Related references
Note: Only part of the references are listed.
Review
Environmental Sciences
Maria Joao Bessa et al.
Summary: Several studies have investigated the potential adverse health risks associated with exposure to nanoscale materials. In vitro model systems provide important information about the molecular mechanisms of action, while in vivo studies are crucial for understanding the relationship between dose and adverse effects. This review focuses on the toxicity assessment of inhaled (nano)particulate materials and provides an overview of available human respiratory models and exposure systems for in vitro testing, as well as their advantages, limitations, and current research.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Maria Joao Bessa et al.
Summary: This study assessed the toxicity of particles emitted from atmospheric plasma and high-velocity oxy-fuel thermal spraying, and found that they exerted different cytotoxic and genotoxic effects on human alveolar cells. The results emphasize the importance of considering the health risks of these process-generated particles in industrial settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Rosario et al.
Summary: Considering the increasing emergence of new contaminants and their interactions with legacy contaminants, this study aimed to assess and compare the toxic profile of titanium dioxide nanoparticles, cerium oxide nanoparticles, arsenic, and mercury on human liver cancer cells and neuroblastoma cells. The results showed that the viability and proliferation of cells were affected in a dose-, time-, and cell-dependent manner, with higher concentrations causing greater toxicity and prolonged exposure inhibiting cell proliferation. The cell cycle progression was also altered by the exposure to certain contaminants, and the joint toxicity of mixtures was found to have either potentiation or antagonistic effects depending on the composition, cell type, and exposure time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Environmental
Fan Zhang et al.
Summary: This review examines the toxicity of mixtures of engineered nano particles (ENPs) to different species. The majority of joint effects were found to be antagonistic, with a smaller percentage being synergistic or additive effects. Plants were more likely to experience antagonistic effects when exposed to mixtures of ENPs. Factors influencing the joint response include the chemical composition of the mixtures, stability of the suspensions, type and trophic level of organisms tested, exposure concentrations and time, toxicity endpoints, and abiotic field conditions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wen Yang et al.
Summary: This article reviews the potential adverse effects of nanoparticles on human health and discusses mechanisms of nanotoxicity, including the generation of reactive oxygen species, nanoparticle disintegration, and modulation of cell signaling pathways. Improved understanding of nanoparticle toxicity may lead to strategies for safe application of nanotechnology.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Biochemistry & Molecular Biology
Ana Carvalhais et al.
Summary: The study evaluated the toxicity of organic and inorganic UV filters on turbot, finding mild effects on liver metabolic function and behavior. Both isolated and combined exposure did not consistently increase toxicity, providing key information for environmentally safe sunscreen products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tahereh Ziglari et al.
Summary: Nanoparticle-induced lysosomal hyperpolarization triggers LMP, with a threshold of lysosomal membrane potential being crucial for the occurrence of LMP. The study suggests that lysosomal hyperpolarization is an early event leading to cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Svetlana V. Klinova et al.
Summary: The study found that subchronic intoxication induced by lead oxide and cadmium oxide nanoparticles, either alone or in combination, significantly reduced the mechanical work of myocardial preparations and decreased the sliding velocity of regulated thin filaments. These cardiotoxic effects were influenced by the toxic impact, toxicant doses, stretching of cardiomyocytes, and muscle type studied. Some of the toxic and genotoxic effects could be partially or fully normalized when intoxication occurred alongside the administration of a bioprotective complex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hung-Jin Huang et al.
Summary: Millions of experimental animals are widely used in evaluating the toxicological or biological effects of manufactured nanomaterials in medical technology, but the principle of the 3Rs is applied to ensure more ethical animal research. Alternative methods, such as in vitro and in silico approaches, have been employed to replace or reduce the use of experimental animals and have been implemented in many countries for scientific purposes. These non-animal approaches, including cell culture testing, tissue engineering, molecular docking, molecular dynamics simulations, and QSAR modeling, have the potential to help minimize the use of experimental animals for nanomaterial toxicity assessments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Fernandez-Bertolez et al.
Summary: The study aimed to determine if Cyt-B could interfere with MN induction by TiO2 NP in human cells using the CBMN test. The results showed that Cyt-B might alter the results of the CBMN assay. Additionally, comparisons between different treatment options indicated that they are not effective alternatives to avoid interference from Cyt-B in specific conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Ayse Busra Sengul et al.
ENVIRONMENTAL CHEMISTRY LETTERS
(2020)
Article
Biotechnology & Applied Microbiology
Tawfik A. Saleh
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2020)
Article
Chemistry, Multidisciplinary
Jennifer B. Raftis et al.
Review
Biochemistry & Molecular Biology
Yi Cao et al.
Review
Environmental Sciences
Steffi Naasz et al.
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Review
Environmental Sciences
Mirco Bundschuh et al.
ENVIRONMENTAL SCIENCES EUROPE
(2018)
Review
Nanoscience & Nanotechnology
Rui Deng et al.
Review
Engineering, Biomedical
Xiaohong Yu et al.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Multidisciplinary Sciences
Kimberly J. Ong et al.
