☆ 4.7 Review

Modeling Liver Development and Disease in a Dish

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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JOURNAL OF HEPATOLOGY (2019)

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Modelling the endocrine pancreas in health and disease

Mostafa Bakhti et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

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What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? The Importance of Bridging Studies and Species-Independent Correlates of Protection

Hana Golding et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

CELL (2018)

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Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

Suk Hyung Lee et al.

CELL (2018)

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Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

Xing Deng et al.

CELL STEM CELL (2018)

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Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Riccardo Barrile et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)

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The balancing act of the liver: tissue regeneration versus fibrosis

Lucia Cordero-Espinoza et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Development of the liver: Insights into organ and tissue morphogenesis

Elke A. Ober et al.

JOURNAL OF HEPATOLOGY (2018)

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An in vivo model of functional and vascularized human brain organoids

Abed AlFatah Mansour et al.

NATURE BIOTECHNOLOGY (2018)

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Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Georgios Vlachogiannis et al.

SCIENCE (2018)

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3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

A. M. Ortega-Prieto et al.

NATURE COMMUNICATIONS (2018)

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Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Herve Tiriac et al.

CANCER DISCOVERY (2018)

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The Generation and Application of Patient-Derived Xenograft Model for Cancer Research

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CANCER RESEARCH AND TREATMENT (2018)

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Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

Krijn K. Dijkstra et al.

CELL (2018)

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Progress and potential in organoid research

Giuliana Rossi et al.

NATURE REVIEWS GENETICS (2018)

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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Xiaodun Li et al.

NATURE COMMUNICATIONS (2018)

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Recapitulation of hepatitis B virus-host interactions in liver organoids from human induced pluripotent stem cells

Yun-Zhong Nie et al.

EBIOMEDICINE (2018)

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Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Huili Hu et al.

CELL (2018)

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Inflammatory Cytokine TNF alpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

Weng Chuan Peng et al.

CELL (2018)

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Alcoholic liver disease: Utility of animal models

Arantza Lamas-Paz et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

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Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Meike Hohwieler et al.

GUT (2017)

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Organoids: A historical perspective of thinking in three dimensions

Marina Simian et al.

JOURNAL OF CELL BIOLOGY (2017)

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Sodium Taurocholate Cotransporting Polypeptide Is the Limiting Host Factor of Hepatitis B Virus Infection in Macaque and Pig Hepatocytes

Florian A. Lempp et al.

HEPATOLOGY (2017)

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Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Alexander Raven et al.

NATURE (2017)

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Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

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Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells

Fotios Sampaziotis et al.

NATURE PROTOCOLS (2017)

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Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

Takanori Takebe et al.

CELL REPORTS (2017)

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Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration

Yangfei Xiang et al.

CELL STEM CELL (2017)

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Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological Systems

N. Tsamandouras et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

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Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

Jonathan J. Miner et al.

CELL (2016)

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Modeling Development and Disease with Organoids

Hans Clevers

CELL (2016)

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Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes

Zobair M. Younossi et al.

HEPATOLOGY (2016)

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Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Thomas J. Long et al.

DRUG METABOLISM AND DISPOSITION (2016)

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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch et al.

CELL (2015)

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Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

CELL (2015)

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Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

Bruce Wang et al.

NATURE (2015)

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Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Minoru Takasato et al.

NATURE (2015)

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Directed differentiation of cholangiocytes from human pluripotent stem cells

Mina Ogawa et al.

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Animal Models and the Molecular Biology of Hepadnavirus Infection

William S. Mason

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

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In vitro generation of human pluripotent stem cell derived lung organoids

Briana R. Dye et al.

ELIFE (2015)

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Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Ujjal Sarkar et al.

DRUG METABOLISM AND DISPOSITION (2015)

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Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao et al.

CELL (2014)

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Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

Tae-Young Choi et al.

GASTROENTEROLOGY (2014)

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Generation of Functional Cholangiocyte-Like Cells From Human Pluripotent Stem Cells and HepaRG Cells

Noushin Dianat et al.

HEPATOLOGY (2014)

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Organogenesis in a dish: Modeling development and disease using organoid technologies

Madeline A. Lancaster et al.

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Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?

Rafael Franco et al.

FRONTIERS IN PHARMACOLOGY (2014)

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch et al.

NATURE (2013)

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Vascularized and functional human liver from an iPSC-derived organ bud transplant

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NATURE (2013)

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Cerebral organoids model human brain development and microcephaly

Madeline A. Lancaster et al.

NATURE (2013)

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A functional CFTR assay using primary cystic fibrosis intestinal organoids

Johanna F. Dekkers et al.

NATURE MEDICINE (2013)

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TIMELINE Liver transplantation: past, present and future

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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)

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Genomic responses in mouse models poorly mimic human inflammatory diseases

Junhee Seok et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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In Vivo Maturation of Functional Renal Organoids Formed from Embryonic Cell Suspensions

Christodoulos Xinaris et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Signals and Cells Involved in Regulating Liver Regeneration

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Cells (2012)

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

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GASTROENTEROLOGY (2011)

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The Use of Whole Organ Decellularization for the Generation of a Vascularized Liver Organoid

Pedro M. Baptista et al.

HEPATOLOGY (2011)

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Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

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JOURNAL OF CLINICAL INVESTIGATION (2011)

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Self-formation of functional adenohypophysis in three-dimensional culture

Hidetaka Suga et al.

NATURE (2011)

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Self-organizing optic-cup morphogenesis in three-dimensional culture

Mototsugu Eiraku et al.

NATURE (2011)

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Extraordinary neoteny of synaptic spines in the human prefrontal cortex

Zdravko Petanjek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Nick Barker et al.

CELL STEM CELL (2010)

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Treatment of alcoholic liver disease

Thomas H. Frazier et al.

Therapeutic Advances in Gastroenterology (2010)

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Notch signaling controls liver development by regulating biliary differentiation

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DEVELOPMENT (2009)

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Discontinued drugs in 2008: endocrine and metabolic

Jerry R. Colca

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato et al.

NATURE (2009)

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Evolution of the neocortex: a perspective from developmental biology

Pasko Rakic

NATURE REVIEWS NEUROSCIENCE (2009)

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Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Mototsugu Eiraku et al.

CELL STEM CELL (2008)

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Stefano Romeo et al.

NATURE GENETICS (2008)

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Kazutoshi Takahashi et al.

CELL (2007)

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New animal models for hepatitis C viral infection and pathogenesis studies

Dina Kremsdorf et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2007)

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Kazutoshi Takahashi et al.

CELL (2006)

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Reconstruction of liver organoid using a bioreactor

Masaya Saito et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2006)

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Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique

YN Yan et al.

BIOMATERIALS (2005)

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Foveolar differentiation of mouse gastric mucosa in vitro

A Ootani et al.

AMERICAN JOURNAL OF PATHOLOGY (2003)

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Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver

Y Magami et al.

LIVER (2002)

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Helicobacter pylori and gastrointestinal tract adenocarcinomas

RM Peek et al.

NATURE REVIEWS CANCER (2002)

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