☆ 4.7 Review

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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LncRNA MALAT1 improves cerebral ischemia-reperfusion injury and cognitive dysfunction by regulating miR-142-3p/SIRT1 axis

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Long non-coding RNA TTTY15 sponges miR-520a- 3p to exacerbate neural apoptosis induced by cerebral ischemia/reperfusion via targeting IRF9 both in vivo and in vitro

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Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting autophagy through miRNA-132-3p/ATG12 signal axis

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MiR-342-5p protects neurons from cerebral ischemia induced-apoptosis through regulation of Akt/NF-KB pathways by targeting CCAR2

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MicroRNA-124-3p alleviates cerebral ischaemia-induced neuroaxonal damage by enhancing Nrep expression

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Therapeutic Potentials of MicroRNA-126 in Cerebral Ischemia

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MicroRNA152-3p Protects Against Ischemia/Reperfusion-Induced Bbb Destruction Possibly Targeting the MAP3K2/JNK/c-Jun Pathway

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Up-regulation of lncRNA NEAT1 in cerebral ischemic stroke promotes activation of astrocytes by modulation of miR-488-3p/RAC1

Haijian Zheng et al.

Summary: We aimed to investigate the role of lncRNA NEAT1 in activating astrocytes in a model of cerebral ischemia-reperfusion injury. A mouse model of cerebral ischemia-reperfusion injury was created, and shNEAT1 was transfected. Various assays were performed to detect changes in brain damage, inflammatory response, astrocyte activation, and the expression of NEAT1, miR-488-3p, and RAC1. Knockdown of NEAT1 was found to inhibit brain damage and suppress astrocyte activation. Furthermore, knockdown of NEAT1 increased the expression of miR-488-3p and decreased RAC1 expression. The study also demonstrated the involvement of miR-488-3p and RAC1 in astrocyte activation. Overexpression of NEAT1 in ischemic stroke promoted astrocyte activation through the modulation of miR-488-3p/RAC1. This study may have implications for the diagnosis and treatment of cerebral ischemia-reperfusion injury.

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Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway

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Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia

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OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression

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Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway

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Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury

Shengnan Li et al.

Summary: miR-181d is involved in neuronal apoptosis after cerebral ischemia/reperfusion injury by regulating DOCK4 expression. Suppression of miR-181d reduced apoptosis and oxidative stress in neuroblastoma cells treated with oxygen-glucose deficiency/reoxygenation, while overexpression of miR-181d increased these effects. Furthermore, overexpression of DOCK4 partially reversed the cell apoptosis and oxidative stress induced by miR-181d upregulation and oxygen-glucose deficiency/reoxygenation injury. The DOCK4 rs2074130 mutation was associated with lower DOCK4 levels in peripheral blood of ischemic stroke patients and higher susceptibility to ischemic stroke. These findings suggest that downregulating miR-181d may protect neurons from ischemic damage by targeting DOCK4, highlighting the miR-181d/DOCK4 axis as a potential therapeutic target for ischemic stroke.

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miR-181a targets PTEN to mediate the neuronal injury caused by oxygen-glucose deprivation and reoxygenation

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miR-671-5p Upregulation Attenuates Blood-Brain Barrier Disruption in the Ischemia Stroke Model Via the NF-kB/MMP-9 Signaling Pathway

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GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism

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miR-200b-3p antagomir inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model through regulating β-TrCP

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MiR-140-3p directly targets Tyro3 to regulate OGD/R-induced neuronal injury through the PI3K/Akt pathway

Yanli Zhang et al.

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Inhibition of miR-141-3p attenuates apoptosis of neural stem cells via targeting PBX1 to regulate PROK2 transcription in MCAO mice

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MicroRNA-32-3p facilitates cerebral ischemia/reperfusion injury through inhibiting Cab39/AMPK

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The combination of Alisma and Atractylodes ameliorates cerebral ischaemia/reperfusion injury by negatively regulating astrocyte-derived exosomal miR-200a-3p/141-3p by targeting SIRT1

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LncRNA XIST Exacerbates Oxygen-Glucose Deprivation/Reoxygenation-Induced Cerebral Injury Through the miR-25-3p/TRAF3 Axis

You Li et al.

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Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment

Dayalan Sampath et al.

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miR-101-3p improves neuronal morphology and attenuates neuronal apoptosis in ischemic stroke in young mice by downregulating HDAC9

Mengru Zhang et al.

Summary: The aim of this study was to investigate the role and mechanism of miR-101-3p activation in ischemic stroke (IS) in young mice and its relation to HDAC9. The expression of miR-101-3p and HDAC9 was measured in young mice subjected to transient middle cerebral artery occlusion (tMCAO) or sham surgery. Overexpression of miR-101-3p was found to improve cerebral infarction, neuronal morphology, and neuronal apoptosis in tMCAO young mice by inhibiting HDAC9 expression. These findings suggest that miR-101-3p and HDAC9 may be potential targets for IS therapy.

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Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis

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Summary: This study found that bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) carrying lncRNA KLF3-AS1 can alleviate cerebral ischemia/reperfusion-induced inflammatory injury by regulating Sirt1 deubiquitination. This finding is of great significance for understanding the therapeutic mechanisms of cerebral ischemia/reperfusion injury.

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Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria

Prashanth Gowda et al.

Summary: Alzheimer's disease is the most common cause of dementia, with a focus on mitochondrial dysfunction in neurons. Research is centered around mitochondrial miRNAs and their regulatory roles in mitochondrial and synaptic functions. However, more research is needed to confirm the specific locations and roles of individual mitochondrial miRNAs in the development of AD.

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Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease

Lining Su et al.

Summary: The study examined the expression patterns of mRNAs and miRNAs in exosomes derived from Alzheimer's disease (AD) and healthy mice, finding differential expression of 1320 mRNAs and 29 miRNAs between the two groups. Key genes such as Chi3l1 and Rhog were validated to be dysregulated in AD mice, along with miR-148a-5p and miR-27a-5p. GO and KEGG analysis helped determine the functions of the differentially expressed mRNAs and potential target genes of miRNAs. Through the ceRNA hypothesis, an integrated ceRNA network of circRNA-lncRNA-miRNA-mRNA was established, indicating the involvement of exosomal lncRNAs, mRNAs, circRNAs, and miRNAs in the progression of AD, potentially serving as biomarkers and therapeutic targets.

AGEING RESEARCH REVIEWS (2022)

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MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

Sen Liu et al.

Summary: Alzheimer's disease is a common neurodegenerative disease affecting millions worldwide. Recent studies have shown differential abundance and varieties of miRNAs in central and peripheral tissues of AD patients.

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Article Neurosciences

Alzheimer's Disease Diagnostics Using miRNA Biomarkers and Machine Learning

Amy Xu et al.

Summary: This study identifies potential biomarkers for Alzheimer's disease through analysis of dysregulation patterns of miRNA in blood. Machine learning models achieve high accuracy in diagnosing AD using these biomarkers.

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Article Biochemistry & Molecular Biology

Silencing of circCDC14A prevents cerebral ischemia-reperfusion injury via miR-23a-3p/CXCL12 axis

Huiyi Huo et al.

Summary: circCDC14A plays an important role in ischemic stroke by regulating the miR-23a-3p/CXCL12 axis, making it a potential therapeutic target for CI/R injury.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

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Article Cell Biology

MiR-361-3p alleviates cerebral ischemia-reperfusion injury by targeting NACC1 through the PINK1/Parkin pathway

Xihong Ye et al.

Summary: miR-361-3p improves ischemic brain injury by targeting NACC1 through the PINK1/Parkin pathway.

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Life of RISC: Formation, action, and degradation of RNA-induced silencing complex

Hiro-Oki Iwakawa et al.

Summary: Small RNAs regulate gene expression at the transcriptional and post-transcriptional levels by forming RISC complex and repressing target genes through mRNA cleavage, degradation, and translational repression. Various factors fine-tune RISC activity and stability, including guide-target RNA complementarity, recruitment of protein partners, and post-translational modifications of RISC itself.

MOLECULAR CELL (2022)

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Article Neurosciences

Overexpression of miR-149-5p Attenuates Cerebral Ischemia/Reperfusion (I/R) Injury by Targeting Notch2

Xiaoya Wang et al.

Summary: The study revealed that overexpression of miR-149-5p can protect the rat brain against I/R injury by regulating Notch2-mediated inflammation and apoptosis pathway.

NEUROMOLECULAR MEDICINE (2022)

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Article Neurosciences

Upregulation of miR-489-3p Attenuates Cerebral Ischemia/Reperfusion Injury by Targeting Histone Deacetylase 2 (HDAC2)

Tianxia Jia et al.

Summary: miR-489-3p attenuates cerebral I/R injury by negatively regulating HDAC2.

NEUROSCIENCE (2022)

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Article Neurosciences

Interfering TUG1 Attenuates Cerebrovascular Endothelial Apoptosis and Inflammatory injury After Cerebral Ischemia/Reperfusion via TUG1/miR-410/FOXO3 ceRNA Axis

Zhirong He et al.

Summary: The study showed that upregulation of TUG1 in cerebral ischemia/reperfusion and oxygen-glucose deprivation/reoxygenation-induced cells regulated inflammation and apoptosis through the miR-410/FOXO3 axis.

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Article Physiology

MiR-10b-3p alleviates cerebral ischemia/reperfusion injury by targeting Kruppel-like factor 5 (KLF5)

Ke Sun et al.

Summary: This study found that miR-10b-3p exerts neuroprotective effects by targeting KLF5, reducing neurological deficits, infarct volume, brain water content, inflammatory factors expression, and neuronal apoptosis in ischemic stroke rats and OGD/R-induced PC12 cells.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2022)

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Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant

Taylor E. Branyan et al.

Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.

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Article Cell Biology

Upregulation of miR-499a-5p Decreases Cerebral Ischemia/Reperfusion Injury by Targeting PDCD4

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Summary: MiR-499a-5p is downregulated in ischemic stroke patients, and overexpression can reduce cell apoptosis, mainly through inhibiting PDCD4-mediated apoptosis to exert neuroprotective effects.

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Review Biochemistry & Molecular Biology

Epigenetic regulation of human non-coding RNA gene transcription

Marco Morselli et al.

Summary: Recent investigations have revealed hidden layers of gene regulation in human cells, with a focus on the non-protein-coding transcriptome. This review highlights the relatively little attention given to the epigenetic regulation of non-protein-coding RNA genes, and suggests that further investigation could lead to a better understanding of the entire human epigenomic network.

BIOCHEMICAL SOCIETY TRANSACTIONS (2022)

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Article Biochemistry & Molecular Biology

MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke

Yamei Li et al.

Summary: This study found that miR-203a-3p and miR-153-3p confer neuroprotective effects against ischemic stroke by inhibiting the SRC-dependent MAPK signaling pathway in vivo and in vitro. These microRNAs can alleviate cognitive deficits, apoptosis, oxidative stress, and inflammation.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Review Biochemistry & Molecular Biology

Circulating microRNAs in Medicine

Tetiana Pozniak et al.

Summary: Circulating microRNAs serve as sensitive biomarkers for diagnosing and treating various diseases, playing a significant role in monitoring diseases and evaluating treatment outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Artificial Intelligence Predictor for Alzheimer's Disease Trained on Blood Transcriptome: The Role of Oxidative Stress

Luigi Chiricosta et al.

Summary: This study developed a machine learning model based on blood transcriptome data for the non-invasive diagnosis of AD. Support vector machines, neural networks, and logistic regression methods were all able to achieve high accuracy in predicting AD. Gene ontology analysis showed that mitochondrial translation biological process was the most interesting, and examination of KEGG pathways indicated that the accumulation of beta-amyloid may trigger oxidative stress, which is a key feature in predicting AD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

FTX Attenuates Cerebral Ischemia-Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress via miR-186-5p/MDM4 Pathway

Wenhua Wang et al.

Summary: This study found that the lncRNA FTX can improve cerebral ischemia-reperfusion injury by regulating the miR-186-5p/MDM4 pathway, providing a new therapeutic strategy for stroke impairment treatment.

NEUROTOXICITY RESEARCH (2022)

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Article Biology

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

Brianna Bibel et al.

Summary: Argonaute (Ago) proteins play a crucial role in post-transcriptional gene regulation through RNA interference. Phosphorylation by CK1 alpha can alleviate miRNA-mediated repression by promoting target release, allowing Ago to target additional mRNAs.

ELIFE (2022)

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Review Neurosciences

Non-coding RNAs in the regulation of blood-brain barrier functions in central nervous system disorders

Ping Sun et al.

Summary: The blood-brain barrier (BBB) is crucial for controlling exchanges between blood and brain, with damage being a common feature of CNS disorders. Non-coding RNAs play an important regulatory role in these diseases, serving as potential diagnostic and prognostic markers.

FLUIDS AND BARRIERS OF THE CNS (2022)

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Article Neurosciences

RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition

Weijian Fan et al.

EXPERIMENTAL NEUROLOGY (2022)

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Article Cell Biology

LncRNA PEG11as silencing sponges miR-874-3p to alleviate cerebral ischemia stroke via regulating autophagy in vivo and in vitro

Xiamin Hu et al.

Aging-US (2022)

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Review Oncology

Circulating microRNAs: Challenges with their use as liquid biopsy biomarkers

Satoko Takizawa et al.

Summary: Circulating miRNA is a potential biomarker for liquid biopsy, but its levels are influenced by various factors. Research into these factors is ongoing, but more evidence is needed to draw definite conclusions.

CANCER BIOMARKERS (2022)

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Article Cell Biology

The protective effects of lncRNA ZFAS1/miR-421-3p/MEF2C axis on cerebral ischemia-reperfusion injury

Jiangqi Xu et al.

Summary: The present study investigated the protective mechanism of ZFAS1 in cerebral ischemia-reperfusion injury. The up-regulation of ZFAS1 was found to improve cell damage, inhibit apoptosis, and reduce inflammation. MiR-421-3p was identified as a target miRNA of ZFAS1 and its up-regulation attenuated the protective effect of ZFAS1 overexpression. MEF2C, the downstream target gene of miR-421-3p, reversed the enhanced cell damage caused by miR-421-3p mimic when overexpressed. In vivo experiments confirmed the protective effects of ZFAS1 overexpression in reducing brain tissue infarction, apoptosis, and gene regulation.

CELL CYCLE (2022)

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Review Biochemistry & Molecular Biology

MicroRNA-Based Diagnosis and Therapy

Phuong T. B. Ho et al.

Summary: MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression and hold promise as biomarkers for diagnosis and prognosis of diseases. This review discusses the intracellular and extracellular trafficking of miRNAs, their role as potential biomarkers, measurement methods, available panels for clinical use, and their potential as therapeutics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

Exosomes Released from Bone-Marrow Stem Cells Ameliorate Hippocampal Neuronal Injury Through transferring miR-455-3p

Chao Gan et al.

Summary: In this study, we discovered that exosomes derived from bone marrow MSCs containing miR-455-3p alleviate hippocampal neuronal injury in MCAO/R-treated mice and N2a cell injury induced by OGD/R by targeting PDCD7.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2022)

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Article Endocrinology & Metabolism

LncRNA SNHG14 is beneficial to oxygen glucose deprivation/reoxygenation-induced neuro-2a cell injury via mir-98-5p sequestration-caused BCL2L13 upregulation

Gaolian Zhang et al.

Summary: SNHG14 knockdown alleviated cell apoptosis, ER stress, inflammation, and oxidative stress induced by cerebral ischemia/reperfusion injury by regulating miR-98-5p and BCL2L13 expression.

METABOLIC BRAIN DISEASE (2022)

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Article Neurosciences

miR-383-5p Regulated by the Transcription Factor CTCF Affects Neuronal Impairment in Cerebral Ischemia by Mediating Deacetylase HDAC9 Activity

Jun Shen et al.

Summary: This study reveals the role of the CTCF/miR-383-5p/HDAC9 pathway in ischemic brain injury and further confirms its impact on neuronal apoptosis and brain damage.

MOLECULAR NEUROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

MiR-182 Inhibition Protects Against Experimental Stroke in vivo and Mitigates Astrocyte Injury and Inflammation in vitro via Modulation of Cortactin Activity

Qasim M. Alhadidi et al.

Summary: Ischemic stroke is a devastating cerebrovascular disease, and research suggests that miR-182 plays a crucial role in stroke injury and recovery. Inhibition of miR-182 has been found to protect mitochondrial structure, mitigate neuroinflammation, and reduce cell death.

NEUROCHEMICAL RESEARCH (2022)

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Review Medicine, General & Internal

A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics

Rima Hajjo et al.

Summary: Alzheimer's disease is a complex neurodegenerative disease without a cure. Epigenetic factors have been found to be implicated in the disease pathogenesis and may serve as promising diagnostic biomarkers. Network biology approaches are seen as effective tools for studying the disease and discovering new treatments.

DIAGNOSTICS (2022)

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Article Medicine, General & Internal

Serum Expression Levels of Certain miRNAs in Predicting Diagnosis, Prognosis, and Response to Chemotherapy in Malignant Pleural Mesothelioma

Muzaffer Metintas et al.

Summary: miRNAs may have potential clinical value in the diagnosis and prognosis of patients with MPM.

BALKAN MEDICAL JOURNAL (2022)

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Review Neurosciences

miRNA Involvement in Cerebral Ischemia-Reperfusion Injury

Maria-Adriana Neag et al.

Summary: Micro RNAs (miRNAs) play a crucial role in regulating protein synthesis during cerebral ischemia-reperfusion injuries. Understanding the signaling and modulating effects of miRNAs in this context could lead to the development of neuroprotective agents.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Biotechnology & Applied Microbiology

MicroRNA-489-3p aggravates neuronal apoptosis and oxidative stress after cerebral ischemia-reperfusion injury

LiGuo Song et al.

Summary: This study found that elevated miR-489-3p aggravates neuronal apoptosis and oxidative stress induced by cerebral ischemia-reperfusion injury (CIRI) through targeting SIRT1. Down-regulating miR-489-3p or up-regulating SIRT1 can ameliorate the neural functional damage caused by CIRI.

BIOENGINEERED (2022)

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Review Cell Biology

An integrative machine-learning meta-analysis of high-throughput omics data identifies age-specific hallmarks of Alzheimer's disease

Maxim N. Shokhirev et al.

Summary: Alzheimer's disease, an incurable age-related brain disorder, was studied through the analysis of genes, proteins, and microRNAs. The results showed that factors such as cell death, cellular senescence, energy metabolism, genomic integrity, and glia were associated with the disease. These factors exhibited unique characteristics in different age groups.

AGEING RESEARCH REVIEWS (2022)

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Article Substance Abuse

MicroRNA-150-5p is upregulated in the brain microvasculature during prenatal alcohol exposure and inhibits the angiogenic factor Vezf1

Gabriela Perales et al.

Summary: This study found that the regulation of Vezf1 by miR-150-5p leads to altered endothelial cell function during prenatal alcohol exposure. These changes may contribute to the neurocognitive deficits seen in patients with FASD.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Physiological and Pathological Remodeling of Cerebral Microvessels

Pavel P. Tregub et al.

Summary: The remodeling of cerebral microvessels has a significant impact on brain plasticity and neurodegenerative diseases. Abnormal neoangiogenesis and microvascular regression are associated with blood-brain barrier breakdown, neuroinflammation, and dysfunction of the neurovascular unit. This review summarizes the mechanisms of blood vessel regression and pruning, and discusses novel approaches to modulating cerebral remodeling and preventing aberrant microvascular activity in chronic neurodegeneration.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Long non-coding RNA RPL34-AS1 ameliorates oxygen-glucose deprivation-induced neuronal injury via modulating miR-223-3p/IGF1R axis

Xin-Ya Wei et al.

Summary: In this study, it was found that lncRNA RPL34-AS1 attenuated ischemic brain injury by mediating the miR-223-3p/IGF1R axis.

HUMAN CELL (2022)

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Article Multidisciplinary Sciences

Rapid and accurate quantification of isomiRs by RT-qPCR

Sandra Franco et al.

Summary: This study presents a simple reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay for quantifying the miR-100-5p_iso_3p:-2 variant. The assay was validated in 57 plasma samples and showed high concordance with high-throughput RNA sequencing results. The method can be easily adapted for quantifying other identified isomiRs, providing greater resolution and accuracy compared to using canonical sequences.

SCIENTIFIC REPORTS (2022)

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Review Immunology

A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury

Kailin Yang et al.

Summary: Cerebral infarction/ischemia-reperfusion injury, which has the highest mortality and disability rate among cardiovascular diseases, is associated with immune responses and inflammatory cascade reactions. Noncoding RNAs (ncRNAs) play important roles in regulating the dysfunction of various cell subsets in the neurovascular unit after cerebral infarction/ischemia-reperfusion injury, and they have the potential to be biomarkers and therapeutic targets for this disease.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Emerging Role of miR-21-5p in Neuron-Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer's Disease

Goncalo Garcia et al.

Summary: MiR-21 is found to be overexpressed in glial cells and exosomes in Alzheimer's disease (AD), and also shows high expression in the cerebrospinal fluid (CSF) with potential discriminatory ability. MiR-21 elevation is observed in microglia, neurons, and astrocytes in AD patients, and may be associated with the repression of its target, PPAR alpha.

CELLS (2022)

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Article Biochemistry & Molecular Biology

MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1

Hai Zhou et al.

Summary: The study demonstrates that exosomal miR-145 derived from MSCs can attenuate cerebral ischemia/reperfusion injury by downregulating FOXO1, leading to a shift in microglial polarization and inhibition of apoptosis, cell cycle arrest, and oxidative stress. Exosomal miR-145 may serve as a potential therapeutic approach for treating cerebral ischemia/reperfusion injury.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Medicine, General & Internal

MiR-494-3p Upregulation Exacerbates Cerebral Ischemia Injury by Targeting Bhlhe40

Lingjiang Sun et al.

Summary: This study found that miR-494-3p exacerbates cell apoptosis and reactive oxygen species (ROS) production in brain injury and neuronal injury by regulating the expression of Bhlhe40 protein during cerebral ischemia/reperfusion (I/R).

YONSEI MEDICAL JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Two-step formulation of magnetic nanoprobes for microRNA capture

Iveta Vilimova et al.

Summary: This study proposes a rapid and efficient protocol for the generation of magnetic nanoprobes to capture miR-155, aiming to increase its concentration. The nanoprobes were formulated by functionalizing the surface of superparamagnetic iron oxide nanoparticles with a miR sequence complementary to the target miR-155. The affinity of the nanoprobes to the target miR was demonstrated, and their stability after incubation in serum was confirmed.

RSC ADVANCES (2022)

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Article Medicine, Research & Experimental

Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway

Quande Dai et al.

Summary: In this study, it was found that circRNA HECTD1 plays a crucial role in cerebral ischemia/reperfusion injury by regulating the expression of miR-133b and TRAF3, affecting neuronal cell death and brain infarction volume.

LIFE SCIENCES (2021)

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Review Medical Laboratory Technology

Circulating microRNAs: Biomarkers of disease

Yudong Wu et al.

Summary: MicroRNAs, approximately 20-24 nucleotides in length, are considered reliable diagnostic and prognostic biomarkers for various diseases due to their reflection of disease progression and drug resistance. They play a crucial role in the diagnosis, prognosis, and treatment response prediction of diseases, potentially improving cure rates.

CLINICA CHIMICA ACTA (2021)

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Review Neurosciences

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer's and Parkinson's Diseases

Sonia Mayo et al.

Summary: Research has shown that microRNAs and DNA methylation may serve as potential diagnostic biomarkers in Alzheimer's disease and Parkinson's disease patients. Meanwhile, certain proteins show differential expression levels in the plasma of disease patients and healthy individuals. Despite the identification of specific biomarkers, clinical validation remains a common issue.

CURRENT NEUROPHARMACOLOGY (2021)

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Review Chemistry, Medicinal

Potential Epigenetic Targets for Combating Alzheimer's Disease

Dheeraj Pandey et al.

Summary: This article discusses the importance of epigenetics in Alzheimer's disease, suggesting that various epigenetic targets may provide new insights into potential therapeutic approaches for AD.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

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Article Cell Biology

Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor κB p65 signaling

Feng Kuai et al.

Aging-US (2021)

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Article Endocrinology & Metabolism

MicroRNA-32-5p attenuates cerebral ischemia/reperfusion injuries by modulating the phosphatase and tensin homologous protein

Yao Wang et al.

Summary: This study demonstrated that miR-32-5p has neuroprotective effects against brain I/R injuries by modulating the PTEN/PI3K/AKT signaling pathway. Overexpression of miR-32-5p reduced brain damages in rats induced by MCAO/R, and PTEN was identified as a target of miR-32-5p. Additionally, miR-32-5p was able to activate PI3K/AKT signaling by inhibiting PTEN.

METABOLIC BRAIN DISEASE (2021)

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Article Neurosciences

The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives

Hannah Walgrave et al.

Summary: Researchers review the regulation of microRNAs in the pathophysiology of Alzheimer's disease and critically discuss the potential for developing microRNA-based therapeutics using these insights.

MOLECULAR NEURODEGENERATION (2021)

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Article Toxicology

MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression

Y. Xiao et al.

Summary: miR-26b-5p plays a protective role in cerebral ischemia-reperfusion injury by regulating KLF10 expression and related signaling pathways, affecting cell apoptosis, oxidative stress, inflammatory factors, etc.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Review Biochemistry & Molecular Biology

Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease

Chun-Hung Chang et al.

Summary: This study investigated the application of machine learning and novel biomarkers in the diagnosis of Alzheimer's disease (AD). In addition to traditional Aβ and tau-related biomarkers, biomarkers related to neuronal injury, synaptic dysfunction, and neuroinflammation were explored. Machine learning combined with novel biomarkers and multiple variables may improve the sensitivity and specificity in diagnosing AD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Neurosciences

Down-Regulation of miR-181a-5p Prevents Cerebral Ischemic Injury by Upregulating En2 and Activating Wnt/β-catenin Pathway

Xiaoming Song et al.

Summary: The study demonstrates the critical role of miR-181a-5p in cerebral ischemic injury by regulating En2 and the Wnt/β-catenin pathway to alleviate brain damage.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Article Medicine, Research & Experimental

Knockdown of long non-coding RNA RMRP protects cerebral ischemia-reperfusion injury via the microRNA-613/ATG3 axis and the JAK2/STAT3 pathway

Li Wei et al.

Summary: This study investigated the role of lncRNA RMRP in cerebral I/R injury, revealing that RMRP upregulates ATG3 expression through miR-613 and inhibits the JAK2/STAT3 pathway activation, ultimately promoting cerebral I/R injury in mice.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

LncRNA SNHG15 Knockdown Protects Against OGD/R-Induced Neuron Injury by Downregulating TP53INP1 Expression via Binding to miR-455-3p

Yun Fan et al.

Summary: This study revealed that SNHG15 contributes to oxygen-glucose deprivation and reoxygenation-induced neuron injury by regulating the miR-455-3p/TP53INP1 axis, suggesting a potential novel therapeutic target for ischemic stroke.

NEUROCHEMICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis

Guanglin Zhang et al.

Summary: Ischemic stroke is a major cause of disability worldwide and long noncoding RNAs (lncRNAs) play crucial roles in its pathogenesis. This study found that SNHG14 regulates ischemic brain injury through the miR-199b/AQP4 axis, inhibiting inflammation and oxidative stress.

NEUROCHEMICAL RESEARCH (2021)

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Article Clinical Neurology

Neurodegeneration and epigenetics: A review

P. Ghosh et al.

NEUROLOGIA (2021)

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Article Neurosciences

Inhibition of microRNA-143-3p Attenuates Cerebral Ischemia/Reperfusion Injury by Targeting FSTL1

Shunda Wang et al.

Summary: The study found that miR-143-3p expression is significantly upregulated during cerebral I/R injury, and inhibition of miR-143-3p can protect against neurological deficits, reduce infarct volume, enhance cell viability, and decrease cell apoptosis. This protective effect may be achieved through regulating the expression of FSTL1 protein.

NEUROMOLECULAR MEDICINE (2021)

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Article Cell & Tissue Engineering

Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction

Bo Yang et al.

Summary: The study revealed that circTTC3 plays a role in regulating CIR injury and NSCs, with its depletion shown to reduce cerebral infarction and promote NSC proliferation. CircTTC3 was found to sponge miR-372-3p and regulate TLR4 expression, suggesting potential targets for stroke treatment.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis

Yamei Zhang et al.

Summary: The study indicates that ASC-EV-derived miR-22-3p attenuates brain ischemic injury by inhibiting the effects of KDM6B on the BMP2/BMF axis.

STEM CELL RESEARCH & THERAPY (2021)

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Review Biochemistry & Molecular Biology

Epigenetics of Alzheimer's Disease

Matea Nikolac Perkovic et al.

Summary: Validated biomarkers for accurately diagnosing Alzheimer's disease (AD) are currently lacking, but epigenetic modifications have been identified as important factors in the pathogenesis of AD. DNA methylation, hydroxymethylation, histone modifications, and non-coding RNA regulation play critical roles in the development of AD, while mitochondrial DNA may serve as a potential biomarker for AD.

BIOMOLECULES (2021)

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Article Cell Biology

MiR-27a-3p suppresses cerebral ischemia-reperfusion injury by targeting FOXO1

Wenyu Li et al.

Summary: The study found that miR-27a-3p can suppress cerebral ischemia-reperfusion injury by targeting FOXO1. In vitro experiments showed that OGD induced apoptosis and oxidative stress in HT22 cells, along with G1 arrest mediated by FOXO1/p27 Kip1 signaling. MiR-27a-3p mimics reversed these effects, and in vivo studies using a rat model also showed alleviation of CI/R symptoms with miR-27a-3p agomir treatment.

AGING-US (2021)

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Article Cell Biology

MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1

Yuanyuan Shi et al.

Summary: miR-532-5p plays a crucial role in CI/RI, with its overexpression reducing apoptosis, reactive oxygen species, and inflammation levels, and alleviating the extent of cerebral ischemia-reperfusion injury by targeting CXCL1. Methylation inhibitors can restore the expression of miR-532-5p in exposed cells.

AGING-US (2021)

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Article Cell Biology

Circular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis

Zhenduo Zhang et al.

Summary: This study revealed the crucial role of circ_HECTD1 in modulating cell damage induced by cerebral ischemia through the regulation of the miR-27a-3p/FSTL1 axis, providing a novel potential therapeutic target for cerebral infarction treatment.

CELL CYCLE (2021)

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Review Chemistry, Analytical

Recent Progress in Nanomaterials Modified Electrochemical Biosensors for the Detection of MicroRNA

Sze Shin Low et al.

Summary: miRNAs, as important non-coding RNAs in the human body, play crucial regulatory roles and are closely related to diseases. The use of electrochemical biosensors provides a fast and accurate detection method for miRNAs, offering new avenues for biological analysis and early disease diagnosis.

MICROMACHINES (2021)

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Article Clinical Neurology

miR-666-3p Mediates the Protective Effects of Mesenchymal Stem Cell-derived Exosomes Against Oxygen-glucose Deprivation and Reoxygenation-induced Cell Injury in Brain Microvascular Endothelial Cells via Mitogen-activated Protein Kinase Pathway

Li-yun Kong et al.

Summary: The study demonstrates that MSC-derived exosomes restore the expression of key miRNAs, such as rno-miR-666-3p, in OGD/R-exposed BMECs, which helps to suppress inflammation and apoptosis, providing a protective effect.

CURRENT NEUROVASCULAR RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA NORAD protects against cerebral ischemia/reperfusion injury induced brain damage, cell apoptosis, oxidative stress and inflammation by regulating miR-30a-5p/YWHAG

Xinyu Zhou et al.

Summary: LncRNA NORAD exerts protective effects in OGD/R-induced neural injury by binding miR-30a-5p to upregulate YWHAG expression, reducing cell apoptosis and alleviating oxidative stress and inflammation.

BIOENGINEERED (2021)

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Review Pharmacology & Pharmacy

Epigenetic regulation in Alzheimer's disease: is it a potential therapeutic target?

Fabio Coppede

Summary: Alzheimer's disease is the primary form of dementia in the elderly, with changes in DNA methylation and post-translational modifications of histone tails likely contributing to the disease onset and progression. Targeting these modifications has shown potential to attenuate AD features, but there are concerns about the safety and tolerability of long-term treatment.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

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Article Cell Biology

Foxo1-induced miR-92b down-regulation promotes blood-brain barrier damage after ischaemic stroke by targeting NOX4

Jian Shen et al.

Summary: The study showed that miR-92b influences the BBB damage after ischaemic stroke by regulating NOX4 expression, while Foxo1 is involved in this process by controlling the expression of miR-92b.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

CEBPA-AS1 Knockdown Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Neuron Cell Damage by the MicroRNA 24-3p/BOK Axis

Guangfu Di et al.

Summary: The downregulation of CEBPA-AS1 protects against OGD/R-induced cell injury by targeting the miR-24-3p/BOK axis, reducing oxidative stress and apoptosis.

MOLECULAR AND CELLULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis

Heng-Sheng Zhang et al.

Summary: The study revealed that Gastrodin (GAS) significantly improved neurological scores and reduced cerebral infarction area in rats by modulating the lncRNA NEAT1/miR-22-3p axis. GAS inhibited pyroptosis by downregulating NLRP3, inflammatory factors (IL-1 beta, IL-18), and cleaved caspase-1. Furthermore, GAS attenuated I/R-induced inflammation in neuronal cells through the modulation of the lncRNA NEAT1/miR-22-3p axis.

NEUROCHEMICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Astrocyte-Endotheliocyte Axis in the Regulation of the Blood-Brain Barrier

Augustas Pivoriunas et al.

Summary: The evolution of the blood-brain barrier is closely related to the centralization of the nervous system. Different animals have different ways of forming barriers, with the vertebrates having an endothelial barrier secured by tight and adherent junctions. Astrocytes communicate with endothelial cells through secretion, regulating the integrity of the blood-brain barrier.

NEUROCHEMICAL RESEARCH (2021)

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Article Neurosciences

Increased miR-187-3p expression after cerebral ischemia/reperfusion induces apoptosis via initiation of endoplasmic reticulum stress

Zhenkui Ren et al.

Summary: The study revealed that miR-187-3p plays a regulatory role in I/R injury by modulating the seipin-mediated ERS pathway. The increase in miR-187-3p and decrease in seipin expression were closely associated with I/R-induced ERS.

NEUROSCIENCE LETTERS (2021)

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Article Neurosciences

MiR-363-3p attenuates neonatal hypoxic-ischemia encephalopathy by targeting DUSP5

Ying Jia et al.

Summary: The study indicates that miR-363-3p can attenuate neonatal hypoxic-ischemia encephalopathy (HIE) by targeting DUSP5.

NEUROSCIENCE RESEARCH (2021)

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Review Neurosciences

Epigenetics in blood-brain barrier disruption

Stephanie A. Ihezie et al.

Summary: The vessels of the central nervous system have unique barrier properties that protect the brain and maintain homeostasis. Blood-brain barrier leakage is a serious secondary injury in various CNS disorders, with currently no specific drugs available. Advances in epigenetics hold great potential for developing novel therapeutic strategies to repair a disrupted blood-brain barrier.

FLUIDS AND BARRIERS OF THE CNS (2021)

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Article Neurosciences

Long noncoding RNA SOX2OT silencing alleviates cerebral ischemia-reperfusion injury via miR-135a-5p-mediated NR3C2 inhibition

Chao Wang et al.

Summary: This study investigated the role of SOX2 overlapping transcript (SOX2OT) in cerebral ischemia-reperfusion injury (CIRI) and found that silencing SOX2OT attenuated CIRI via regulation of the miR-135a-5p/NR3C2 axis, suggesting a potential novel therapeutic target for CIRI.

BRAIN RESEARCH BULLETIN (2021)

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Article Biology

An updated overview and classification of bioinformatics tools for MicroRNA analysis, which one to choose?

Sedigheh Sadat Mortazavi et al.

Summary: MicroRNAs are small endogenous non-coding RNAs that play crucial regulatory roles in biological processes through translational repression or mRNA degradation. The importance of miRNAs has led to the development of multiple databases, each with specific parameters and characteristics for researchers to benefit from. Understanding the classification and information contained in these databases is essential for scientists to quickly find suitable bioinformatics tools and relevant information.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Article Developmental Biology

High gestational folic acid supplementation prevents hypoxia-ischemia-induced caspase-3 augmenting without changing synapsin and H3 methylation levels in the rat hippocampus

Bruna Ferrary Deniz et al.

Summary: Perinatal asphyxia can have long-lasting effects on brain development in newborns, with recent research suggesting that folic acid supplementation may play a role in mitigating these effects. Neonatal hypoxia-ischemia can lead to cell death and altered synaptic protein expression in the hippocampus of rats, with histone modifications potentially contributing to these pathological changes.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2021)

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Article Immunology

miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway

Feng Zhou et al.

Summary: The study found that miR-19a/b-3p promotes inflammatory responses during cerebral ischemia/reperfusion injury by regulating the SIRT1/FoxO3/SPHK1 axis, providing a new therapeutic target for stroke treatment.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Endocrinology & Metabolism

Long non-coding RNA Gm11974 aggravates oxygen-glucose deprivation-induced injury via miR-122-5p/SEMA3A axis in ischaemic stroke

Ling Yang et al.

Summary: In ischaemic stroke, up-regulation of Gm11974 promotes neuronal injury, while the negative regulation of miR-122-5p and SEMA3A can alleviate cellular damage. Lowering Gm11974 levels contributes to improving neuronal injury in stroke patients.

METABOLIC BRAIN DISEASE (2021)

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Article Multidisciplinary Sciences

Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum

Shenglin Cai et al.

Summary: The study presents a new sensing platform for miRNA detection, offering high sensitivity and specificity directly in human serum, and demonstrating monitoring of miR-141-3p and miR-375-3p in various stages of prostate cancer.

NATURE COMMUNICATIONS (2021)

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Article Clinical Neurology

Prediction of differentially expressed microRNAs in blood as potential biomarkers for Alzheimer's disease by meta-analysis and adaptive boosting ensemble learning

Sze Chung Yuen et al.

Summary: This study identified 28 potential AD biomarkers in blood using a combination of meta-analysis and ABMDA ensemble learning. The identified DEmiRNAs were significantly related to neuroinflammation, while ABMDA-identified DEmiRNAs were associated with neuronal cell cycle re-entry.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Review Oncology

Circulating MicroRNAs in Gastrointestinal Cancer

Masahisa Ohtsuka et al.

Summary: MicroRNAs (miRNAs) show potential as noninvasive biomarkers for gastrointestinal cancer (GIC) due to their stability in blood and association with GIC status. Research on miRNAs is crucial for early detection and treatment improvement in GIC patients.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Splice and Dice: Intronic microRNAs, Splicing and Cancer

Alex C. H. Wong et al.

Summary: Introns, which make up only a quarter of the human genome, host about 60% of all known microRNAs. The co-regulation of intronic microRNAs with their host genes plays a crucial role in cancer, yet their significance in cancer pathogenesis is often underestimated.

BIOMEDICINES (2021)

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Article Neurosciences

Remote ischaemic perconditioning reduces the infarct volume and improves the neurological function of acute ischaemic stroke partially through the miR-153-5p/TLR4/p65/IκBα signalling pathway

Hao Zha et al.

Summary: The study revealed that remote ischemic perconditioning (RIPerC) can partially inhibit damage caused by cerebral ischemia through the miR-153-5p/TLR4/p65/I kappa B alpha signaling pathway. Positive effects were observed in both in vivo studies using a mouse model of cerebral ischemia and in vitro cell experiments, highlighting the potential therapeutic benefits of RIPerC in ischemic stroke.

FOLIA NEUROPATHOLOGICA (2021)

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Article Neurosciences

Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation

Hao Zhang et al.

Summary: Research has shown that lncRNA-PVT1 plays a crucial role in ischemic stroke by regulating the expression of miR-30c-5p and Rock2, ultimately activating the MAPK signaling pathway and exacerbating cerebral ischemia/reperfusion injury.

MOLECULAR NEUROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Argonaute proteins: structures and their endonuclease activity

Shujuan Jin et al.

Summary: Argonaute proteins, highly conserved and widely expressed, play critical roles in small RNA biogenesis and gene silencing through small RNA or DNA-mediated pathways. They act as nucleic-acid-guided endonucleases to cleave target genes, leading to translational silencing by recruiting additional silencing proteins.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Clinical Neurology

Biliverdin Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating the miR-27a-3p/Rgs1 Axis

Junjie Li et al.

Summary: The study demonstrated that biliverdin protects against cerebral ischemia/reperfusion injury by regulating the miR-27a-3p/Rgs1 axis to inhibit inflammation and apoptosis.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Article Clinical Neurology

MicroRNA-488-3p Regulates Neuronal Cell Death in Cerebral Ischemic Stroke Through Vacuolar Protein Sorting 4B (VPS4B)

Li Zhou et al.

Summary: The study found that miR-488-3p reduces neuronal death and inhibits brain ischemic injury by targeting VPS4B, providing a new therapeutic target for the treatment of ischemic stroke.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Article Developmental Biology

miR-325-3p Protects Neurons from Oxygen-Glucose Deprivation and Reoxygenation Injury via Inhibition of RIP3

Song Yi et al.

Summary: The study revealed that miR-325-3p targets RIP3 to inhibit the MAPK signaling pathway activity, thereby protecting neurons from OGD/R-induced injury. This finding unveils a novel neuroprotective mechanism.

DEVELOPMENTAL NEUROSCIENCE (2021)

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Article Endocrinology & Metabolism

miR-98 reduces endothelial dysfunction by protecting blood-brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model

David L. Bernstein et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

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Review Biochemistry & Molecular Biology

Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies

Guillaume Gines et al.

MOLECULAR ASPECTS OF MEDICINE (2020)

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Article Biochemical Research Methods

Rainbowarray Microsphere-Based Gene Detection Assay

Ying Xu et al.

SLAS TECHNOLOGY (2020)

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Article Cell Biology

Identifying lncRNA-miRNA-mRNA networks to investigate Alzheimer's disease pathogenesis and therapy strategy

Nana Ma et al.

AGING-US (2020)

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Article Biochemical Research Methods

Physical and chemical template-blocking strategies in the exponential amplification reaction of circulating microRNAs

Michael P. Trinh et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor

Umesh Bhattarai et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

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Article Pharmacology & Pharmacy

Inhibition of microRNA-199a-5p ameliorates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO-1 signalling

Feng Li et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

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Article Pharmacology & Pharmacy

Inhibition of microRNA-148b-3p alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

Yin Du et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

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Article Neurosciences

Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

Ji Liang et al.

EXPERIMENTAL NEUROLOGY (2020)

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Article Biochemical Research Methods

MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway

Bing Li et al.

MOLECULAR AND CELLULAR PROBES (2020)

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Article Clinical Neurology

MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion

Jiaji Pan et al.

STROKE (2020)

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Article Chemistry, Analytical

Direct and sensitive detection of circulating miRNA in human serum by ligase-mediated amplification

Hei-Nga Chan et al.

TALANTA (2020)

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Article Multidisciplinary Sciences

MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes

Heng Hu et al.

SCIENTIFIC REPORTS (2020)

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Article Clinical Neurology

MiR-142-3p Attenuates Oxygen Glucose Deprivation/Reoxygenation-Induced Injury by Targeting FBXO3 in Human Neuroblastoma SH-SY5Y Cells

Jin Li et al.

WORLD NEUROSURGERY (2020)

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Article Biotechnology & Applied Microbiology

Circular RNA cZNF292 silence alleviates OGD/R-induced injury through up-regulation of miR-22 in rat neural stem cells (NSCs) (Publication with Expression of Concern. See vol. 50, pg. 223, 2022)

Yaqin Cao et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

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Review Neurosciences

MicroRNAs in the Blood-Brain Barrier in Hypoxic-Ischemic Brain Injury

Guofang Shen et al.

CURRENT NEUROPHARMACOLOGY (2020)

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Article Clinical Neurology

MiR-485-5p Promotes Neuron Survival through Mediating Rac1/Notch2 Signaling Pathway after Cerebral Ischemia/Reperfusion

Xuan Chen et al.

CURRENT NEUROVASCULAR RESEARCH (2020)

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Article Neurosciences

MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression

Zhihao Chen et al.

EXPERIMENTAL NEUROLOGY (2020)

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Article Medicine, Research & Experimental

MiR-370 accelerated cerebral ischemia reperfusion injury via targeting SIRT6 and regulating Nrf2/ARE signal pathway

Zhong-Fan Ruan et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2020)

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Article Pharmacology & Pharmacy

miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2

Zhe Peng et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Oncology

Therapeutic inhibition of microRNA-21 (miR-21) using locked-nucleic acid (LNA)-anti-miR and its effects on the biological behaviors of melanoma cancer cells in preclinical studies

Shaghayegh Haghjooy Javanmard et al.

CANCER CELL INTERNATIONAL (2020)

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Article Cell Biology

KCNQ1OT1 Exacerbates Ischemia-Reperfusion Injury Through Targeted Inhibition of miR-140-3P

Ming Yi et al.

INFLAMMATION (2020)

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Article Immunology

MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-kappa B signaling via targeting TRIM8

Xiajing Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Neurosciences

Modeling blood-brain barrier pathology in cerebrovascular disease in vitro: current and future paradigms

Anuska Andjelkovic et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

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Article Neurosciences

Epigenetic Regulation of Ferroportin in Primary Cultures of the Rat Blood-Brain Barrier

Steinunn Sara Helgudottir et al.

MOLECULAR NEUROBIOLOGY (2020)

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Article Neurosciences

LncRNA H19 Aggravates Cerebral Ischemia/Reperfusion Injury by Functioning as a ceRNA for miR-19a-3p to Target PTEN

Ning Gao et al.

NEUROSCIENCE (2020)

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Article Physiology

MiR-92b-3p regulates oxygen and glucose deprivation-reperfusion-mediated apoptosis and inflammation by targeting TRAF3 in PC12 cells

Enyu Liu et al.

EXPERIMENTAL PHYSIOLOGY (2020)

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Article Biochemistry & Molecular Biology

MicroRNA-182 exacerbates blood-brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia

Tongshuai Zhang et al.

FASEB JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Inhibition ofmicroRNA-9-5p andmicroRNA-128-3p can inhibit ischemic stroke-related cell death in vitro and in vivo

Qi Yan et al.

IUBMB LIFE (2020)

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Article Neurosciences

Long Non-Coding KCNQ1OT1 Promotes Oxygen-Glucose- Deprivation/Reoxygenation-Induced Neurons Injury Through Regulating MIR-153-3p/FOXO3 Axis

Hua-Jun Wang et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

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Article Chemistry, Multidisciplinary

Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras

Heera K. Langner et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Review Cell Biology

RNA and Oxidative Stress in Alzheimer's Disease: Focus on microRNAs

Akihiko Nunomura et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Pathology

Neuroprotective effects of miR-30c on rats with cerebral ischemia/reperfusion injury by targeting SOX9

Min Zhang et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

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Article Immunology

microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation

Linbo Zheng et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Neurosciences

MiR-29a-3p Enhances the Viability of Rat Neuronal Cells that Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment Through Targeting TNFRSF1A and Regulating NF-κB Signaling Pathway

Xiao-Zeng Gao et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

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Article Medicine, Research & Experimental

Exosomes from MSCs overexpressing microRNA-223-3p attenuate cerebral ischemia through inhibiting microglial M1 polarization mediated inflammation

Yangmin Zhao et al.

LIFE SCIENCES (2020)

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Review Chemistry, Analytical

MicroRNAs in ovarian cancer and recent advances in the development of microRNA-based biosensors

Nahian Binte Aziz et al.

ANALYST (2020)

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Article Biology

Inhibition of miR-19a-3p decreases cerebral ischemia/reperfusion injury by targeting IGFBP3 in vivo and in vitro

Zhaohui Chai et al.

BIOLOGICAL RESEARCH (2020)

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Article Clinical Neurology

Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways

Yu Shuang Tian et al.

JOURNAL OF NEUROSURGERY (2019)

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Article Neurosciences

MicroRNA-132 attenuates cerebral injury by protecting blood-brain-barrier in MCAO mice

Xiaokun Zuo et al.

EXPERIMENTAL NEUROLOGY (2019)

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Article Endocrinology & Metabolism

Expression and regulation of miR-449a and AREG in cerebral ischemic injury

Yanhui Yu et al.

METABOLIC BRAIN DISEASE (2019)

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Review Neurosciences

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease

S. Swarbrick et al.

MOLECULAR NEUROBIOLOGY (2019)

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Article Neurosciences

Upregulation of miR-496 decreases cerebral ischemia/reperfusion injury by negatively regulating BCL2L14

Xiaoxi Yao et al.

NEUROSCIENCE LETTERS (2019)

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Review Biochemistry & Molecular Biology

Nanoarchitecture Frameworks for Electrochemical miRNA Detection

Mostafa Kamal Masud et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

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Article Neurosciences

Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1

Rui Wei et al.

EXPERIMENTAL NEUROLOGY (2019)

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Review Neurosciences

The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy

Vennila Ponnusamy et al.

NEUROPHARMACOLOGY (2019)

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Article Biochemical Research Methods

Measurement of microRNA with isothermal DNA amplification on fully automated immunoassay analyzers

Makoto Komori et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2019)

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Article Neurosciences

miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke

Rong Zhang et al.

BRAIN RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis

Xiao-Li Ge et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2019)

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Article Biochemistry & Molecular Biology

Overexpression of miR-224-3p alleviates apoptosis from cerebral ischemia reperfusion injury by targeting FIP200

Yiming Deng et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Review Cell Biology

Roles and regulation of histone methylation in animal development

Ashwini Jambhekar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Pharmacology & Pharmacy

Research advances in the detection of miRNA

Jiawei Ye et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2019)

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Article Clinical Neurology

Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid

Petros Takousis et al.

ALZHEIMERS & DEMENTIA (2019)

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Article Biochemistry & Molecular Biology

MicroRNA-152-3p protects neurons from oxygen-glucose-deprivation/reoxygenation-induced injury through upregulation of Nrf2/ARE antioxidant signaling by targeting PSD-93

Aixiang Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Medicine, Research & Experimental

Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13

Dongxiao Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

Downregulation of microRNA-302b-3p relieves oxygen-glucose deprivation/re-oxygenation induced injury in murine hippocampal neurons through up-regulating Nrf2 signaling by targeting fibroblast growth factor 15/19

Zhenni Zhang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

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Review Biochemistry & Molecular Biology

Role of miRNAs in Alzheimer's Disease and Possible Fields of Application

Serena Silvestro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Clinical Neurology

Curcumin Prevents Brain Damage and Cognitive Dysfunction During Ischemic-reperfusion Through the Regulation of miR-7-5p

Hui Xu et al.

CURRENT NEUROVASCULAR RESEARCH (2019)

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Review Pharmacology & Pharmacy

Therapeutic Oligonucleotides: State of the Art

C. I. Edvard Smith et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

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Article Biochemical Research Methods

The genesis and evolution of bead-based multiplexing

Hilary Graham et al.

METHODS (2019)

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Review Physiology

BLOOD-BRAIN BARRIER: FROM PHYSIOLOGY TO DISEASE AND BACK

Melanie D. Sweeney et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Medicine, Research & Experimental

Optimizing miR-29 measurements in biobanked, heparinized samples

Catherine M. Warnement et al.

LIFE SCIENCES (2019)

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Article Cell Biology

Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke

Changjun Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

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Article Endocrinology & Metabolism

Cortical Neuron-Derived Exosomal MicroRNA-181c-3p Inhibits Neuroinflammation by Downregulating CXCL1 in Astrocytes of a Rat Model with Ischemic Brain Injury

He Song et al.

NEUROIMMUNOMODULATION (2019)

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Review Biochemistry & Molecular Biology

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

Matthew Neal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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Article Neurosciences

Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice

Lei Huang et al.

EXPERIMENTAL NEUROLOGY (2018)

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Article Biochemistry & Molecular Biology

MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes

Yan Wan et al.

FASEB JOURNAL (2018)

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Article Biochemistry & Molecular Biology

MicroRNA-130a regulates cerebral ischemia-induced blood-brain barrier permeability by targeting Homeobox A5

Yong Wang et al.

FASEB JOURNAL (2018)

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Article Cell Biology

MicroRNP-mediated translational activation of nonadenylated mRNAs in a mammalian cell-free system

Motoaki Wakiyama et al.

GENES TO CELLS (2018)

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Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Neurosciences

Role of Blood-Brain Barrier in Alzheimer's Disease

Zhiyou Cai et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Biochemistry & Molecular Biology

Suppression of microRNA-144-3p attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting Brg1/Nrf2/ARE signaling

Yanru Li et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2018)

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Article Biochemistry & Molecular Biology

microRNA-21 Confers Neuroprotection Against Cerebral Ischemia-Reperfusion Injury and Alleviates Blood-Brain Barrier Disruption in Rats via the MAPK Signaling Pathway

Xiaofeng Yao et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

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Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

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Article Multidisciplinary Sciences

Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease

Sandro Da Mesquita et al.

NATURE (2018)

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Article Biochemistry & Molecular Biology

MicroRNA-182-5p attenuates cerebral ischemia-reperfusion injury by targeting Toll-like receptor 4

Ji Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

MiR-539 Targets MMP-9 to Regulate the Permeability of Blood-Brain Barrier in Ischemia/Reperfusion Injury of Brain

Feng Fan et al.

NEUROCHEMICAL RESEARCH (2018)

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Article Neurosciences

Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity

Ying Bai et al.

JOURNAL OF NEUROSCIENCE (2018)

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Review Clinical Neurology

Role of epigenetics in Alzheimer's disease pathogenesis

Andrea Stoccoro et al.

NEURODEGENERATIVE DISEASE MANAGEMENT (2018)

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Article Biochemistry & Molecular Biology

MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury

Qingyi Ma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Biotechnology & Applied Microbiology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rajesha Rupaimoole et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

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Article Neurosciences

LONG NONCODING RNA MALAT1 IS A POTENT AUTOPHAGY INDUCER PROTECTING BRAIN MICROVASCULAR ENDOTHELIAL CELLS AGAINST OXYGEN-GLUCOSE DEPRIVATION/REOXYGENATIONINDUCED INJURY BY SPONGING miR-26b AND UPREGULATING ULK2 EXPRESSION

Zhijun Li et al.

NEUROSCIENCE (2017)

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Article Chemistry, Analytical

Gold Nanoparticle Loaded Split-DNAzyme Probe for Amplified miRNA Detection in Living Cells

Yanan Wu et al.

ANALYTICAL CHEMISTRY (2017)

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Article Medicine, Research & Experimental

Down-regulation of microRNA-142-5p attenuates oxygen-glucose deprivation and reoxygenation-induced neuron injury through up-regulating Nrf2/ARE signaling pathway

Ning Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Review Chemistry, Multidisciplinary

Isothermal Amplification for MicroRNA Detection: From the Test Tube to the Cell

Ruijie Deng et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

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Review Biochemistry & Molecular Biology

RISC assembly: Coordination between small RNAs and Argonaute proteins

Hotaka Kobayashi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)

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Review Cell Biology

Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?

Kotaro Nakanishi

WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)

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Article Chemistry, Analytical

A Comparative Fluorescent Beacon-based Method for Serum microRNA Quantification

Madhu Beta et al.

ANALYTICAL SCIENCES (2015)

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Review Chemistry, Organic

A review: microRNA detection methods

Tian Tian et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

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Review Gastroenterology & Hepatology

Overview of MicroRNA Biology

Ashley M. Mohr et al.

SEMINARS IN LIVER DISEASE (2015)

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Review Cell Biology

Computational Biology in microRNA

Yue Li et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2015)

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Article Neurosciences

Impact of microRNA-134 on neural cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by targeting HSPA12B

Wenying Chi et al.

BRAIN RESEARCH (2014)

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Review Geriatrics & Gerontology

Epigenetically regulated microRNAs in Alzheimer's disease

Daniel L. Van den Hove et al.

NEUROBIOLOGY OF AGING (2014)

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Article Chemistry, Analytical

High Specific and Ultrasensitive Isothermal Detection of MicroRNA by Padlock Probe-Based Exponential Rolling Circle Amplification

Haiyun Liu et al.

ANALYTICAL CHEMISTRY (2013)

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Review Pediatrics

Fetal metabolic programming and epigenetic modifications: a systems biology approach

Silvia Sookoian et al.

PEDIATRIC RESEARCH (2013)

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Article Hematology

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Marek Mraz et al.

BLOOD (2012)

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Article Neurosciences

Blood-Cerebrospinal Fluid Barrier Permeability in Alzheimer's Disease

Sonia Chalbot et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

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Article Biochemistry & Molecular Biology

MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection

Adrian G. Torres et al.

RNA (2011)

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Article Neurosciences

Peroxisome Proliferator-Activated Receptor δ Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury

Ke-Jie Yin et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Neurosciences

miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia

Ke-Jie Yin et al.

NEUROBIOLOGY OF DISEASE (2010)

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Review Biotechnology & Applied Microbiology

Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo

Achim Aigner

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2007)

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Article Biochemistry & Molecular Biology

MicroRNA genes are transcribed by RNA polymerase II

Y Lee et al.

EMBO JOURNAL (2004)

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Article Medicine, Research & Experimental

Enzyme immunoassay of NSE and GFAP as the criterion of dynamic evaluation of the rat blood-brain barrier in perinatal hypoxic ischemic injury of the CNS

VP Chekhonin et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2003)

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