4.7 Article

Neurolysin Knockout Mice in a Diet-Induced Obesity Model

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice

Luis Felipe Galvao Valdivia et al.

Summary: This study found that cold acclimation and PPARγ agonism combined have additive effects in increasing UCP1 content and thermogenic capacity in brown and beige adipocytes, but do not increase basal energy expenditure.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2023)

Article Biochemistry & Molecular Biology

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials

Mihaela-Simona Popoviciu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Endocrinology & Metabolism

Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies

Maria Guaita-Cespedes et al.

Summary: The expression stability of classical housekeeping genes in human adipose tissue varies by sex, indicating that they are not suitable as internal controls. Some new potential housekeeping genes that are not affected by sex bias are proposed.

BIOLOGY OF SEX DIFFERENCES (2023)

Article Food Science & Technology

Micronutrients in High-Fat Diet Modify Insulin Resistance and Its Regulatory Genes in Adult Male Mice

Zeyu Yang et al.

Summary: In this study, the addition of micronutrients to a high-fat diet was found to decrease insulin resistance and modify associated gene expression in both obese and lean mice.

MOLECULAR NUTRITION & FOOD RESEARCH (2023)

Article Biochemistry & Molecular Biology

Expression of thimet oligopeptidase (THOP) modulated by oxidative stress in human multidrug resistant (MDR) leukemia cells

Raquel Leao Neves et al.

Summary: The study found that oxidative stress influences the expression and regulation of THOP in leukemia cells, which may affect the immune evasion of tumor cells. Additionally, the proteolytic activity of THOP is also associated with the cellular redox state.

BIOCHIMIE (2023)

Article Nutrition & Dietetics

Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice

Yermek Rakhat et al.

Summary: The first oral form of glucagon-like peptide-1 receptor agonist, oral semaglutide, effectively controls glycemia and body weight in subjects with type 2 diabetes. This study investigates the metabolic effects of oral semaglutide in mice under human protocols and doses. It is found that oral semaglutide rapidly decreases blood glucose and food intake and continuously suppresses feeding and weight in mice.

NUTRIENTS (2023)

Article Cell Biology

Effect of FKBP12-Derived Intracellular Peptides on Rapamycin-Induced FKBP-FRB Interaction and Autophagy

Carolina A. Parada et al.

Summary: This study investigates the intracellular effects of intracellular peptides on protein-protein interactions. The results show that VFD7 and VFD6 peptides can inhibit the rapamycin-induced interaction between FKBP and FRB. Molecular dynamics simulations suggest that VFD7 and VFD6 can bind to FKBP and induce structural changes, providing insights into their mechanism of PPI inhibition. Additionally, intracellular peptides are found to be mainly associated with macromolecular components. Overall, this study provides further evidence for the importance of intracellular peptides in the targeted design of therapeutic molecules for intracellular PPI.

CELLS (2022)

Review Biochemistry & Molecular Biology

New Insights in the Control of Fat Homeostasis: The Role of Neurotensin

Ilaria Barchetta et al.

Summary: Neurotensin (NT) plays an important role in controlling food intake and energy balance. Recent studies have shown that NT acts as a neurotransmitter in the central nervous system and brain circuits, producing different effects. It is also involved in the regulation of gut lipid absorption and fat homeostasis. High circulating levels of pro-NT, the stable precursor of NT, have been associated with an increased incidence of metabolic disorders, cardiovascular diseases, and cancer. This review provides an overview of NT's regulatory effects on various biological pathways, with a focus on its role in controlling fat homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice

Renata Silverio et al.

Summary: Oral administration of Pep19 can alleviate high-fat diet-induced obesity and have positive effects on metabolic traits, morphology, and behavior.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Medicine, Research & Experimental

Cellular expression of CD26/dipeptidyl peptidase IV

Toshihiko IWANAGA et al.

BIOMEDICAL RESEARCH-TOKYO (2021)

Article Cell Biology

White Adipose Tissue Depots Respond to Chronic Beta-3 Adrenergic Receptor Activation in a Sexually Dimorphic and Depot Divergent Manner

Eric D. Queathem et al.

Summary: The activation of Beta-3 adrenergic receptors by CL improves systemic and adipose tissue-specific metabolism in both sexes, with sex differences observed in the specific effects of CL on white adipose tissue. Furthermore, CL affects estrogen signaling by upregulating estrogen receptor beta across sexes and depots.

CELLS (2021)

Article Pharmacology & Pharmacy

New Intracellular Peptide Derived from Hemoglobin Alpha Chain Induces Glucose Uptake and Reduces Blood Glycemia

Renee N. O. Silva et al.

Summary: Intracellular peptides derived from skeletal muscle and adipose tissues play a role in regulating blood glucose levels and promoting muscle contraction in mice. Specifically, Ric4 and its derivatives show potential therapeutic effects in reducing glycemia.

PHARMACEUTICS (2021)

Review Endocrinology & Metabolism

Diet-induced obesity in animal models: points to consider and influence on metabolic markers

Mariana de Moura e Dias et al.

Summary: Overweight and obesity are global public health problems that have increased considerably in prevalence. Diet-induced obesity animal models can replicate human overweight and obesity, with various protocols to lead to excess fat deposition. Key points for inducing obesity through diet include evaluating body weight, fat gain, inflammation, hormonal concentration, blood glycemia, lipid profile, liver health, and considering diet composition and calorie overconsumption for obesity development.

DIABETOLOGY & METABOLIC SYNDROME (2021)

Review Endocrinology & Metabolism

Leptin: Is It Thermogenic

Alexander W. Fischer et al.

ENDOCRINE REVIEWS (2020)

Article Pharmacology & Pharmacy

Dietary antioxidants remodel DNA methylation patterns in chronic disease

Megan Beetch et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity

Mayara C. F. Gewehr et al.

BIOMOLECULES (2020)

Article Endocrinology & Metabolism

Aerobic exercise training regulates serum extracellular vesicle miRNAs linked to obesity to promote their beneficial effects in mice

Mariana de Mendonca et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Review Biochemistry & Molecular Biology

Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions

Emer S. Ferro et al.

BIOMOLECULES (2020)

Article Nutrition & Dietetics

High-Fat Diet Alters the Expression of Reference Genes in Male Mice

Xiuqin Fan et al.

FRONTIERS IN NUTRITION (2020)

Article Biochemistry & Molecular Biology

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

Olof S. Dallner et al.

NATURE MEDICINE (2019)

Review Endocrinology & Metabolism

Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

Network-based prediction of protein interactions

Istvan A. Kovacs et al.

NATURE COMMUNICATIONS (2019)

Review Endocrinology & Metabolism

Leptin resistance: underlying mechanisms and diagnosis

Olga Gruzdeva et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2019)

Review Biochemistry & Molecular Biology

Intracellular Peptides in Cell Biology and Pharmacology

Christiane B. de Araujo et al.

BIOMOLECULES (2019)

Article Biochemistry & Molecular Biology

Thimet Oligopeptidase (EC 3.4.24.15) Key Functions Suggested by Knockout Mice Phenotype Characterization

Nilton B. dos Santos et al.

BIOMOLECULES (2019)

Correction Nutrition & Dietetics

A review of the carbohydrate-insulin model of obesity (vol 71, pg 679, 2017)

K. D. Hall

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2018)

Article Multidisciplinary Sciences

Insulin-degrading enzyme is not secreted from cultured cells

Eun Suk Song et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling

Blanca E. Ruiz-Medina et al.

BIOCHEMICAL JOURNAL (2018)

Review Biochemistry & Molecular Biology

Neurolysin: From Initial Detection to Latest Advances

Frederic Checler et al.

NEUROCHEMICAL RESEARCH (2018)

Review Medicine, General & Internal

Mechanisms, Pathophysiology, and Management of Obesity

Steven B. Heymsfield et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

A novel peptide that improves metabolic parameters without adverse central nervous system effects

Patricia Reckziegel et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity

Jing Cui et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Endocrinology & Metabolism

Inhibition of Leptin-ObR Interaction Does not Prevent Leptin Translocation Across a Human Blood-Brain Barrier Model

D. Gonzalez-Carter et al.

JOURNAL OF NEUROENDOCRINOLOGY (2016)

Article Multidisciplinary Sciences

Analysis of the Yeast Peptidome and Comparison with the Human Peptidome

Sayani Dasgupta et al.

PLOS ONE (2016)

Article Cell Biology

Leptin Raises Defended Body Temperature without Activating Thermogenesis

Alexander W. Fischer et al.

CELL REPORTS (2016)

Article Endocrinology & Metabolism

Sex differences in sympathetic innervation and browning of white adipose tissue of mice

Sang-Nam Kim et al.

BIOLOGY OF SEX DIFFERENCES (2016)

Article Public, Environmental & Occupational Health

Consumption of ultra-processed foods and obesity in Brazilian adolescents and adults

Maria Laura da Costa Louzada et al.

PREVENTIVE MEDICINE (2015)

Article Multidisciplinary Sciences

Uncovering disease-disease relationships through the incomplete interactome

Joerg Menche et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

Antonis Koussounadis et al.

SCIENTIFIC REPORTS (2015)

Article Multidisciplinary Sciences

Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease

Sayani Dasgupta et al.

PLOS ONE (2015)

Article Biochemistry & Molecular Biology

Neurolysin Knockout Mice Generation and Initial Phenotype Characterization

Diogo M. L. P. Cavalcanti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemical Research Methods

Peptidomic analysis of the neurolysin-knockout mouse brain

Leandro M. Castro et al.

JOURNAL OF PROTEOMICS (2014)

Review Endocrinology & Metabolism

Personalized weight loss strategies-the role of macronutrient distribution

J. Alfredo Martinez et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Article Multidisciplinary Sciences

Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells

Sayani Dasgupta et al.

PLOS ONE (2014)

Article Cell Biology

Edgotype: a fundamental link between genotype and phenotype

Nidhi Sahni et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2013)

Article Endocrinology & Metabolism

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

M. K. Montgomery et al.

DIABETOLOGIA (2013)

Article Multidisciplinary Sciences

Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib

Julia S. Gelman et al.

PLOS ONE (2013)

Article Biochemical Research Methods

Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance

Denise A. Berti et al.

PROTEOMICS (2012)

Review Biochemistry & Molecular Biology

Interactome Networks and Human Disease

Marc Vidal et al.

Article Endocrinology & Metabolism

Regulation of energy balance by leptin

A. Hamann et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2009)

Article Biochemistry & Molecular Biology

Analysis of Intracellular Substrates and Products of Thimet Oligopeptidase in Human Embryonic Kidney 293 Cells

Denise A. Berti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemical Research Methods

Antibodies against G-protein coupled receptors: Novel uses in screening and drug development

Achla Gupta et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2008)

Article Biochemistry & Molecular Biology

Intracellular peptides as natural regulators of cell signaling

Fernanda M. Cunha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

The human disease network

Kwang-Il Goh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase

Eun Jeong Lim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia

NA Jeske et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Substrate phosphorylation affects degradation and interaction to endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme

MFM Machado et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Biochemistry & Molecular Biology

Intracellullar peptides as putative natural regulators of protein interactions

ES Ferro et al.

JOURNAL OF NEUROCHEMISTRY (2004)

Review Physiology

Brown adipose tissue: Function and physiological significance

B Cannon et al.

PHYSIOLOGICAL REVIEWS (2004)

Article Biochemistry & Molecular Biology

Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization

K Ray et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme

V Rioli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Physiology

Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity

BE Levin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2002)