A Two-Step Transcriptome Analysis of the Human Heart Reveals Broad and Disease-Responsive Expression of Ectopic Olfactory Receptors

Article Biochemistry & Molecular Biology

FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome

Naixin Zhang et al.

Summary: HFpEF-MetS is a complex clinical syndrome, and metabolic syndrome plays a major role in its pathogenesis. Ffar4 can attenuate remodeling and resolve inflammation in HFpEF-MetS.

JOURNAL OF LIPID RESEARCH (2023)

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Article Multidisciplinary Sciences

ExpressAnalyst: A unified platform for RNA-sequencing analysis in non-model species

Peng Liu et al.

Summary: ExpressAnalyst is a web-based platform that efficiently processes and analyzes RNA-sequencing data from any eukaryotic species, providing statistical and functional analysis. It includes modules for processing and annotating FASTQ files, as well as analyzing count tables or gene lists. By integrating ultra-fast read mapping algorithms with high-resolution ortholog databases, ExpressAnalyst enables researchers to obtain global expression profiles and gene-level insights within 24 h.

NATURE COMMUNICATIONS (2023)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: The American Heart Association, in collaboration with the National Institutes of Health, releases annual statistics on heart disease, stroke, and cardiovascular risk factors. The Statistical Update provides the latest data on various heart and circulatory diseases and their outcomes, as well as information on core health behaviors and factors contributing to cardiovascular health.

CIRCULATION (2023)

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Review Food Science & Technology

Human ectopic olfactory receptors and their food originated ligands: a review

Rifat Nowshin Raka et al.

Summary: Ectopic olfactory receptors (EORs) are expressed in non-nasal tissues of the human body and can be triggered by odorants, participating in various biological processes. Consumption of strongly flavored foods can help reduce inflammation and boost the immune system.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Article Cardiac & Cardiovascular Systems

Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload

Katherine A. Murphy et al.

Summary: The study found that Ffar4 plays a protective role in the heart and can alleviate cardiac damage caused by pressure overload. Ffar4 protects cardiac myocytes from pathological stress by reducing oxidative injury and increasing the production of specific lipids.

CARDIOVASCULAR RESEARCH (2022)

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Review Peripheral Vascular Disease

Short-Chain Fatty Acid Receptors and Blood Pressure Regulation: Council on Hypertension Mid-Career Award for Research Excellence 2021

Jiaojiao Xu et al.

Summary: The gut microbiome, through the production of SCFAs, plays a role in blood pressure regulation and cardiovascular disease. This review discusses the various receptors and signaling pathways involved in SCFA-mediated blood pressure regulation and summarizes the phenotypes observed in knockout mice.

HYPERTENSION (2022)

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Article Cardiac & Cardiovascular Systems

Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017

Nicola Luigi Bragazzi et al.

Summary: This study provides a systematic analysis of the burden and underlying causes of heart failure (HF) in 195 countries and territories from 1990 to 2017. It found that while the age-standardized prevalence and YLD rates of HF have decreased globally, the absolute numbers of HF cases and YLDs have increased. Additionally, there is significant geographic and socio-demographic variation in the levels and trends of HF burden.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

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Article Biochemical Research Methods

Correlation AnalyzeR: functional predictions from gene co-expression correlations

Henry E. Miller et al.

Summary: Correlation AnalyzeR is a user-friendly tool that provides flexible access to co-expression databases for different tissues and diseases, and uses advanced computational tools to generate functional predictions. By exploring gene relationships, novel biological insights can be revealed.

BMC BIOINFORMATICS (2021)

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Review Cardiac & Cardiovascular Systems

Consensus Transcriptional Landscape of Human End-Stage Heart Failure

Ricardo O. Ramirez Flores et al.

Summary: The study integrated 16 public transcriptomic studies to derive a consensus transcriptional signature of human end-stage HF. Through machine learning approaches and meta-analysis, it revealed consistent molecular changes across all studies.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Review Pharmacology & Pharmacy

Role of ectopic olfactory receptors in glucose and lipid metabolism

Siyu Zhang et al.

Summary: This review discusses the roles and mechanisms of ectopic ORs in regulating glucose and lipid metabolism, emphasizing their potential for treating the metabolic syndrome.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Zhiqiang Pang et al.

Summary: MetaboAnalyst version 5.0 has been introduced to facilitate comprehensive metabolomics data analysis and interpretation, with the aim of narrowing the gap from raw data to functional insights. Three new modules have been developed to assist in this goal, along with various other new functions and improvements in interface, graphics, and codebase. Users can now easily switch between compatible modules for a streamlined data analysis experience.

NUCLEIC ACIDS RESEARCH (2021)

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Article Urology & Nephrology

The Sniffing Kidney: Roles for Renal Olfactory Receptors in Health and Disease

Blythe D. Shepard

Summary: Olfactory receptors, despite their name, have functions outside of the nose, including in tissues such as the kidney. Renal ORs have been linked to various processes in maintaining renal homeostasis, such as blood pressure modulation, response to acidemia, and diabetes development. Recent progress has highlighted the growing importance of renal ORs in physiology and pathophysiology.

KIDNEY360 (2021)

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Article Multidisciplinary Sciences