cancer, and liposomal delivery of miR-203 can reverse aspects of breast cancer pathogenesis. Suppressing distinct mRNA target profiles, such as LASP1 and survivin by stable miR-203 expression or BMI1 by nanoliposomal delivery, can lead to loss of cancer cell migration.

NON-CODING RNA (2021)

Article Medicine, General & Internal

MiR-508-3p promotes proliferation and inhibits apoptosis of middle ear cholesteatoma cells by targeting PTEN/PI3K/AKT pathway

Dongliang Liu et al.

Summary: This study investigated the regulatory effect of miR-508-3p in middle ear cholesteatoma, revealing that miR-508-3p overexpression can promote cell proliferation, while PTEN can reverse its effect on cell proliferation. The findings suggest a potential regulatory axis involving hsa_circ_0000007/miR-508-3p/ PTEN/ PI3K/Akt in the development of cholesteatoma.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Keratinocytes-derived exosomal miRNA regulates osteoclast differentiation in middle ear cholesteatoma

NingYue Gong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Otorhinolaryngology

Cholesteatoma and family history: An international survey

Rachael Collins et al.

CLINICAL OTOLARYNGOLOGY (2020)

Review Cell Biology

Circular RNA in renal diseases

Juan Jin et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Fangfang Zhang et al.

NATURE COMMUNICATIONS (2020)

Letter Otorhinolaryngology

Prevalence of Cholesteatoma in Children With Down Syndrome Receiving Treatment at Pediatric Health Care Facilities

Alycia Spinner et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2020)

Review Pharmacology & Pharmacy

Circular RNA: A novel potential biomarker for skin diseases

Xiaoting Wu et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Otorhinolaryngology

Keratinocyte growth factor signaling promotes stem/progenitor cell proliferation under p63 expression during middle ear cholesteatoma formation

Tomomi Yamamoto-Fukuda et al.

CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY (2020)

Article Biotechnology & Applied Microbiology

miR-1297 Suppresses Osteosarcoma Proliferation and Aerobic Glycolysis by Regulating PFKFB2

Xiaohui Pan et al.

ONCOTARGETS AND THERAPY (2020)

Article Cell Biology

MiR-802 causes nephropathy by suppressing NE-κB-repressing factor in obese mice and human

Da Sun et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Neurosciences

Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling

Ryusuke Imai et al.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY (2019)

Review Cell Biology

Circular RNA in cardiovascular disease

M-Ashraf Altesha et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Oncology

Overview of microRNA-199a Regulation in Cancer

Qiwen Wang et al.

CANCER MANAGEMENT AND RESEARCH (2019)

Review Oncology

Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Evgeny Chirshev et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2019)

Article Medicine, General & Internal

Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma

Jian Zang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

Article Biology

microRNA-1297 involves in the progression of oral squamous cell carcinoma through PTEN

Limin Liang et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Medicine, General & Internal

Microarray Analysis of Differentially-expressed MicroRNAs in Acquired Middle Ear Cholesteatoma

Shumin Xie et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

Review Otorhinolaryngology

The genetics of cholesteatoma. A systematic review using narrative synthesis

B. A. Jennings et al.

CLINICAL OTOLARYNGOLOGY (2018)

Review Cell Biology

Osteoblast-osteoclast interactions

Xiao Chen et al.

CONNECTIVE TISSUE RESEARCH (2018)

Article Neurosciences

Circular RNA: a new star in neurological diseases

Tao-Ran Li et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2017)

Review Otorhinolaryngology

MicroRNAs: effective elements in ear-related diseases and hearing loss

Mohammad-Reza Mahmoudian-sani et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2017)

Article Otorhinolaryngology

Incidence, 10-year recidivism rate and prognostic factors for cholesteatoma

A. Britze et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2017)

Article Medicine, Research & Experimental

Is von Willebrand disease linked to cholesteatoma aetiology?

A. Reis Rego et al.

MEDICAL HYPOTHESES (2017)

Article Biochemistry & Molecular Biology

microRNA-1297 Inhibits the Growth and Metastasis of Colorectal Cancer by Suppressing Cyclin D2 Expression

Yanan Wang et al.

DNA AND CELL BIOLOGY (2017)

Article Fisheries

Immunomodulation: A definitive role of microRNA-142

Salil Sharma

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2017)

Review Anatomy & Morphology

MicroRNA-142 is a multifaceted regulator in organogenesis, homeostasis, and disease

Amit Shrestha et al.

DEVELOPMENTAL DYNAMICS (2017)

Article Otorhinolaryngology

MicroRNA-21 promotes the proliferation and invasion of cholesteatoma keratinocytes

Xiaohua Chen et al.

ACTA OTO-LARYNGOLOGICA (2016)

Review Medicine, Research & Experimental

Acquired cholesteatoma epithelial hyperproliferation: Roles of cell proliferation signal pathways

Shumin Xie et al.

LARYNGOSCOPE (2016)

Article Otorhinolaryngology

Classification of Cholesteatoma According to Growth Patterns

Leticia Schmidt Rosito et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2016)

Review Oncology

Progress on the relationship between miR-125 family and tumorigenesis

Hang Yin et al.

EXPERIMENTAL CELL RESEARCH (2015)

Article Otorhinolaryngology

Epidemiological study of cholesteatoma in Fukuoka City

S. Shibata et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2015)

Article Oncology

MicroRNA let-7a suppresses the growth and invasion of cholesteatoma keratinocytes

Wenjing Zhang et al.

MOLECULAR MEDICINE REPORTS (2015)

Article Biotechnology & Applied Microbiology

Inflammation-induced miR-802 promotes cell proliferation in cholesteatoma

Nan Li et al.

BIOTECHNOLOGY LETTERS (2014)

Article Otorhinolaryngology

Activation of the EGFR/Akt/NF-κB/cyclinD1 survival signaling pathway in human cholesteatoma epithelium

Wei Liu et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2014)

Article Immunology

Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway

Yuanyuan Xu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Sargachromanol G inhibits osteoclastogenesis by suppressing the activation NF-κB and MAPKs in RANKL-induced RAW 264.7 cells

Weon-Jong Yoon et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Otorhinolaryngology

Regulation of the Angiogenesis of Acquired Middle Ear Cholesteatomas by Inhibitor of DNA Binding Transcription Factor

Shinji Fukudome et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2013)

Article Otorhinolaryngology

Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem

Tomomi Yamamoto-Fukuda et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2012)

Article Medicine, Research & Experimental

Cholesteatoma growth and proliferation: Relevance with serpin B3

Kuen-Yao Ho et al.

LARYNGOSCOPE (2012)

Article Hematology

Neoangiogenesis contributes to the development of hemophilic synovitis

Suchitra S. l Acharya et al.

BLOOD (2011)

Article Hematology

Endothelial von Willebrand factor regulates angiogenesis

Richard D. Starke et al.

BLOOD (2011)

Article Medicine, Research & Experimental

Post-transcriptional Regulation by MicroRNA-21 and let-7a MicroRNA in Paediatric Cholesteatoma

X. Chen et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2011)

Article Otorhinolaryngology

Expression of Tumor Necrosis Factor-alpha, Interleukin-1 alpha, Interleukin-6 and Interleukin-10 in Chronic Otitis Media with Bone Osteolysis

Jerzy Kuczkowski et al.

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES (2011)

Article Otorhinolaryngology

Increased expression of p63 and survivin in cholesteatomas

H. R. Park et al.

ACTA OTO-LARYNGOLOGICA (2009)

Article Otorhinolaryngology

Expression of PTEN and phosphorylated Akt in human cholesteatoma epithelium

Tae Young Yune et al.

ACTA OTO-LARYNGOLOGICA (2009)

Article Medicine, Research & Experimental

MicroRNA Regulation of Cholesteatoma Growth

David R. Friedland et al.

LARYNGOSCOPE (2009)

Article Clinical Neurology

Cholesteatoma Growth and Proliferation: Posttranscriptional Regulation by MicroRNA-21

David R. Friedland et al.

OTOLOGY & NEUROTOLOGY (2009)

Article Multidisciplinary Sciences

A skin microRNA promotes differentiation by repressing 'stemness'

Rui Yi et al.

NATURE (2008)

Article Dermatology

Expression of BMI-1 in normal skin and inflammatory and neoplastic skin lesions

Christina M. Reinisch et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2007)

Article Otorhinolaryngology

Survival signaling and terminal differentiation in cholesteatoma epithelium

Margriet A. Huisman et al.

ACTA OTO-LARYNGOLOGICA (2007)

Article Otorhinolaryngology

Family cluster of cholesteatoma

P. Homoe et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2007)

Article Otorhinolaryngology

Apoptosis in the pathogenesis of cholesteatoma in adults

Ewa Olszewska et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2006)

Review Biochemistry & Molecular Biology

MicroRNAs: Genomics, biogenesis, mechanism, and function

DP Bartel

Article Medicine, Research & Experimental

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

KS Chan et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Medicine, General & Internal

Expression patterns of cytokeratins in cholesteatomas: Evidence of increased migration and proliferation

HJ Kim et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2002)